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alpha-2-HS-Glycoprotein (AHSG) (AA 19-367) (Active) protein (His tag)

ABIN2181088 产品详细信息, 供应商: Log in to see
蛋白名称
  • ahs
  • a2hs
  • hsga
  • fetua
  • wu:fb63g02
  • zgc:103687
  • AHSG
  • MGC116429
  • A2HS
  • AHS
  • FETUA
  • HSGA
  • Aa2-066
  • pp63
  • alpha-2-HS-glycoprotein
  • FETUIN protein
  • Cphamn1_1981
  • AHSG
  • ahsg
  • Ahsg
  • FETUIN
产品特性
AA 19-367
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
宿主

32
4
2
1
1
1
1
1
1
1
资源
HEK-293 Cells
12
9
8
4
3
2
2
2
1
蛋白类型
Recombinant
生物活性
Active
标记
This Fetuin A protein is labelled with His tag.
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产品特性 This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.2 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >98 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit calcium phosphate precipitation in 100μL reaction mixture containing 4.8 mM Calcium chloride, 1.6 mM Sodium phosphate, with the rhFetuin A concentration curve of 250, 125, 62.5, 31.3, 15.6, 7.8, 3.9, 1.95, 0.97 and 0.49 μg/mL. The IC50 value is <45 μg/mL.
背景 Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.
分子量 38.2 kDa
NCBI登录号 NP_001613
UniProt P02765
研究领域 Serum/Plasma Proteins
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for alpha-2-HS-Glycoprotein (AHSG) (AA 19-367) (Active) protein (His tag) (ABIN2181088) Human Fetuin A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained...
背景 Lee, Bongcam-Rudloff, Sollner, Jahnen-Dechent, Claesson-Welsh: "Type 3 cystatins; fetuins, kininogen and histidine-rich glycoprotein." in: Frontiers in bioscience (Landmark edition), Vol. 14, pp. 2911-22, 2009 (PubMed).

Heiss, Eckert, Aretz, Richtering, van Dorp, Schäfer, Jahnen-Dechent: "Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles." in: The Journal of biological chemistry, Vol. 283, Issue 21, pp. 14815-25, 2008 (PubMed).

Jahnen-Dechent, Trindl, Godovac-Zimmermann, Müller-Esterl: "Posttranslational processing of human alpha 2-HS glycoprotein (human fetuin). Evidence for the production of a phosphorylated single-chain form by hepatoma cells." in: European journal of biochemistry / FEBS, Vol. 226, Issue 1, pp. 59-69, 1994 (PubMed).