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delta-Like 4 (DLL4) (AA 27-524) (Active) protein (Fc Tag)

ABIN2180973 产品详细信息, 供应商: Log in to see
蛋白名称
  • hdelta2
  • Delta4
  • si:ch211-244p18.5
  • zgc:136596
  • delta-like 4 (Drosophila)
  • DLL4
  • Dll4
  • dll4
产品特性
AA 27-524
7
3
2
2
2
1
1
1
1
1
1
1
1
1
1
宿主

15
8
4
资源
HEK-293 Cells
9
6
4
4
2
1
1
蛋白类型
Recombinant
生物活性
Active
标记
This DLL4 protein is labelled with Fc Tag.
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产品特性 This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 81 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >95 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
背景 Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4). DLL4 contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 plays a role in the Notch signaling pathway. DLL4 activates Notch-1 and Notch-4.
分子量 81 kDa
NCBI登录号 NP_061947
UniProt Q9NR61
研究领域 Chromatin and Nuclear Signaling, Cell Cycle
途径 Notch Signaling
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 50 mM Tris, 100 mM Glycine, pH 7.5
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for delta-Like 4 (DLL4) (AA 27-524) (Active) protein (Fc Tag) (ABIN2180973) Human DLL4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
背景 Brütsch, Liebler, Wüstehube, Bartol, Herberich, Adam, Telzerow, Augustin, Fischer: "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis." in: Circulation research, Vol. 107, Issue 5, pp. 592-601, 2010 (PubMed).

Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).