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Protein Homolog 1 (AA 1-354), (full length) protein (GST tag)

ABIN1047588 产品详细信息, 供应商: Log in to see
蛋白名称
产品特性
AA 1-354, full length
宿主

资源
大肠杆菌(E. Coli)
蛋白类型
Recombinant
标记
GST tag
应用范围
SDS-PAGE (SDS), ELISA
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序列 MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS
产品特性 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
纯度 90 %
背景 Synonyms: Homer-1
分子量 67.7 kD
UniProt Q86YM7
说明

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

限制 仅限研究用
状态 Lyophilized
缓冲液 PBS buffer, 20mM GSH
储存条件 -20 °C
厂商提供的图像
SDS-PAGE (SDS) image for Protein Homolog 1 (AA 1-354), (full length) protein (GST tag) (ABIN1047588) Protein Homolog 1 (AA 1-354), (full length) protein (GST tag)
背景 Xiao, Tu, Petralia, Yuan, Doan, Breder, Ruggiero, Lanahan, Wenthold, Worley: "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins." in: Neuron, Vol. 21, Issue 4, pp. 707-16, 1998 (PubMed).