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Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)

ABIN1046691 产品详细信息, 供应商: Log in to see
蛋白名称
  • Rantes
  • Scya5
  • D17S136E
  • RANTES
  • SCYA5
  • SIS-delta
  • SISd
  • TCP228
  • eoCP
  • MuRantes
  • chemokine (C-C motif) ligand 5
  • LOC100230935
  • CCL5
  • Ccl5
产品特性
AA 24-91, full length
36
2
2
2
1
1
1
1
1
宿主

66
20
12
3
3
2
2
2
1
1
1
1
1
资源
大肠杆菌(E. Coli)
88
9
1
1
1
1
1
1
1
蛋白类型
Recombinant
标记
This CCL5 protein is labelled with His tag.
应用范围
ELISA
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序列 SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
产品特性 Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
纯度 90 %
背景 Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. Ref.3 Ref.8 Ref.10 Ref.11 Ref.12
分子量 11.9 kD
UniProt P13501
途径 Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration
说明

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

限制 仅限研究用
状态 Lyophilized
浓度 0.2-2 mg/mL
缓冲液 Tris-based buffer, 50 % glycerol
注意事项 Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
储存条件 -20 °C
储存方法 Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
厂商提供的图像
SDS-PAGE (SDS) image for Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag) (ABIN1046691) Chemokine (C-C Motif) Ligand 5 (CCL5) (AA 24-91), (full length) protein (His tag)
背景 Capoulade-Métay, Ayouba, Kfutwah, Lole, Pêtres, Dudoit, Deterre, Menu, Barré-Sinoussi, Debré, Theodorou: "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3." in: Immunogenetics, Vol. 58, Issue 7, pp. 533-41, 2006 (PubMed).

Schall, Jongstra, Dyer, Jorgensen, Clayberger, Davis, Krensky: "A human T cell-specific molecule is a member of a new gene family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 3, pp. 1018-25, 1988 (PubMed).