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Adiponectin (ADIPOQ ) (AA 18-247), (full length) protein (His tag)

ABIN1046476 产品详细信息, 供应商: Log in to see
蛋白名称
产品特性
AA 18-247, full length
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1
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宿主
小鼠
76
32
10
9
4
2
1
1
资源
大肠杆菌(E. Coli)
72
12
8
5
4
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4
2
2
2
2
1
1
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1
蛋白类型
Recombinant
标记
His tag
应用范围
Particle-Enhanced Turbidimetric Assay (PETIA), ELISA, Western Blotting (WB)
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序列 EDDVTTTEEL APALVPPPKG TCAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYVYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN
产品特性 Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
纯度 95 %
背景 Synonyms: 30 kDa adipocyte complement-related protein,Adipocyte complement-related 30 kDa protein,ACRP30,Adipocyte, C1q and collagen domain-containing protein,Adipocyte-specific protein AdipoQ
分子量 29 kD
UniProt Q60994
研究领域 Cancer, Atherosclerosis, Metabolism, Hormones
说明

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

限制 仅限研究用
状态 Lyophilized
缓冲液 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole
储存条件 -20 °C
厂商提供的图像
SDS-PAGE (SDS) image for Adiponectin  (ADIPOQ ) (AA 18-247), (full length) protein (His tag) (ABIN1046476) Adiponectin, C1Q and Collagen Domain Containing (ADIPOQ) (AA 18-247), (full length) p...
背景 Wang, Xu, Knight, Xu, Cooper: "Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19521-9, 2002 (PubMed).

Yamauchi, Kamon, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, 2001 (PubMed).