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Huntingtin 蛋白

(Huntingtin (HTT))
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008].
Huntingtin Protein (HTT) (AA 81-190) (GST tag) Huntingtin Protein (HTT) (AA 81-190) (GST tag) Huntingtin Protein (HTT) (AA 81-190) (GST tag) (ABIN1307290)

HTT 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, AA, ELISA

Huntingtin Protein (HTT) (His tag) (ABIN7399553)

HTT 宿主: 大鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 97 % WB, SDS, Imm, PC

Huntingtin Protein (HTT) (His tag) (ABIN7409194)

HTT 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 97 % WB, SDS, Imm, PC

Huntingtin 蛋白 by Origin

Find Huntingtin 蛋白 for a variety of species such as anti-Human Huntingtin, anti-Mouse Huntingtin, anti-Rat Huntingtin. The species listed below are among those available. Click on a link to go to the corresponding products.

Huntingtin 蛋白 by Source

Here you will find Huntingtin 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Huntingtin 蛋白 by 蛋白类型

Here you can find Huntingtin 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

Huntingtin 蛋白 by 应用范围

Find Huntingtin 蛋白 validated for a specific application such as WB, SDS, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Huntingtin 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307290
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399553
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7409194
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399550
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399547
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6123558
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6380205
Quantity 1 mg
Datasheet Datasheet

Aliases for Huntingtin 蛋白

huntingtin (HTT) 蛋白
huntingtin (htt) 蛋白
huntingtin (LOC373520) 蛋白
huntingtin (Htt) 蛋白
AI256365 蛋白
C430023I11Rik 蛋白
CG9995 蛋白
dHtt 蛋白
dhtt 蛋白
Dmel\\CG9995 蛋白
hd 蛋白
HD 蛋白
Hd 蛋白
Hdh 蛋白
Hsap\\HD 蛋白
HTT 蛋白
Htt 蛋白
htt 蛋白
huntington 蛋白
it15 蛋白
IT15 蛋白
SLC6A4 蛋白
ZHD 蛋白
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