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High Fat Diet-induced obese mice exhibit increased OX40 expression in adipose tissues and splenic T cells.
These data support the hypothesis that the Ox40/Ox40L (显示 TNFSF4 ELISA试剂盒) pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus.
OX40 is a death receptor for invariant natural killer T cells and is implicated in pyroptotic cell death.
this study shows that OX40 links a costimulatory receptor to a repressive chromatin remodeling pathway, and that that OX40 stimulation inhibits IL-17 (显示 IL17A ELISA试剂盒) and reduces experimental autoimmune encephalomyelitis
IFNalphaR1 signaling promoted CXCL9 (显示 CXCL9 ELISA试剂盒) and CXCL10 (显示 CXCL10 ELISA试剂盒) synthesis, suggesting that these chemokines might be involved in the LPS (显示 TLR4 ELISA试剂盒) and CD134 costimulation response.
OX40 and ICOS (显示 ICOS ELISA试剂盒) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection
OX40 regulates cardiac remodelling via the modulation of CD4 (显示 CD4 ELISA试剂盒)(+) T-lymphocytes.
bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (显示 CD4 ELISA试剂盒)+ T cells to Th2 cells by ligation of OX40L (显示 TNFSF4 ELISA试剂盒) and OX40 between BMMC-exosomes and CD4 (显示 CD4 ELISA试剂盒)+ T cells and represents a novel mechanism of cell-to-cell communication
Crystal structures and NMR data show that the Roquin (显示 RC3H1 ELISA试剂盒)-1 ROQ domain recognizes hexaloops in the SELEX-derived alternative decay element (ADE) and in an ADE-like variant present in the Ox40 3'-UTR (显示 UTS2R ELISA试剂盒) with identical binding modes.
The OX40-OX40 ligand (显示 TNFSF4 ELISA试剂盒) interaction up-regulates intracellular levels of reactive oxygen species in atherogenesis.
OX40 expression on T cells was positively associated with obesity in humans.
Metabolically active CD4 (显示 CD4 ELISA试剂盒)+ T cells expressing Glut1 (显示 SLC2A1 ELISA试剂盒) and OX40 preferentially harbor HIV during in vitro infection.
OX40 and OX40L (显示 TNFSF4 ELISA试剂盒) formed a functional complex, which may facilitate signal transduction from OX40L (显示 TNFSF4 ELISA试剂盒) to OX40 and contribute to the pathogenesis of Grave's disease.
this study investigated whether CD134 is preferentially expressed on CD4 (显示 CD4 ELISA试剂盒) T cells in drug-induced hypersensitivity syndrome .
blocking of both OX-40L (显示 TNFSF4 ELISA试剂盒) and 4-1BBL (显示 TNFSF9 ELISA试剂盒) reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
Low OX40 expression is associated with colorectal cancer.
OX40 and its ligand are co stimulators for T lymphocytes.
These studies provide the first direct evidence that ligation of tumour necrosis factor (显示 TNF ELISA试剂盒) superfamily members and their cognate receptors is important for the control of viral lytic replication.
Malaria patients and Plasmodium-infected rodents exhibit enhanced expression of the co-stimulatory receptor OX40 on CD4 (显示 CD4 ELISA试剂盒) T cells, which is abrogated following coordinate PD-1 (显示 PDCD1 ELISA试剂盒) co-inhibitory pathways, which are also upregulated during malaria.
Identified two key amino acid residues within CD134 that are required for its interaction with herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells. One of the residues (K79) allows access of the HHV-6B ligand to CD134.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
tumor necrosis factor receptor superfamily, member 4
, tumor necrosis factor receptor superfamily member 4
, OX40 antigen
, OX40L receptor
, tax-transcriptionally activated glycoprotein 1
, ACT35 antigen
, ATC35 antigen
, CD134 antigen
, OX40 cell surface antigen
, OX40 homologue
, TAX transcriptionally-activated glycoprotein 1 receptor
, lymphoid activation antigene ACT35
, tax-transcriptionally activated glycoprotein 1 receptor
, MRC OX40
, Tax-transcriptionally activated glycoprotein 1
, tumor necrosis factor (ligand) superfamily member 4
, tumor necrosis factor superfamily, member 4