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Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4 (显示 RNF4 ELISA试剂盒)) together induce an active conformation of the ubiquitin-conjugating enzyme (显示 Ube2t ELISA试剂盒) Ubc13 (显示 UBE2N ELISA试剂盒)-ubiquitin (Ubc13 (显示 UBE2N ELISA试剂盒)~Ub) thioester.
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (显示 HNRNPD ELISA试剂盒), PHB2 (显示 PHB2 ELISA试剂盒) and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP (显示 KHSRP ELISA试剂盒) resulted in decreased HCMV replication.
Data show RING finger (显示 PCGF1 ELISA试剂盒) (RNF (显示 TRIM31 ELISA试剂盒)) E3 ubiquitin ligase RNF8 (显示 RNF8 ELISA试剂盒) dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13 (显示 UBE2N ELISA试剂盒)/Mms2 with formation of Lys (显示 LYZ ELISA试剂盒)-63 ubiquitin chains, whereas the RNF168 (显示 RNF168 ELISA试剂盒) RING domain is a monomer and does not catalyze Lys (显示 LYZ ELISA试剂盒)-6 ubiquitylation.
the crystal structure of human OTUB1 (显示 OTUB1 ELISA试剂盒) in complex with human UBC13 (显示 UBE2N ELISA试剂盒) and MMS2
entire coding region and splice junctions of RNF8 (显示 RNF8 ELISA试剂盒), UBC13 (显示 UBE2N ELISA试剂盒) and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families
Ubc13 (显示 UBE2N ELISA试剂盒)-Mms2 and Lys63-polyubiquitin (显示 UBB ELISA试剂盒) chains are associated with signaling cellular stress
UBE2v2 signalling through PCNA (显示 PCNA ELISA试剂盒) ubiquitination is not required for immunoglobulin diversification in DT40 cells.
The results in this study allowed identification of important residues of the Ubc13 (显示 UBE2N ELISA试剂盒)-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 (显示 UBE2N ELISA试剂盒) but not other Ubc (显示 RPS27A ELISA试剂盒) proteins.
Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2.
Data demonstrate that divergent activities of Ubc13 (显示 UBE2N ELISA试剂盒) rely on its pairing with either of two Uevs, Uev1A (显示 UBE2V1 ELISA试剂盒) or Mms2.
Ang II (显示 AGT ELISA试剂盒) type 2 receptor signaling attenuates DNA damage and consequent vascular senescence at least in part through methyl methanesulfonate sensitive 2 (MMS2) transactivation.
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
TMEM189-UBE2V1 readthrough transcript
, (clone 18C10) CROC-1B
, ubiquitin-conjugating enzyme E2 variant 1
, ubiquitin-conjugating enzyme E2 variant 2
, ubiquitin-conjugating enzyme E2v2
, Ubiquitin-conjugating enzyme E2 variant 2
, 1 alpha,25-dihydroxyvitamin D3-inducible
, DDVit 1
, MMS2 homolog
, enterocyte differentiation promoting factor
, enterocyte differentiation-associated factor 1
, enterocyte differentiation-associated factor EDAF-1
, enterocyte differentiation-promoting factor 1
, methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
, vitamin D3-inducible protein
, methyl methanesulfonate sensitive 2
, ubc-like protein MMS2
, ubiquitin-conjugating enzyme variant MMS2