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anti-TAR DNA Binding Protein (TARDBP) 抗体产品概述

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anti-TAR DNA Binding Protein 抗体 (TARDBP)
在www.antibodies-online.cn可供236 TAR DNA Binding Protein (TARDBP) 抗体的25不同的供货商。 再加上,我们可以发TAR DNA Binding Protein 试剂盒 (27)TAR DNA Binding Protein 蛋白 (14)和数多这个蛋白质的别的产品。 总共292 TAR DNA Binding Protein产品已列进来了。
别名:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
列出全部抗体 基因 基因ID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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  1. Chicken Polyclonal TARDBP Primary Antibody for ICC, IF - ABIN188986 : Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 12 references for ABIN188986

  2. Human Polyclonal TARDBP Primary Antibody for EIA, IF - ABIN500883 : Buratti, Dörk, Zuccato, Pagani, Romano, Baralle: Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. in The EMBO journal 2001 (PubMed)
    Show all 3 references for ABIN500883

  3. Chicken Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780849 : Buratti, Brindisi, Giombi, Tisminetzky, Ayala, Baralle: TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN2780849

  4. Chicken Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780848 : Estes, Boehringer, Zwick, Tang, Grigsby, Zarnescu: Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. in Human molecular genetics 2011 (PubMed)
    Show all 2 references for ABIN2780848

  5. Human Monoclonal TARDBP Primary Antibody for EIA, IHC (p) - ABIN317572 : Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. in Nature genetics 2008 (PubMed)
    Show all 2 references for ABIN317572

  6. Human Polyclonal TARDBP Primary Antibody for IF, WB - ABIN318898 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

  7. Human Polyclonal TARDBP Primary Antibody for ELISA, WB - ABIN334503 : Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  8. Human Polyclonal TARDBP Primary Antibody for IF, IHC (p) - ABIN657685 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. in The Journal of biological chemistry 2010 (PubMed)

更多抗TAR DNA Binding Protein的相互作用对抗体

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (显示 FUS 抗体) proteins and to highlight their physiological functions--{REVIEW}

  2. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  3. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (显示 IGFALS 抗体)) and frontotemporal lobar degeneration (FTLD).

  4. Possible role of deregulated DNA binding function of TDP-43 in ALS.

  5. These data suggest that Familial Amyotrophic Lateral Sclerosis-linked PFN1 (显示 PFN1 抗体) mutations exacerbate TDP-43-induced neurodegeneration in a gain-of-function manner, possibly by shifting the localization of TDP-43 from nuclei to cytoplasm.

  6. Data suggest that transitions of TDP-43 among soluble, droplet, and aggregate phases are involved in pathological aggregation; TDP-43 prion (显示 PRNP 抗体)-like domain appears to wobble at a cusp of the protein folding energy landscape where any number of factors can tip the balance and trigger the conversion from its native function to its pathological one. [REVIEW]

  7. Secreted PGRN (显示 GRN 抗体) is incorporated into cells via sortilin (显示 SORT1 抗体) or cation-independent mannose 6-phosphate receptor (显示 IGF2R 抗体), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (显示 GRN 抗体) levels led to a cell-type-specific increase of insoluble TDP-43. In the brain tissue of FTLD-TDP patients with PGRN (显示 GRN 抗体) deficiency, CTSD (显示 CTSD 抗体) and phosphorylated TDP-43 accumulated in neurons

  8. Various degrees of TDP-43 cytoplasmic accumulation and nuclear TDP-43 depletion were achieved and the resulting cellular viability was evaluated, leading to a quantitative global analysis on the relative effects of LOF and GOF on the overall cytotoxicity.

  9. results from this study suggest that TDP-43 represents a translational repressor not only for specific mRNAs but for overall translation and that its binding to polyribosomes through RACK1 (显示 GNB2L1 抗体) may promote, under conditions inducingAmyotrophic Lateral Sclerosis pathogenesis, the formation of cytoplasmic inclusions.

  10. using an in vitro cellular model, we demonstrated that Drb1 (显示 RBM45 抗体) co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  2. demonstrated that the levels of HSF1 (显示 HSF1 抗体) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  3. The present study identified USP7 (显示 USP7 抗体) and TDP-43 as the regulators of CRY1 (显示 CRY1 抗体) and CRY2 (显示 CRY2 抗体), underscoring the significance of the stability control process of CRY (显示 CRY2 抗体) proteins for period determination in the mammalian circadian clockwork.

  4. TDP-43 functions within a network of hnRNP (显示 HNRNPH2 抗体) proteins to inhibit the production of a truncated human SORT1 (显示 SORT1 抗体) receptor.

  5. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  6. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  7. UBQLN2 (显示 UBQLN2 抗体) dysregulation in neurons can drive NF-kappaB (显示 NFKB1 抗体) activation and cytosolic TDP-43 aggregation.

  8. These findings demonstrate a role for PABPN1 (显示 PABPN1 抗体) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  9. identifies DDX58 (显示 DDX58 抗体) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

  10. Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (显示 CNBP 抗体) tardbp and RNA binding protein fus (显示 FUS 抗体).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (显示 FUS 抗体) act in a pathogenic pathway that is independent of SOD1 (显示 SOD1 抗体).

TAR DNA Binding Protein (TARDBP) 抗原简介

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) 抗体
  • Tardbp protein (tardbp) 抗体
  • TAR DNA binding protein (tardbp) 抗体
  • TAR DNA binding protein (Tardbp) 抗体
  • TAR DNA-binding protein 43-like (LOC100621383) 抗体
  • 1190002A23Rik 抗体
  • ALS10 抗体
  • C85084 抗体
  • DKFZp459I2127 抗体
  • tardbp 抗体
  • TDP-43 抗体
  • Tdp43 抗体
  • wu:fb77f02 抗体
  • wu:fc52g10 抗体

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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