anti-TAR DNA Binding Protein (TARDBP) 抗体产品概述

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anti-TAR DNA Binding Protein 抗体 (TARDBP)
在www.antibodies-online.cn可供241 TAR DNA Binding Protein (TARDBP) 抗体的26不同的供货商。 再加上,我们可以发TAR DNA Binding Protein 试剂盒 (32)TAR DNA Binding Protein 蛋白 (14)和数多这个蛋白质的别的产品。 总共302 TAR DNA Binding Protein产品已列进来了。
别名:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
列出全部抗体 基因 基因ID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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  1. Chicken Polyclonal TARDBP Primary Antibody for ICC, IF - ABIN188986 : Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 12 references for 188986

  2. Human Monoclonal TARDBP Primary Antibody for EIA, IHC (p) - ABIN317572 : Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. in Nature genetics 2008 (PubMed)
    Show all 2 references for 317572

  3. Cow (Bovine) Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780849 : Buratti, Brindisi, Giombi, Tisminetzky, Ayala, Baralle: TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for 2780849

  4. Cow (Bovine) Polyclonal TARDBP Primary Antibody for IHC, WB - ABIN2780848 : Estes, Boehringer, Zwick, Tang, Grigsby, Zarnescu: Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. in Human molecular genetics 2011 (PubMed)
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  5. Human Polyclonal TARDBP Primary Antibody for ELISA, WB - ABIN334503 : Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  6. Human Polyclonal TARDBP Primary Antibody for IF, WB - ABIN318898 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

  7. Human Polyclonal TARDBP Primary Antibody for IF, IHC (p) - ABIN657685 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. in The Journal of biological chemistry 2010 (PubMed)

更多抗TAR DNA Binding Protein的相互作用对抗体

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. we demonstrated cytoplasmic TDP-43 aggregate formation in neuronal and glial cells following adenoviral transduction of WT and CTF (显示 NFIA 抗体) TDP-43 under MG-132 treatment. These TDP-43 aggregates were phosphorylated and ubiquitinated and consisted of electron-dense granules.

  2. emphasize the importance of distinguishing cerebral age-related TDP-43 with sclerosis from late-onset frontotemporal lobar degeneration with TDP-43 pathology and from advanced Alzheimer disease with TDP-43 pathology

  3. Mutant and wild type human TDP-43 replacing the endogenous Drosophila gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.

  4. The study establishes a functional/physical partnership between FMRP (显示 FMR1 抗体) and TDP-43 that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.

  5. By silencing TDP-43, authors saw significant inhibition of cell proliferation and metastasis in A375 and WM451 cells. TDP-43 knockdown could suppress glucose transporter type-4 (GLUT4 (显示 SLC2A4 抗体)) expression and reduce glucose uptake.

  6. The present study, based on 15 cases staged for pTDP-43 pathology, reports the finding that pathologically altered TDP-43 in Betz cells reacts differently than that in bulbar or spinal alpha-motoneurons. The major differences between the two types of histological profiles are discussed within the context of their possible consequences and implications for the potential further progression or spread of the pTDP-43 lesions.

  7. This study have shown that TDP-43-positive cytoplasmic inclusions were frequently found in the amygdala of pathologically and genetically confirmed cases of Frontotemporal Lobar Degeneration and Motor Neuron Disease.

  8. Results indicated that a range of disease specific TDP-43 variants are generated in amyotrophic lateral sclerosis patients with different variants being generated in sporadic and familial cases.

  9. heterogeneous structural reorganization and decreased stability of the truncated RRM2 (显示 RRM2 抗体) domain

  10. These results suggest that Perry syndrome may be distinctive type of TDP-43 proteinopathy.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. The findings of this study support a role for nuclear depletion of TDP-43 in the pathogenesis of AD and provide strong rationale for developing novel therapeutics to alleviate the depletion of TDP-43 and functional antemortem biomarkers associated with its nuclear loss.

  2. These results suggested that nuclear localization signal -tagged TDP25 (a carboxyl-terminal fragment of TDP-43) can change its structure to use ordered oligomeric but nontoxic state. Moreover, the structure of ordered oligomers as well as nuclear sequestration may be important in mediating cytotoxicity in ALS pathology.

  3. Mutatgion M337V in TDP-43 impaired the Nrf2 (显示 NFE2L2 抗体)/ARE pathway by reducing the expression of MafK and JDP2 (显示 JDP2 抗体) proteins.

  4. The suppression of TDP-43 mitochondrial localization abolishes WT and mutant TDP-43-induced mitochondrial dysfunction and neuronal loss, and improves phenotypes of transgenic mutant TDP-43 mice.

  5. we found a significant overlap in genes that undergo both RBM17 (显示 RBM17 抗体)- and TDP-43-dependent cryptic splicing repression, many of which are associated with survival. We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival

  6. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  7. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  8. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  9. demonstrated that the levels of HSF1 (显示 HSF1 抗体) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  10. The present study identified USP7 (显示 USP7 抗体) and TDP-43 as the regulators of CRY1 (显示 CRY1 抗体) and CRY2 (显示 CRY2 抗体), underscoring the significance of the stability control process of CRY (显示 CRY2 抗体) proteins for period determination in the mammalian circadian clockwork.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (显示 CNBP 抗体) tardbp and RNA binding protein fus (显示 FUS 抗体).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (显示 FUS 抗体) act in a pathogenic pathway that is independent of SOD1 (显示 SOD1 抗体).

TAR DNA Binding Protein (TARDBP) 抗原简介

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) 抗体
  • Tardbp protein (tardbp) 抗体
  • TAR DNA binding protein (tardbp) 抗体
  • TAR DNA binding protein (Tardbp) 抗体
  • TAR DNA-binding protein 43-like (LOC100621383) 抗体
  • 1190002A23Rik 抗体
  • ALS10 抗体
  • C85084 抗体
  • DKFZp459I2127 抗体
  • tardbp 抗体
  • TDP-43 抗体
  • Tdp43 抗体
  • wu:fb77f02 抗体
  • wu:fc52g10 抗体

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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