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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN414447
Lu, Jiang, Chen, Xu, Hu, Zhao, Gao, Guo: Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. in PLoS ONE 2013
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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN416136
Chen, Pan, Liu, Chen, Liu, Yeh, Tsai, Young, Zhang, Chao: The effects and underlying mechanisms of S-allyl l-cysteine treatment of the retina after ischemia/reperfusion. in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2012
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Rat (Rattus) HIF1A ELISA Kit for Sandwich ELISA - ABIN368077
Rodríguez-Gómez, Banegas, Wangensteen, Quesada, Jiménez, Gómez-Morales, OValle, Duarte, Vargas: Influence of thyroid state on cardiac and renal capillary density and glomerular morphology in rats. in The Journal of endocrinology 2013
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Human HIF1A ELISA Kit for Sandwich ELISA - ABIN366532
Jiang, Tang, Guo, Jiao: The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes. in Annals of clinical and laboratory science 2013
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Mouse (Murine) HIF1A ELISA Kit for Sandwich ELISA - ABIN424082
Du, Lin, Wang, Zhang, Wu, Lu, Ji, Yu: Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1? in tumor and normal cells. in Cancer chemotherapy and pharmacology 2011
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Pig (Porcine) HIF1A ELISA Kit for Sandwich ELISA - ABIN368480
Gyöngyösi, Hemetsberger, Posa, Charwat, Pavo, Petnehazy, Petrasi, Pavo, Hemetsberger, Benedek, Benedek, Benedek, Kovacs, Kaun, Maurer: Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. in Journal of cardiovascular translational research 2010
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1081535
Sun, Wang, Liu, Lin, Hua: Resveratrol abrogates the effects of hypoxia on cell proliferation, invasion and EMT in osteosarcoma cells through downregulation of the HIF-1? protein. in Molecular medicine reports 2014
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN2344926
Ohyama, Toyomura, Tachibana, Isonishi, Takahashi, Ishikawa: Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary. in Human cell 2016
Human HIF1A ELISA Kit for Sandwich ELISA - ABIN1115458
Chandravanshi, Bhonde: Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia. in European journal of pharmacology 2016
Data indicate that the HIF-1alpha/VEGF-A (显示 VEGFA ELISA试剂盒) axis is an essential aspect of tumor immunity.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
findings suggest that hypoxia, through HIF1A, contributes to the development and progression of pulmonary fibrosis through its regulation of ADORA2B (显示 ADORA2B ELISA试剂盒) expression on alternatively activated macrophages, cell differentiation, and production of profibrotic mediators
Death receptor5 pathway and mitochondrial pathway, which are likely mediated by HIF-1alpha, contribute to hypoxia-induced spermatocyte apoptosis.
Mechanical low shear stress activates HIF1alpha at atheroprone regions of arteries via nuclear factor-kappaB and Cezanne. HIF1alpha promotes atherosclerosis initiation at these sites by inducing excessive endothelial cell proliferation and inflammation via the induction of glycolysis enzymes.
CRP (显示 CRP ELISA试剂盒) can upregulate vascular endothelial growth factor-A (VEGF-A (显示 VEGFA ELISA试剂盒)) expression by activating hypoxia inducible factor-1alpha (HIF-1alpha) in ADSCs.
induction of HIF-1alpha mediated transcriptional up-regulation of pro-apoptotic/inflammatory signaling contributes to astrocyte cell death during thiamine deficiency.
Smad3 (显示 SMAD3 ELISA试剂盒) binding to the -335 hypoxia-responsive element of the COL1A2 (显示 COL1A2 ELISA试剂盒) promoter required HIF-1alpha both in vitro and in kidney lysate from the disease model, suggesting formation of an HIF-1alpha-Smad3 (显示 SMAD3 ELISA试剂盒) transcriptional complex. Thus, HIF-1alpha-Smad3 (显示 SMAD3 ELISA试剂盒) has a novel interaction in glomerulosclerosis.
These results suggest that cyclosporine A (CsA (显示 HSPA9 ELISA试剂盒)) exhibits antifibrotic effects by degrading HIF-1alpha and that the CsA (显示 HSPA9 ELISA试剂盒)-HIF-1alpha axis provides new insights into therapeutic options for the treatment of pulmonary fibrosis.
HIF-1alpha protein levels in the ipsilateral hemisphere were higher in the WT mice than Par-1 (显示 MARK2 ELISA试剂盒) KO mice after glioma cell implantation.
Results show that HIF-1a expression is positively regulated by LINC00152 through its binding to miR (显示 MLXIP ELISA试剂盒)-138.
These results indicate that the immunohistochemistry analysis of the protein expression of PDK1 (显示 PDK1 ELISA试剂盒), PHD3 (显示 EGLN3 ELISA试剂盒), and HIF-1alpha defines the hypoxic status of Neuroblastoma (显示 ARHGEF16 ELISA试剂盒) tumors.
This phosphorylation increases its ability to degrade HIF1alpha.
MiR (显示 MLXIP ELISA试剂盒)-31-5p plays an important role in HS formation by inhibiting FIH (显示 CASR ELISA试剂盒) and regulating the HIF-1alpha pathway.
ASK1 (显示 MAP3K5 ELISA试剂盒) phosphorylated and stabilized TLX (显示 CD46 ELISA试剂盒), which led induction of HIF-1alpha, and its downstream VEGF-A (显示 VEGFA ELISA试剂盒) in an Akt (显示 AKT1 ELISA试剂盒) dependent manner.
The BAFF (显示 TNFSF13B ELISA试剂盒) promoter increased in response to TNF-alpha (显示 TNF ELISA试剂盒) treatment or overexpression of HIF-1alpha. However, TNF-alpha (显示 TNF ELISA试剂盒)-induced BAFF (显示 TNFSF13B ELISA试剂盒) expression and promoter activity decreased after treatment with the ERK (显示 EPHB2 ELISA试剂盒) inhibitor PD98059.
This study demonstrated that HIF-1alpha is a key regulator of glucose metabolism in skeletal muscle by directly controlling the transcription of RAB20 and TXNIP (显示 TXNIP ELISA试剂盒).
we report that genetic removal of CSL in breast tumor cells caused accelerated growth of xenografted tumors. Loss of CSL unleashed a hypoxic response during normoxic conditions, manifested by stabilization of the HIF1alpha protein and acquisition of a polyploid giant-cell, cancer stem cell-like, phenotype.
NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha/HIF2alpha (显示 EPAS1 ELISA试剂盒), VEGF (显示 VEGFA ELISA试剂盒)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (显示 BAX ELISA试剂盒) and Bcl2 (显示 BCL2 ELISA试剂盒).
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (显示 HSP70 ELISA试剂盒)) was noted
Induction of ischemic osteonecrosis results in IL-6 (显示 IL6 ELISA试剂盒) production in the articular cartilage through an HIF-1-dependent pathway.
Upregulation of VEGF (显示 VEGFA ELISA试剂盒) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (显示 SOX9 ELISA试剂盒) expression and enhances Sox9 (显示 SOX9 ELISA试剂盒)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (显示 EPAS1 ELISA试剂盒) was observed during endochondral ossification, whereas only HIF-2alpha (显示 EPAS1 ELISA试剂盒) was present at sites of intramembranous ossification
Downregulation of miR (显示 MYLIP ELISA试剂盒)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (显示 SIRT1 ELISA试剂盒) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow
Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (显示 HSP70 ELISA试剂盒) overexpression increased the expression levels of ECM (显示 MMRN1 ELISA试剂盒) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (显示 HSP70 ELISA试剂盒) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
HIF-1-mediated activation of 5-HT (显示 DDC ELISA试剂盒) signalling promotes axon regeneration by activating both the RhoA (显示 RHOA ELISA试剂盒) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (显示 FMO2 ELISA试剂盒)).
AMPK (显示 PRKAA1 ELISA试剂盒) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (显示 ROS1 ELISA试剂盒)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (显示 PRKAA1 ELISA试剂盒) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
Data show that that reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)) are increased in respiration mutants and that mild increases in ROS (显示 ROS1 ELISA试剂盒) can stimulate HIF-1 to activate gene expression and promote longevity.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit