anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) 抗体产品概述

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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 抗体 (HIF1A)
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别名:
AA959795, bHLHe78, hif-1a, HIF-1alpha, HIF1, HIF1-alpha, hif1a, HIF1alpha, MOP1, PASD8
列出全部抗体 基因 基因ID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
大鼠 HIF1A HIF1A 29560 O35800

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引用最多的anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 抗体

  1. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ChIP, ELISA - ABIN151032 : Bernhardt, Câmpean, Kany, Jürgensen, Weidemann, Warnecke, Arend, Klaus, Günzler, Amann, Willam, Wiesener, Eckardt: Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. in Journal of the American Society of Nephrology : JASN 2006 (PubMed)
    Show all 667 references for 151032

  2. Bird (Avian) Monoclonal HIF1A Primary Antibody for ChIP, GS - ABIN151053 : An, Maeng, Kang, Lee, Kim, Paik, Lee: Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. in The Journal of biological chemistry 2006 (PubMed)
    Show all 129 references for 151053

  3. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN151061 : Abbate, Santini, Biondi-Zoccai, Scarpa, Vasaturo, Liuzzo, Bussani, Silvestri, Baldi, Crea, Biasucci, Baldi: Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? in Heart (British Cardiac Society) 2004 (PubMed)
    Show all 60 references for 151061

  4. Human Polyclonal HIF1A Primary Antibody for IF (cc), IF (p) - ABIN672546 : Shou, Lin, Liang, Li, Chen: Expression and prognosis of FOXO3a and HIF-1? in nasopharyngeal carcinoma. in Journal of cancer research and clinical oncology 2012 (PubMed)
    Show all 9 references for 672546

  5. Human Monoclonal HIF1A Primary Antibody for IHC (p), IP - ABIN151762 : Gillespie, Whang, Ragel, Flynn, Kelly, Jensen: Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)
    Show all 6 references for 151762

  6. Human Polyclonal HIF1A Primary Antibody for IF, IHC (p) - ABIN392176 : Favaro, Nardo, Persano, Masiero, Moserle, Zamarchi, Rossi, Esposito, Plebani, Sattler, Mann, Mueller-Klieser, Ciminale, Amadori, Indraccolo: Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. in The American journal of pathology 2008 (PubMed)
    Show all 3 references for 392176

  7. Human Polyclonal HIF1A Primary Antibody for FACS, IF - ABIN652389 : Lee, Lee, Kim, Kim, Jung, Seo, Park, Choi, Yim, Lee, Park, Yoo, Kim, Lee, Kim, Ryeom, Kim, Oh: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. in Journal of the National Cancer Institute 2010 (PubMed)
    Show all 2 references for 652389

  8. Human Polyclonal HIF1A Primary Antibody for EIA, IHC (p) - ABIN360059 : Alexandru, Graumann, Smith, Kolawa, Fang, Deshaies: UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. in Cell 2008 (PubMed)
    Show all 2 references for 360059

  9. Cow (Bovine) Polyclonal HIF1A Primary Antibody for WB - ABIN2780373 : Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008 (PubMed)

更多抗Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor)的相互作用对抗体

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. We conclude that HIF-1 is not a major regulator of Vegfa (显示 VEGFA 抗体) expression during wound healing; rather, it serves to maintain basal levels of expression of Vegfa (显示 VEGFA 抗体) and its target genes in intact skin, which are required for optimal granulation tissue formation in response to wounding.

  2. hypoxic IL-22 (显示 IL22 抗体) upregulation is dependent on HIF-1alpha

  3. Lactic Acid Suppresses IL-33 (显示 IL33 抗体)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (显示 MLXIP 抗体)-155 Suppression

  4. Lactic Acid Suppresses IL-33 (显示 IL33 抗体)-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1alpha-Dependent miR (显示 MLXIP 抗体)-155 Suppression

  5. HIF-1alpha and GDF15 (显示 GDF15 抗体) expression are inversely related under normoxia and hyperoxia.

  6. HIF-1alpha induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (显示 MLXIP 抗体)-21 via inhibiting a novel target gene TSP-1 (显示 GZMA 抗体). Both of them may contribute to the protective effect of HIF-1alpha on renal I/R injury.

  7. studies in humans and mice reveal that Akt2 (显示 AKT2 抗体) controls hepatic tumorigenesis through crosstalk between HNF1alpha (显示 HNF1A 抗体) and PPARgamma (显示 PPARG 抗体).

  8. We conclude that HIF1alpha is activated in alveolar type II cells after lung injury and promotes proliferation and spreading during repair.

  9. HIF1alpha-dependent glycolytic activity is responsible for mTOR (显示 FRAP1 抗体)-deficient, increased myeloid-derived suppressive cell functional changes in IMH inflammation.

  10. Activation of HIF1A by prolonged in vivo hyperinsulinemia potentiates cancerous progression in estrogen receptor (显示 ESR1 抗体)-positive breast cancer cells.

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. HIF1a is elevated in HUVECs exposed to heme and treatment with hydroxyurea and simvastatin reduced the production.

  2. Results indicated that hypoxia-induced Mxd1 (显示 MXD1 抗体) expression was mediated by HIF-1alpha in osteosarcoma cells.

  3. HIF-1alpha was destabilised in the presence of bile acids in all tested, human tumor cell lines.

  4. these data suggest that HIF-1alpha expression represents a candidate prognostic biomarker for clinical application in high-grade leiomyosarcoma and undifferentiated pleomorphic sarcoma

  5. HIF-1alpha and GDF15 (显示 GDF15 抗体) expression are inversely related under normoxia and hyperoxia.

  6. Our findings suggest that GATA3 (显示 GATA3 抗体) stabilizes HIF-1alpha to enhance cancer invasiveness under hypoxia

  7. Aldolase (显示 ALD 抗体) A promotes lung cancer metastasis via PHD (显示 PDC 抗体)-mediated stabilization of HIF-1alpha and the subsequent activation of MMP9 (显示 MMP9 抗体).

  8. Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha) is phylogenetically conserved among most metazoans, whereas HIF-2alpha (显示 EPAS1 抗体) protein appeared later.

  9. present study identifies the crucial regulation of hsa_circ_0010729 on vascular endothelial cell proliferation and apoptosis via targeting miR (显示 MLXIP 抗体)-186/HIF-1alpha axis

  10. TrpC5 (显示 TRPC5 抗体) induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer.

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (显示 HSP70 抗体)) was noted

  2. Induction of ischemic osteonecrosis results in IL-6 (显示 IL6 抗体) production in the articular cartilage through an HIF-1-dependent pathway.

  3. Upregulation of VEGF (显示 VEGFA 抗体) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  4. HIF-1alpha activates Sox9 (显示 SOX9 抗体) expression and enhances Sox9 (显示 SOX9 抗体)-mediated transcriptional activity.

  5. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  6. immunostaining for HIF-1alpha and HIF-2alpha (显示 EPAS1 抗体) was observed during endochondral ossification, whereas only HIF-2alpha (显示 EPAS1 抗体) was present at sites of intramembranous ossification

  7. Downregulation of miR (显示 MYLIP 抗体)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (显示 SIRT1 抗体) and recapitulates hypoxia preconditioning in cardiac myocytes.

  8. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow

  2. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  3. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  4. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  5. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (显示 HSP70 抗体) overexpression increased the expression levels of ECM (显示 MMRN1 抗体) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (显示 HSP70 抗体) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.

  2. HIF-1-mediated activation of 5-HT (显示 DDC 抗体) signalling promotes axon regeneration by activating both the RhoA (显示 RHOA 抗体) and cAMP pathways.

  3. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (显示 FMO2 抗体)).

  4. AMPK (显示 PRKAA1 抗体) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (显示 ROS1 抗体)

  5. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (显示 PRKAA1 抗体) compromised C. elegans dauer larvae.

  7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  8. Data indicate that genes sqrd-1, ethe-1 (显示 ETHE1 抗体), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (显示 SQRDL 抗体) and hydrogen cyanide.

  9. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  10. Data show that that reactive oxygen species (ROS (显示 ROS1 抗体)) are increased in respiration mutants and that mild increases in ROS (显示 ROS1 抗体) can stimulate HIF-1 to activate gene expression and promote longevity.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) 抗原简介

Antigen Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Alternative names and synonyms associated with Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

  • hypoxia inducible factor 1 alpha (hif-1a) 抗体
  • hypoxia inducible factor 1, alpha subunit (Hif1a) 抗体
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A) 抗体
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) 抗体
  • hypoxia-inducible factor 1 alpha (hif-1a) 抗体
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) 抗体
  • Protein HIF-1 (hif-1) 抗体
  • AA959795 抗体
  • bHLHe78 抗体
  • hif-1a 抗体
  • HIF-1alpha 抗体
  • HIF1 抗体
  • HIF1-alpha 抗体
  • hif1a 抗体
  • HIF1alpha 抗体
  • MOP1 抗体
  • PASD8 抗体

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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