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FcRn 抗体

(IgG receptor FcRn (FcRn))

The neonatal Fc receptor (FnRn) owes its name to being the receptor that transports maternal IgG from mother to lactating neonatal offspring and for being identified first in the intestine of neonatal rats as the receptor responsible for the transport of IgG from the lumen to the circulation. However, FcRn functions are far more universal, and it is virtually ubiquitously expressed.

FcRn is considered a non-classical Fc receptor for IgG (FcγR). It is structurally related to major histocompatibility class I (MHC-I) family and it associates with beta-2-microglobulin (β2m). On the other hand, it does not present antigenic peptides to T cells and. It has also a second interaction partner, albumin, that is not involved in the body’s immune response. FcRn prevents intracellular degradation of IgG and albumin and extends their half-life considerable, making them the two most abundant serum proteins.

Because of its interaction with IgG and albumin, FcRn has become a high-interest therapeutic target. For one, it can be exploited to extend the half-life of therapeutic antibodies and IgG- or albumin-fused proteins. Mutations of amino acids influencing the pH dependency of IgG and albumin binding can be mutated to achieve the desired effect. Binding of IgG to FcRn also offers the possibility to enhance their clearance. Autoantibodies that recognized self-antigens are the cause of certain autoimmune diseases. By engineering competing antibodies that bind tighter to FcRn and effectively block the receptor increase clearance of the disease-causing antibodies. Lastly, the FcRn enhances the transport of therapeutic IgG fc or albumin fusion-protein across mucosal membranes, thus facilitating distribution and improving their absorption.

Anti-FcRn antibodies are essential tools to elucidate the biological function of FcRn under normal circumstances and in pathologies such as autoimmune disease and cancer. They enable FcRn imaging in tissue using IHC or IF and quantitation through FACS. As blocking reagents they are useful to identify epitopes on FcRn targeted by antibody-based drugs or albumin-conjugated therapeutics. They can also use autoantibody recycling and influence the half-life of therapeutic antibodies.

Albumin and IgG binding to FcRn-β2m - antibodies-online.com

Binding of albumin (orange) and IgG (purple) to the FcRn-β2m heterodimer based on PDB structure 4N0U. Under mildly acidic conditions, glutamate and aspartate residues in the CH2 and CH3 domains of one IgG Fc fragment form hydrogen bonds with histidine residues in the α2 domains of two FcRn molecules. Albumin binds via its DIII and DI domains at a 1:1 stoichiometry to FcRn in a different region. Antibody blocking assays suggest that anti-FcRn antibody clones ADM31 (ABIN1774762) and ADM32 bind to the FcRn-β2m heterodimer within the albumin binding region whereas clone DVN24 (ABIN1774763) and DVN21 block IgG binding.

FcRn 抗体 FcRn 抗体 FcRn 抗体 (ABIN1774762)

FcRn 适用: 人 ELISA, IF, FACS, cELISA, Func 宿主: 小鼠 Monoclonal ADM31 unconjugated

FcRn 抗体  (AA 24-297) FcRn 抗体  (AA 24-297) FcRn 抗体 (AA 24-297) (ABIN7156043)

FcRn 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

FcRn 抗体  (AA 24-365) FcRn 抗体  (AA 24-365) FcRn 抗体 (AA 24-365) (ABIN7441535)

FcRn 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

FcRn 抗体 by 适用

Find FcRn 抗体 for a variety of species such as anti-Human FcRn, anti-Mouse FcRn, anti-Cynomolgus FcRn. The species listed below are among those available. Click on a link to go to the corresponding products.

FcRn 抗体 by 应用范围

Find FcRn 抗体 validated for a specific application such as WB, ELISA, IHC, FACS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

FcRn 抗体 by 抗体来源

Find FcRn 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

FcRn 抗体 by 抗原表位

Find FcRn 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

FcRn 抗体 by 克隆形成能力

Find available monoclonal or polyclonal FcRn 抗体. Click on a link to go to the corresponding products.

FcRn 抗体 by 克隆

Find FcRn 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

FcRn 抗体 by 标记

Find FcRn 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular FcRn 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, FACS, cELISA, Func
Validations
  • (15)
  • (6)
Cat. No. ABIN1774762
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (7)
Cat. No. ABIN7156043
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7441535
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ISt, StM
Validations
  • (4)
Cat. No. ABIN6939380
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (4)
Cat. No. ABIN7193244
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS, Neut
Validations
  • (4)
Cat. No. ABIN7193245
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6140552
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Sheep
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN2782616
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IF, FACS, cELISA
Validations
  • (2)
  • (2)
Cat. No. ABIN1774763
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN321108
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p)
Validations
  • (2)
Cat. No. ABIN3044522
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN3044521
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN1537146
Quantity 400 μL
Datasheet Datasheet
Reactivity Cynomolgus
Application ELISA
Validations
Cat. No. ABIN7176834
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Application
Validations
Cat. No. ABIN7176833
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our FcRn 抗体

Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." in: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

Gjølberg, Frick, Mester, Foss, Grevys, Høydahl, Jørstad, Schlothauer, Sandlie, Moe, Andersen: "Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life." in: Communications biology, Vol. 5, Issue 1, pp. 832, (2022) (PubMed).

Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." in: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." in: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

Bern, Nilsen, Ferrarese, Sand, Gjølberg, Lode, Davidson, Camire, Bækkevold, Foss, Grevys, Dalhus, Wilson, Høydahl, Christianson, Roopenian, Schlothauer, Michaelsen, Moe, Lombardi, Pinotti, Sandlie et al.: "An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. ..." in: Science translational medicine, Vol. 12, Issue 565, (2021) (PubMed).

Casulleras, Flores-Costa, Duran-Güell, Alcaraz-Quiles, Sanz, Titos, López-Vicario, Fernández, Horrillo, Costa, de la Grange, Moreau, Arroyo, Clària: "Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis." in: Science translational medicine, Vol. 12, Issue 566, (2021) (PubMed).

Catlin, Mitchell, Potchoiba, OHara, Wang, Zhang, Weinbauer, Bowman: "Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey." in: Birth defects research, Vol. 112, Issue 1, pp. 105-117, (2020) (PubMed).

Blumberg, Humphries, Jones, Pearce, Holgate, Hearn, Cheung, Mahmood, Del Tito, Graydon, Stolz, Bitonti, Purohit, de Graaf, Kacena, Andersen, Christianson, Roopenian, Hubbard, Gandhi, Lasseter, Pyzik et al.: "Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. ..." in: Science advances, Vol. 5, Issue 12, pp. eaax9586, (2020) (PubMed).

Bequignon, Dhommée, Angely, Thomas, Bottier, Escudier, Isabey, Coste, Louis, Papon, Gouilleux-Gruart: "FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?" in: International journal of molecular sciences, Vol. 20, Issue 6, (2019) (PubMed).

Chung, Nguyen, Lin, Lafrance-Vanasse, Scales, Lin, Deng, Williams, Sperinde, Li, Zheng, Sukumaran, Tesar, Ernst, Fischer, Lazar, Prabhu, Song: "An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans." in: mAbs, Vol. 11, Issue 5, pp. 942-955, (2019) (PubMed).

Aliases for FcRn 抗体

Fc fragment of IgG receptor and transporter (FCGRT) 抗体
Fc fragment of IgG receptor and transporter (Fcgrt) 抗体
Fc receptor, IgG, alpha chain transporter (Fcgrt) 抗体
alpha-chain 抗体
FCRN 抗体
FcRn 抗体
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