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Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.
Results indicate that TRN1 positively regulates miRNA activity by promoting the association of miRNAs with AGO1 (显示 EIF2C1 ELISA试剂盒), and they reveal opposing roles of two importin beta (显示 KPNB1 ELISA试剂盒) family proteins in miRNA loading.
Results show that tranportin 1 (AtTRN1) recognizes a broad spectrum of proteins having diverse functions, which will potentially be the cargoes of AtTRN1.
These results suggest that Aqp0a is the primary water channel (显示 AQP4 ELISA试剂盒) of the lens and that Aqp0b, though possibly a secondary water channel (显示 AQP4 ELISA试剂盒), has an unidentified function in the lens.
the TNPO1-Rab8 (显示 RAB8A ELISA试剂盒)-ciliary targeting signals complex mediates selective entry into and retention of cargos within cilia.
SIN1 (显示 MAPKAP1 ELISA试剂盒) plays an important role in non-small cell lung cancer; SIN1 (显示 MAPKAP1 ELISA试剂盒) is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1 (显示 MAPKAP1 ELISA试剂盒), a known element of the mammalian target of rapamycin (显示 FRAP1 ELISA试剂盒) complex 2 (mTORC2 (显示 CRTC2 ELISA试剂盒)), is required for Interferon-gamma (显示 IFNG ELISA试剂盒)-induced phosphorylation and activation of AKT (显示 AKT1 ELISA试剂盒) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Together, these results indicate that transportin-1 mediates YB-1 (显示 YBX1 ELISA试剂盒) nuclear translocation.
findings suggest that a new player, i.e., O-GlcNAcylation, regulates hnRNP A1 translocation and interaction with Trn1, possibly affecting its function
Intracellular localization of mTORC2 (显示 CRTC2 ELISA试剂盒) component, mSin1, contributes to regulation of Akt (显示 AKT1 ELISA试剂盒) phosphorylation.
Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
Results show that Karyopherin-b2 binds to the N-terminal tail of histone H3 (显示 HIST3H3 ELISA试剂盒) with high affinity even though H3 lacks a recognizable proline-tyrosine nuclear localization signal (PY-NLS (显示 ALDH1A2 ELISA试剂盒)).
FGF2 (显示 FGF2 ELISA试剂盒) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase (显示 RAN ELISA试剂盒) in human glioblastoma cells
Akt (显示 AKT1 ELISA试剂盒) phosphorylates SIN1 (显示 MAPKAP1 ELISA试剂盒) at T86, enhancing mTORC2 (显示 CRTC2 ELISA试剂盒) kinase activity, which leads to phosphorylation of Akt (显示 AKT1 ELISA试剂盒) S473 by mTORC2 (显示 CRTC2 ELISA试剂盒), thereby catalyzing full activation of Akt (显示 AKT1 ELISA试剂盒).
Co-immunoprecipitation and affinity-binding studies revealed that Rab23 (显示 RAB23 ELISA试剂盒) exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 (显示 RAB23 ELISA试剂盒) for its ciliary transport
Association with Tnpo1 is necessary for Oxtr (显示 OXTR ELISA试剂盒) nuclear localization. This is required for Oxt (显示 OXT ELISA试剂盒)-induced osteoblast differentiation. osteoblast differentiation.
DJ-1 (显示 PARK7 ELISA试剂盒) import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (显示 HTT ELISA试剂盒) protein.
Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.
M9 region interaction protein
, importin 2
, importin beta 2
, importin beta-2
, karyopherin (importin) beta 2
, karyopherin beta-2
, transportin 1
, major intrinsic protein of lens fiber 1