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PHLPP2 抗体

(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
PHLPP2 抗体  (C-Term) PHLPP2 抗体  (C-Term) PHLPP2 抗体 (C-Term) (ABIN962593)

PHLPP2 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated

PHLPP2 抗体  (C-Term) PHLPP2 抗体  (C-Term) PHLPP2 抗体 (C-Term) (ABIN652395)

PHLPP2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB15007 unconjugated

PHLPP2 抗体  (C-Term) PHLPP2 抗体  (C-Term) PHLPP2 抗体 (C-Term) (ABIN190753)

Verified PHLPP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

PHLPP2 抗体 by Grade

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PHLPP2 抗体 by 适用

Find PHLPP2 抗体 for a variety of species such as anti-Human PHLPP2, anti-Mouse PHLPP2, anti-Rat PHLPP2. The species listed below are among those available. Click on a link to go to the corresponding products.

PHLPP2 抗体 by 应用范围

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PHLPP2 抗体 by 抗原表位

Find PHLPP2 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

PHLPP2 抗体 by 克隆形成能力

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PHLPP2 抗体 by 克隆

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Popular PHLPP2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IHC (p), IP
Validations
  • (2)
Cat. No. ABIN962593
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN652395
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN190753
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF
Validations
Cat. No. ABIN7117370
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN2764064
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, ICC
Validations
Cat. No. ABIN6991747
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IP
Validations
Cat. No. ABIN7450565
Quantity 20 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
Cat. No. ABIN7093950
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
Cat. No. ABIN1840309
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p), FACS
Validations
Cat. No. ABIN1810972
Quantity 400 μL
Datasheet Datasheet
Reactivity Guinea Pig, Human, Mouse, Rabbit
Application WB, IP
Validations
Cat. No. ABIN1923580
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, ICC
Validations
Cat. No. ABIN7466732
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN392229
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, EIA
Validations
  • (1)
Cat. No. ABIN1449986
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application IHC (p), EIA
Validations
  • (1)
Cat. No. ABIN360110
Quantity 0.4 mL
Datasheet Datasheet

Latest Publications for our PHLPP2 抗体

Rajala, Gupta, Anderson, Rajala: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).

Sangai, Akcakanat, Chen, Tarco, Wu, Do, Miller, Arteaga, Mills, Gonzalez-Angulo, Meric-Bernstam: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).

Gao, Furnari, Newton: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).

Aliases for PHLPP2 抗体

PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) 抗体
PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (phlpp2) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 抗体
AI481772 抗体
C130044A18Rik 抗体
PHLPPL 抗体
phlppl 抗体
Phlppl 抗体
RGD1562857 抗体
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