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Low PHLPP expression is associated with gallbladder cancer.
nickel exposure results in DNMT3b (显示 DNMT3B ELISA试剂盒) induction and MEG3 (显示 FAM129B ELISA试剂盒) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (显示 JUN ELISA试剂盒) and in turn increasing c-Jun (显示 JUN ELISA试剂盒) inhibition of PHLPP1 transcription, leading to the Akt (显示 AKT1 ELISA试剂盒)/p70S6K (显示 RPS6KB1 ELISA试剂盒)/S6 axis activation, and HIF-1alpha (显示 HIF1A ELISA试剂盒) protein translation, as well as malignant transformation of human bronchial epithelial cells.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (显示 RNF41 ELISA试剂盒)-mediated SGT1 (显示 SUGT1 ELISA试剂盒) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (显示 RNF41 ELISA试剂盒) = ring finger protein 41 (显示 RNF41 ELISA试剂盒); SGT1 (显示 SUGT1 ELISA试剂盒) = suppressor of G2 allele of SKP1 (显示 SUGT1 ELISA试剂盒))
Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (显示 AKT1 ELISA试剂盒), and thus suppress growth factor signaling.
During LPS (显示 IRF6 ELISA试剂盒) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (显示 PSG1 ELISA试剂盒) dependent transcriptional regulation.
results identify a novel role of PHLPP in regulating aPKC and cell polarity.
Abnormal PHLPP, FoxO3a (显示 FOXO3 ELISA试剂盒), and RAD51 (显示 RAD51 ELISA试剂盒) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.
this study shows that PHLPP1 played a suppression role in inflammatory response of glioma
Increased PHLPP expression is associated with pancreatic cancer.
our results suggest that PHLPP1 plays a crucial role in sacral chordoma
PHLPP1 reduced IFN-gamma (显示 IFNG ELISA试剂盒)-stimulated but not LPS (显示 TLR4 ELISA试剂盒)-induced ERK1/2 (显示 MAPK1/3 ELISA试剂盒) phosphorylation, and inhibition of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) abolished IFN-gamma-induced (显示 SAMHD1 ELISA试剂盒) ser (显示 SIGLEC1 ELISA试剂盒)(727) STAT1 (显示 STAT1 ELISA试剂盒) phosphorylation and iNOS (显示 NOS2 ELISA试剂盒) expression.
Phlpp1 deficiency increases Akt2 (显示 AKT2 ELISA试剂盒) activity, which diminishes FoxO1 (显示 FOXO1 ELISA试剂盒) levels and induces Fgf18 (显示 FGF18 ELISA试剂盒) expression to stimulate chondrocyte proliferation.
enhancing Akt (显示 AKT1 ELISA试剂盒) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy
data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.
SRPK1 (显示 SRPK1 ELISA试剂盒) overexpression is also tumorigenic because excess SRPK1 (显示 SRPK1 ELISA试剂盒) squelches PHLPP1.
PHLPP is a negative regulator of RAF1 (显示 RAF1 ELISA试剂盒), which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Histone deacetylase 3 (显示 HDAC3 ELISA试剂盒) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (显示 AKT1 ELISA试剂盒) signaling and matrix secretion
deletion of PHLPP1 can enhance Akt (显示 AKT1 ELISA试剂盒) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size
PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
PH domain and leucine rich repeat protein phosphatase 1
, PH domain leucine-rich repeat-containing protein phosphatase 1-like
, PH domain leucine-rich repeat-containing protein phosphatase 1
, PH domain-containing family E member 1
, SCN circadian oscillatory protein
, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
, suprachiasmatic nucleus circadian oscillatory protein
, pleckstrin homology domain-containing family E member 1
, Circadian Oscillatory Protein (SCOP)
, PH domain leucine-rich repeat protein phosphatase 1
, pleckstrin homology domain-containing family E protein 1