PHLPP1 (PHLPP1) ELISA试剂盒产品概述

Full name:
PH Domain and Leucine Rich Repeat Protein Phosphatase 1 ELISA试剂盒 (PHLPP1)
在www.antibodies-online.cn可供0 PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) ELISA试剂盒的不同的供货商。 再加上,我们可以发PHLPP1 抗体 (36)和数多这个蛋白质的别的产品。 总共43 PHLPP1产品已列进来了。
别名:
AI836256, mKIAA0606, Phlpp, Plekhe1, Scop
list all ELISA KIts 基因 基因ID UniProt
 PHLPP1 PHLPP1 23239 O60346
小鼠 PHLPP1 PHLPP1 98432 Q8CHE4
大鼠 PHLPP1 PHLPP1 59265 Q9WTR8

显示所有的同义词

适于 PHLPP1 相互作用对的更多 ELISA 试剂盒

Human PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) interaction partners

  1. nickel exposure results in DNMT3b (显示 DNMT3B ELISA试剂盒) induction and MEG3 (显示 FAM129B ELISA试剂盒) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (显示 JUN ELISA试剂盒) and in turn increasing c-Jun (显示 JUN ELISA试剂盒) inhibition of PHLPP1 transcription, leading to the Akt (显示 AKT1 ELISA试剂盒)/p70S6K (显示 RPS6KB1 ELISA试剂盒)/S6 axis activation, and HIF-1alpha (显示 HIF1A ELISA试剂盒) protein translation, as well as malignant transformation of human bronchial epithelial cells.

  2. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (显示 RNF41 ELISA试剂盒)-mediated SGT1 (显示 SUGT1 ELISA试剂盒) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (显示 RNF41 ELISA试剂盒) = ring finger protein 41 (显示 RNF41 ELISA试剂盒); SGT1 (显示 SUGT1 ELISA试剂盒) = suppressor of G2 allele of SKP1 (显示 SUGT1 ELISA试剂盒))

  3. Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt (显示 AKT1 ELISA试剂盒), and thus suppress growth factor signaling.

  4. During LPS (显示 IRF6 ELISA试剂盒) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (显示 PSG1 ELISA试剂盒) dependent transcriptional regulation.

  5. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  6. Abnormal PHLPP, FoxO3a (显示 FOXO3 ELISA试剂盒), and RAD51 (显示 RAD51 ELISA试剂盒) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.

  7. this study shows that PHLPP1 played a suppression role in inflammatory response of glioma

  8. Increased PHLPP expression is associated with pancreatic cancer.

  9. our results suggest that PHLPP1 plays a crucial role in sacral chordoma

  10. high levels of PHLPP might reflect a less aggressive lung adenocarcinoma phenotype and predict better survival in patients with lung adenocarcinoma.

Mouse (Murine) PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) interaction partners

  1. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  2. Phlpp1 deficiency increases Akt2 (显示 AKT2 ELISA试剂盒) activity, which diminishes FoxO1 (显示 FOXO1 ELISA试剂盒) levels and induces Fgf18 (显示 FGF18 ELISA试剂盒) expression to stimulate chondrocyte proliferation.

  3. enhancing Akt (显示 AKT1 ELISA试剂盒) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy

  4. data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.

  5. SRPK1 (显示 SRPK1 ELISA试剂盒) overexpression is also tumorigenic because excess SRPK1 (显示 SRPK1 ELISA试剂盒) squelches PHLPP1.

  6. PHLPP is a negative regulator of RAF1 (显示 RAF1 ELISA试剂盒), which reduces colorectal cancer cell motility and prevents tumor progression in mice.

  7. Histone deacetylase 3 (显示 HDAC3 ELISA试剂盒) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (显示 AKT1 ELISA试剂盒) signaling and matrix secretion

  8. deletion of PHLPP1 can enhance Akt (显示 AKT1 ELISA试剂盒) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size

  9. PHLPP1 has tumor suppressive activity and might represent a therapeutic or diagnostic tool for pancreatic ductal adenocarcinoma.

  10. PHLPP as a novel tumor suppressor.

PHLPP1 抗原简介

Antigen Summary

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Alternative names and synonyms associated with PHLPP1

  • PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) Elisa Kit
  • PH domain and leucine rich repeat protein phosphatase 1 (phlpp1) Elisa Kit
  • PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1) Elisa Kit
  • AI836256 Elisa Kit
  • mKIAA0606 Elisa Kit
  • Phlpp Elisa Kit
  • Plekhe1 Elisa Kit
  • Scop Elisa Kit

Protein level used designations for PHLPP1

PH domain and leucine rich repeat protein phosphatase 1 , PH domain leucine-rich repeat-containing protein phosphatase 1-like , PH domain leucine-rich repeat-containing protein phosphatase 1 , PH domain-containing family E member 1 , SCN circadian oscillatory protein , pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 , suprachiasmatic nucleus circadian oscillatory protein , pleckstrin homology domain-containing family E member 1 , Circadian Oscillatory Protein (SCOP) , PH domain leucine-rich repeat protein phosphatase 1 , pleckstrin homology domain-containing family E protein 1

GENE ID SPECIES
468563 Pan troglodytes
476179 Canis lupus familiaris
705882 Macaca mulatta
100483835 Ailuropoda melanoleuca
100497530 Xenopus (Silurana) tropicalis
100545158 Meleagris gallopavo
23239 Homo sapiens
98432 Mus musculus
59265 Rattus norvegicus
您还需要查找其他产品吗?