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Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
SIN1 plays an important role in non-small cell lung cancer; SIN1 is a potential biomarker and a promising target in the treatment of NSCLC
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin (显示 FRAP1 ELISA试剂盒) complex 2 (mTORC2 (显示 CRTC2 ELISA试剂盒)), is required for Interferon-gamma (显示 IFNG ELISA试剂盒)-induced phosphorylation and activation of AKT (显示 AKT1 ELISA试剂盒) and that such activation mediates downstream regulation of mTORC1 and its effectors.
Intracellular localization of mTORC2 (显示 CRTC2 ELISA试剂盒) component, mSin1, contributes to regulation of Akt (显示 AKT1 ELISA试剂盒) phosphorylation.
Akt (显示 AKT1 ELISA试剂盒) phosphorylates SIN1 at T86, enhancing mTORC2 (显示 CRTC2 ELISA试剂盒) kinase activity, which leads to phosphorylation of Akt (显示 AKT1 ELISA试剂盒) S473 by mTORC2 (显示 CRTC2 ELISA试剂盒), thereby catalyzing full activation of Akt (显示 AKT1 ELISA试剂盒).
MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica.
mitogen-activated protein kinase associated protein 1 rs10118570 may be an important protective factor for developing better management strategies in lung squamous cell carcinoma.
DNA-PKcs (显示 PRKDC ELISA试剂盒)-mTORC2 (显示 CRTC2 ELISA试剂盒)(SIN1) association is required for UVB-induced Akt (显示 AKT1 ELISA试剂盒) Ser (显示 SIGLEC1 ELISA试剂盒)-473 phosphorylation and cell survival.
Estradiol and mTORC2 (显示 CRTC2 ELISA试剂盒) cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2 (显示 TSC2 ELISA试剂盒)-deficient lymphangioleiomyomatosis cells.
results reveal a Sin1-phosphorylation-dependent mTORC2 (显示 CRTC2 ELISA试剂盒) regulation, providing a potential molecular mechanism by which mutations in the mTORC1-S6K (显示 RPS6KB1 ELISA试剂盒)-Sin1 signalling axis might cause aberrant hyper-activation of the mTORC2 (显示 CRTC2 ELISA试剂盒)-Akt (显示 AKT1 ELISA试剂盒) pathway
NBS1 (显示 NBN ELISA试剂盒) interacts with the mTOR (显示 FRAP1 ELISA试剂盒)/Rictor (显示 RICTOR ELISA试剂盒)/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt (显示 AKT1 ELISA试剂盒) activity.
analysis of mTORC2 (显示 CRTC2 ELISA试剂盒) components mTOR (显示 FRAP1 ELISA试剂盒), Rictor (显示 RICTOR ELISA试剂盒) and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
data suggest that DNA-PKcs (显示 PRKDC ELISA试剂盒)-SIN1 complexation-mediated Akt (显示 AKT1 ELISA试剂盒) activation (Ser (显示 SIGLEC1 ELISA试剂盒)-473 phosphorylation) is required for mouse osteoblast differentiation
these findings provide evidence for critical functions for Rictor (显示 RICTOR ELISA试剂盒)/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
The phosphorylation of SIN1 by Akt (显示 AKT1 ELISA试剂盒) was found to regulate mTORC2 (显示 CRTC2 ELISA试剂盒) activity in response to growth factors, revealing topological insights into the Akt (显示 AKT1 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) signaling network.
Sin1 and mTORC2 (显示 CRTC2 ELISA试剂盒) are dispensable for the development and activation of T cells but play a role in nTreg-cell differentiation.
mSIN1 protein mediates SGK1 (显示 SGK1 ELISA试剂盒) protein interaction with mTORC2 (显示 CRTC2 ELISA试剂盒) protein complex and is required for selective activation of the epithelial sodium channel
MAP kinase (显示 MAPK1 ELISA试剂盒)-interacting kinase 1 and 2 activity enhances formation of the EIF-4F complex in pachytene spermatocytes but not in round spermatids.
Sin1-mTORC2 (显示 CRTC2 ELISA试剂盒) suppresses rag1,2 and il7r (显示 IL7R ELISA试剂盒) gene expression through Akt2 (显示 AKT2 ELISA试剂盒) in B cells.
Results reveal that the SIN1-rictor (显示 RICTOR ELISA试剂盒)-mTOR (显示 FRAP1 ELISA试剂盒) function in Akt (显示 AKT1 ELISA试剂盒)-Ser473 phosphorylation is required for TORC2 (显示 CRTC2 ELISA试剂盒) function in cell survival but is dispensable for TORC1 (显示 CRTC1 ELISA试剂盒) function.
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.
, Stress-activated protein kinase [SAPK]-interacting protein
, stress-activated map kinase-interacting protein 1
, mitogen-activated protein kinase associated protein 1
, Target of rapamycin complex 2 subunit MAPKAP1
, target of rapamycin complex 2 subunit MAPKAP1-like
, MEKK2-interacting protein 1
, SAPK-interacting protein 1
, TORC2 subunit MAPKAP1
, mitogen-activated protein kinase 2-associated protein 1
, ras inhibitor MGC2745
, stress-activated map kinase interacting protein 1
, stress-activated protein kinase-interacting 1
, target of rapamycin complex 2 subunit MAPKAP1
, mitogen activated protein kinase associated protein 1
, SAPK interacting protein