Glycogen Synthase 1 (GYS1) ELISA试剂盒产品概述

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Glycogen Synthase 1 (Muscle) ELISA试剂盒 (GYS1)
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别名:
GSY, GYS, GYS1, GYS2, Gys3, MGS, zgc:63701

Glycogen Synthase 1 (GYS1) ELISA试剂盒 by Reactivity

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Pig (Porcine) Glycogen Synthase 1 (Muscle) (GYS1) interaction partners

  1. Expression analysis revealed that porcine GYS1 was highly expressed in the skeletal muscle and heart

Horse (Equine) Glycogen Synthase 1 (Muscle) (GYS1) interaction partners

  1. the occurrence of the mutated GYS1 allele is influenced by coat colour

  2. The GYS1 mutation was detected in 11 breeds; with prevalence of genetic susceptibility to Type 1 Polysaccharide Storage Myopathy varied from 0.5% to 62.4%.

  3. observed that the two miRNAs, namely, eca-miR (显示 MYLIP ELISA试剂盒)-33a and miR-17, inhibited LDHA (显示 LDHA ELISA试剂盒) and GYS1 expression via binding to the 3' UTR (显示 UTS2R ELISA试剂盒) sequences of each gene

  4. The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.

  5. Study identified GYS1, encoding skeletal muscle glycogen synthase (GS), as a candidate gene for Polysaccharide storage myopathy; DNA sequence analysis revealed a mutation resulting in an Arg-to-his substitution in a highly conserved region of GS.

  6. The prevalence of a missense mutation of GYS1 in horses with polysaccharide storage myopathy and the prevalence of the mutation based on disease classification are reported.

  7. This GYS1 point mutation appears to cause a gain-of-function of the enzyme and to result in the accumulation of a glycogen-like, less-branched polysaccharide in skeletal muscle.

  8. The GYS1 mutation is an important cause of exertional rhabdomyolysis in UNited Kingdom horse breeds but does not account for all forms of polysaccharide storage myopathy.

Human Glycogen Synthase 1 (Muscle) (GYS1) interaction partners

  1. Overexpression of GYS1, MIF (显示 AMH ELISA试剂盒), and MYC (显示 MYC ELISA试剂盒) is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia (显示 BCL11A ELISA试剂盒)

  2. over-expression of muscle glycogen synthase (MGS)was detected in diabetic human kidney

  3. High glycogen synthase 1 expression is associated with myeloid leukemia (显示 BCL11A ELISA试剂盒).

  4. Data suggest that although COOH-terminal dephosphorylation is likely necessary for GS activation, protein kinase Akt-2- (Akt2 (显示 AKT2 ELISA试剂盒))-dependent NH2-terminal dephosphorylation is site for "fine-tuning" insulin (显示 INS ELISA试剂盒)-mediated GS activation in skeletal muscle.

  5. Allosteric regulation and the relationship between phosphorylation and the kinetics of glycogen synthase. [Review]

  6. The present findings demonstrate that physical inactivity-induced insulin (显示 INS ELISA试剂盒) resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage.

  7. GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2 (显示 UGP2 ELISA试剂盒)) and 1,4-alpha glucan branching enzyme (GBE1 (显示 GBE1 ELISA试剂盒))

  8. Exercise unmaskd the effect associated with the GYS1 polymorphism, rendering carriers of this allele less susceptible to the protective effect of exercise on the risk of cardiovascular mortality.

  9. the M416V polymorphism of glycogen synthase 1 gene is not associated with insulin (显示 INS ELISA试剂盒) resistance in type 2 diabetes

  10. Data show that myotubes defective in glycogen synthase (GS) activity express insulin (显示 INS ELISA试剂盒)-responsive glycogen synthase kinase-3alpha, suggesting that failure of insulin (显示 INS ELISA试剂盒) to decrease GS phosphorylation involves abnormal activity of another kinase or phosphatase.

Mouse (Murine) Glycogen Synthase 1 (Muscle) (GYS1) interaction partners

  1. These results demonstrate that pharmacological agents that activate GYS1, the main GS subtype found in skeletal muscle, have potential for use as novel treatments for diabetes that improve glucose metabolism in skeletal muscle.

  2. We show that the absence of Epm2aip1 (显示 EPM2AIP1 ELISA试剂盒) in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin (显示 INS ELISA试剂盒) resistance, and protects against age-related obesity

  3. Muscle glycogen synthase isoform is responsible for testicular glycogen synthesis: glycogen overproduction induces apoptosis in male germ cells.

  4. Long-term potentiation (LTP (显示 SCP2 ELISA试剂盒)) evoked in the hippocampal CA3 (显示 CA3 ELISA试剂盒)-CA1 (显示 CA1 ELISA试剂盒) synapse was also decreased in behaving GYS1(Nestin (显示 NES ELISA试剂盒)-KO) mice.

  5. Neurodegeneration and functional impairments are associated with glycogen synthase accumulation in the mouse model of Lafora disease.

  6. GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2 (显示 UGP2 ELISA试剂盒)) and 1,4-alpha glucan branching enzyme (GBE1 (显示 GBE1 ELISA试剂盒))

  7. Overexpression of glycogen synthase in skeletal muscle results in less branched glycogen.

  8. The endogenous glycogen synthase in extracts from mouse brain bound specifically to SAPK2b/p38b (显示 MAPK11 ELISA试剂盒) & was phosphorylated at residues Ser644, Ser652, Thr718 and Ser724.

  9. JNK signaling regulates the phosphorylation state of several kinases in skeletal muscle. JNK activation is unlikely to be the major mechanism by which contractile activity increases glycogen synthase activity in skeletal muscle.

  10. the GYS1 gene is not essential for strenuous exercise and has relatively little effect on endurance in mice

Glycogen Synthase 1 (GYS1) 抗原简介

Antigen Summary

The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Glycogen Synthase 1 (GYS1)

  • glycogen synthase 1 (muscle) (GYS1) Elisa Kit
  • glycogen synthase 1 (muscle) (gys1) Elisa Kit
  • glycogen synthase 1, muscle (Gys1) Elisa Kit
  • GSY Elisa Kit
  • GYS Elisa Kit
  • GYS1 Elisa Kit
  • GYS2 Elisa Kit
  • Gys3 Elisa Kit
  • MGS Elisa Kit
  • zgc:63701 Elisa Kit

Protein level used designations for GYS1

glycogen [starch] synthase, muscle , glycogen synthase 1 (muscle) , glycogen synthase 3, brain

GENE ID SPECIES
574064 Sus scrofa
456196 Pan troglodytes
394155 Danio rerio
378934 Gallus gallus
100054723 Equus caballus
100172871 Pongo abelii
511047 Bos taurus
611993 Canis lupus familiaris
2997 Homo sapiens
786335 Bos taurus
100008660 Oryctolagus cuniculus
574233 Macaca mulatta
14936 Mus musculus
690987 Rattus norvegicus
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