Use your antibodies-online credentials, if available.
Select your species
Studies provide evidence that Deptor appears to play an important role in the pathogenesis of many types of cancers, mainly through its role in controlling the activity of mTOR (显示 FRAP1 ELISA试剂盒) and many other possible functions. [review]
Low DEPTOR expression is associated with esophageal squamous cell carcinoma.
Association between insulin (显示 INS ELISA试剂盒) sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin (显示 FRAP1 ELISA试剂盒) signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR (显示 EGFR ELISA试剂盒)-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR (显示 FRAP1 ELISA试剂盒) signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR (显示 FRAP1 ELISA试剂盒) pathway components, mTOR (显示 FRAP1 ELISA试剂盒), DEPTOR, rictor (显示 RICTOR ELISA试剂盒) and raptor (显示 RPTOR ELISA试剂盒), at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 (显示 CUL1 ELISA试剂盒) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin (显示 INS ELISA试剂盒) resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC (显示 POMC ELISA试剂盒) neurons. Taken together, these results show that DEPTOR overexpression in POMC (显示 POMC ELISA试剂盒) neurons does not affect energy balance regulation but could modu
The present study indicates that regulation of DEPTOR/mTOR (显示 FRAP1 ELISA试剂盒) signaling may be an important mechanism for glutamine (显示 GFPT1 ELISA试剂盒) in prevention against the development of colitis-associated colorectal cancer (CAC (显示 SLC25A20 ELISA试剂盒)): the chemopreventive effect of dietary glutamine (显示 GFPT1 ELISA试剂盒) on CAC (显示 SLC25A20 ELISA试剂盒) is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (显示 NFkBP65 ELISA试剂盒).
p38gamma (显示 MAPK12 ELISA试剂盒) and p38delta (显示 MAPK1/3 ELISA试剂盒) control heart growth by modulating mTOR (显示 FRAP1 ELISA试剂盒) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (显示 FRAP1 ELISA试剂盒) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (显示 FRAP1 ELISA试剂盒) kinase substrates, 4E-BP1 (显示 EIF4EBP1 ELISA试剂盒) and S6K1 (显示 RPS6KB1 ELISA试剂盒), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4