Use your antibodies-online credentials, if available.
Human Cyclin D1 Protein expressed in Wheat germ - ABIN1348445
Dannenmann, Hermanns, Bransi, Matter, von Boehmer, Stevanovic, Schraml, Moch, Knuth, van den Broek: Spontaneous peripheral T-cell responses toward the tumor-associated antigen cyclin D1 in patients with clear cell renal cell carcinoma. in Cancer immunology research 2014
Results suggest that the TCF (显示 HNF4A 蛋白)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (显示 CCNDBP1 蛋白) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (显示 SMC1A 蛋白) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (显示 MEIS1 蛋白) regulating cyclin D1 and c-myc (显示 MYC 蛋白) transcription in the embryonic eye.
CCND1 plays these essential roles likely through involvement in DNA replication to minimize DNA damage.
MiR (显示 MLXIP 蛋白)-374a inactivates the PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) axis by inhibiting CCND1, suppressing of colon cancer progression.
Overexpression of cyclin D1 results in dysregulated CDK (显示 CDK4 蛋白) activity, rapid cell growth under conditions of restricted mitogenic signaling, bypass of key cellular checkpoints, and ultimately, neoplastic growth. (Review)
a RAGE (显示 AGER 蛋白)-dependent polyP-mediated crosstalk between mTOR (显示 FRAP1 蛋白) and the GSK-3/Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling network can modulate important physiological processes in endothelial cells that involve cyclin D1
Results indicate that miR (显示 MLXIP 蛋白)-134 played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic CCND1.
Patients with tumors with high amplification of CCND1 had an increased risk of recurrence. These findings suggest that CCND1 amplification could be useful for predicting recurrence in invasive breast cancer
Data suggest that subcellular localization of cyclin D1 (Ccnd1) is an interesting guideline to measure cancer outcome.
MEK2 (显示 MAP2K2 蛋白) was essential for the phosphorylation of MKK3 (显示 MAP2K3 蛋白)/MKK6 (显示 MAP2K6 蛋白) and p38 MAPK (显示 MAPK14 蛋白) that directly impacted on cyclin D1 expression.
miR (显示 MLXIP 蛋白)-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2 (显示 KDM5A 蛋白)/NOTCH1 (显示 NOTCH1 蛋白)/CYCLIN D1 coregulatory network.
Findings indicate cyclin D1 (CCND1) as a target of microRNA miR (显示 MLXIP 蛋白)-1296.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF (显示 CSF1R 蛋白)/c-Fms (显示 CSF1R 蛋白)-mediated downstream signaling pathways like activation of ERK (显示 EPHB2 蛋白) and Akt (显示 AKT1 蛋白) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (显示 CTNNB1 蛋白)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (显示 PAX5 蛋白) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (显示 POU5F1 蛋白), Sox2 (显示 SOX2 蛋白), Klf4 (显示 KLF4 蛋白), and c-Myc (显示 MYC 蛋白) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (显示 PLCG1 蛋白) controls osteoclast numbers via a CSF-1 (显示 CSF1 蛋白)-dependent DAG/beta-catenin (显示 CTNNB1 蛋白)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (显示 MYC 蛋白), Cyc (显示 CYCS 蛋白)-D1 and TERT (显示 TERT 蛋白), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (显示 DND1 蛋白) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (显示 IL33 蛋白).
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (显示 CDK2 蛋白) and CDK4 (显示 CDK4 蛋白) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (显示 MAPK3 蛋白) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1