Use your antibodies-online credentials, if available.
Select your species
Human Cyclin D1 ELISA Kit for Sandwich ELISA - ABIN414406
Bocci, Fioravanti, La Motta, Orlandi, Canu, Di Desidero, Mugnaini, Sartini, Cosconati, Frati, Antonelli, Berti, Miccoli, Da Settimo, Danesi: Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. in Biochemical pharmacology 2011
Show all 5 Pubmed References
Results suggest that the TCF (显示 HNF4A ELISA试剂盒)/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
Maid (显示 CCNDBP1 ELISA试剂盒) is important regulator of hepatocarcinogenesis and aging
show that the knockdown of smc1a (显示 SMC1A ELISA试剂盒) in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 (显示 MEIS1 ELISA试剂盒) regulating cyclin D1 and c-myc (显示 MYC ELISA试剂盒) transcription in the embryonic eye.
This meta-analysis suggests that the CCND1 G870A polymorphism is associated with an increased risk of colorectal cancer, especially that A carriers may be a major risk factor for colorectal cancer.
results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. Treatment with fascaplysin also suppressed CDK4 (显示 CDK4 ELISA试剂盒), cyclin D1, Bcl-2 (显示 BCL2 ELISA试剂盒), and VEGFA (显示 VEGFA ELISA试剂盒) expression at protein levels
Mutation in the CCND1 gene is associated with acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
The first preclinical study evaluates the response to CDK4/6 (显示 CDK4 ELISA试剂盒) inhibition in endometrial malignancies driven by PTEN deficiency, and it reveals an important role of cyclin D-CDK4/6 (显示 CDK4 ELISA试剂盒) activity in their development.
High CCND1 expression is associated with oropharyngeal squamous cell carcinoma.
Describe a regulatory loop miR (显示 MLXIP ELISA试剂盒)-218-CDK6 (显示 CDK6 ELISA试剂盒)/CyclinD1-E2F1 (显示 E2F1 ELISA试剂盒) whose disruption may contribute to cell cycle progression in gastric cancer.
EGF induces hair follicle-derived mesenchymal stem cell proliferation through the EGFR/ERK and AKT pathways, but not through STAT-3. The G1/S transition was stimulated by upregulation of cyclinD1 and inhibition of p16 expression.
Case Report: in the absence of the typical CCND1/IGH@ fusion, t(11;12)(q13;p11.2) promotes Mantle cell lymphoma pathogenesis by eliminating miRNA interaction elements within the 3'-UTR (显示 UTS2R ELISA试剂盒) of the CCND1 mRNA transcript consequently resulting in CCND1 overexpression.
The CCND1 genes were found very close to the IGH locus in naive B cells and further away after maturation. In contrast, the CMYC alleles became localized closer to an IGH locus at the stage of SHM/CSR.
Consistently, samples from oral squamous cell carcinoma (OSCC) patients exhibited a noticeably stronger CREPT expression than noncancerous samples. In contrast, knocking down of CREPT in OSCC cell lines significantly reduced proliferation, colony formation and migration as well as the expression of cyclin D1 and c-Myc (显示 MYC ELISA试剂盒), but promoted apoptosis.
NMB or NMBR (显示 NMBR ELISA试剂盒) silencing inhibited M-CSF (显示 CSF1R ELISA试剂盒)/c-Fms (显示 CSF1R ELISA试剂盒)-mediated downstream signaling pathways like activation of ERK (显示 EPHB2 ELISA试剂盒) and Akt (显示 AKT1 ELISA试剂盒) and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1 (显示 CTNNB1 ELISA试剂盒)-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 (显示 PAX5 ELISA试剂盒) and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4 (显示 POU5F1 ELISA试剂盒), Sox2 (显示 SOX2 ELISA试剂盒), Klf4 (显示 KLF4 ELISA试剂盒), and c-Myc (显示 MYC ELISA试剂盒) (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 (显示 PLCG1 ELISA试剂盒) controls osteoclast numbers via a CSF-1 (显示 CSF1 ELISA试剂盒)-dependent DAG/beta-catenin (显示 CTNNB1 ELISA试剂盒)/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (显示 MYC ELISA试剂盒), Cyc (显示 CYCS ELISA试剂盒)-D1 and TERT (显示 TERT ELISA试剂盒), respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma (显示 DND1 ELISA试剂盒) susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33 (显示 IL33 ELISA试剂盒).
Novel RNA-binding activity of MYF5 (显示 MYF5 ELISA试剂盒) enhances Ccnd1 mRNA translation during myogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 (显示 CDK2 ELISA试剂盒) and CDK4 (显示 CDK4 ELISA试剂盒) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 (显示 MAPK3 ELISA试剂盒) kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, Cyclin-D1-binding protein 1 homolog
, cyclin Dx
, cyclin-D1-binding protein 1 homolog
, zebrafish homolog of Maid
, cyclin D1
, G1/S-specific cyclin-D1
, B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, PRAD1 oncogene
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)