Ubiquitin Specific Peptidase 20 (USP20) (Middle Region) Peptide
USP20
适用: 人
宿主: 合成
BP, WB
-
- 抗原 See all USP20 products
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- 蛋白结构域
- Middle Region
- 宿主
- 人
-
资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- PAEAQPPSPR SSSPCRTPEP DNDAHLRSSS RPCSPVHHHE GHAKLSSSPP
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-USP20 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
-
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- 抗原
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- 背景
-
USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Alias Symbols: KIAA1003, LSFR3A, VDU2
Protein Interaction Partner: DIO2,PRKCI,ACADM,APBA2,ATAD3B,ATP6AP2,CALM1,DIO2,EIF3C,EIF3E,FECH,GPT2,HERC2,HERC2P2,HIF1A,LRRC59,MAP7D1,MYO1A,MYO1C,N4BP3,NEURL4,NUP153,PECI,PLEC,PLEKHA7,PLK1,POLDIP3,PSMD11,PSMD12,PSMD6,PSMD7,RAD17,RFC2,RFC3,RFC4,RGPD5,SUN2,SYTL4,UCHL3,USP21,VAPA,VAPB,V
Protein Size: 913 - 分子量
- 102 kDa
- 基因ID
- 10868
- NCBI登录号
- NM_006676, NP_006667
- UniProt
- Q9Y2K6
-
You are here:
