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Sirtuin 6 (SIRT6) (Middle Region) Peptide

SIRT6 适用: 人 宿主: 合成 BP, WB
产品编号 ABIN983773
发货至: 中国
  • 抗原 See all SIRT6 products
    SIRT6 (Sirtuin 6 (SIRT6))
    蛋白结构域
    Middle Region
    宿主
    资源
    • 1
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB)
    产品特性
    This is a synthetic peptide designed for use in combination with anti-SIRT6 antibody (Catalog #: ARP32408_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    SIRT6 (Sirtuin 6 (SIRT6))
    别名
    2810449N18Rik Peptide, AI043036 Peptide, Sir2l6 Peptide, SIR2L6 Peptide, zgc:86729 Peptide, sirtuin 6 Peptide, sirtuin 6 S homeolog Peptide, Sirt6 Peptide, SIRT6 Peptide, sirt6.S Peptide, sirt6 Peptide
    背景
    SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

    Alias Symbols: SIR2L6

    Protein Interaction Partner: CHD3,ELF5,VIM,CHD3,ELF5,PRKDC,VIM,XRCC5,XRCC6

    Protein Size: 355
    分子量
    39 kDa
    基因ID
    51548
    NCBI登录号
    NM_016539, NP_057623
    UniProt
    Q8N6T7
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