SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptide

ABIN983535 产品详细信息, 供应商: Log in to see
蛋白名称
  • 2810017C20Rik
  • E130319N12Rik
  • Susp1
  • mKIAA0797
  • SSP1
  • SUSP1
  • SUMO1/sentrin specific peptidase 6
  • SUMO/sentrin specific peptidase 6
  • SENP6
  • Senp6
蛋白结构域
C-Term
宿主
人, 小鼠
4
3
2
1
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
选项
Supplier
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Supplier Product No.
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Blocked Antibody anti-SENP6 抗体 (SUMO1/sentrin Specific Protease 6) (C-Term) (ABIN2784244)
序列 LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
产品特性 This is a synthetic peptide designed for use in combination with anti-Senp6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
纯化方法 Purified
背景 Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797

Protein Size: 1132
分子量 127 kDa
基因ID 215351
NCBI登录号 NM_146003, NP_666115
UniProt Q6P7W0
应用备注 Each Investigator should determine their own optimal working dilution for specific applications.
限制 仅限研究用
状态 Lyophilized
溶解方式 Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
浓度 1 mg/mL
缓冲液 Final peptide concentration is 1 mg/mL in PBS.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.