电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (Middle Region) Peptide

RFWD2 适用: 小鼠 宿主: 合成 BP, WB
产品编号 ABIN982884
发货至: 中国
  • 抗原 See all RFWD2 products
    RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
    蛋白结构域
    Middle Region
    宿主
    小鼠
    资源
    • 3
    合成
    应用范围
    Blocking Peptide (BP), Western Blotting (WB)
    序列
    MSGLYSPVSE DSTVPQFEAP SPSHSSIIDS TEYSQPPGFS GTSQTKKQPW
    产品特性
    This is a synthetic peptide designed for use in combination with anti-Rfwd2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    纯化方法
    Purified
  • 应用备注
    Each Investigator should determine their own optimal working dilution for specific applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    浓度
    1 mg/mL
    缓冲液
    Final peptide concentration is 1 mg/mL in PBS.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • 抗原
    RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
    别名
    COP1 Peptide, RNF200 Peptide, AI316802 Peptide, C80879 Peptide, Cop1 Peptide, RGD1304773 Peptide, RFWD2 Peptide, cop1 Peptide, rnf200 Peptide, zgc:163067 Peptide, ring finger and WD repeat domain 2 Peptide, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase Peptide, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog Peptide, RFWD2 Peptide, Rfwd2 Peptide, rfwd2 Peptide, rfwd2.L Peptide
    背景
    Rfwd2 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It is involved in JUN ubiquitination and degradation and directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Rfwd2 probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.

    Alias Symbols: AI316802, C80879, Cop1

    Protein Size: 733
    分子量
    80 kDa
    基因ID
    26374
    NCBI登录号
    NM_011931, NP_036061
    UniProt
    Q9R1A8
You are here:
客服