Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) Peptide
FZR1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all FZR1 products
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- SSPVSSPSKH GDRFIPSRAG ANWSVNFHRI NENEKSPSQN RKAKDATSDN
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-FZR1 Antibody(ARP51279_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 别名
- CDH1-C Peptide, FYR Peptide, FZR Peptide, CDH1 Peptide, fzr1 Peptide, CDC20C Peptide, FZR2 Peptide, HCDH Peptide, HCDH1 Peptide, AW108046 Peptide, Cdh1 Peptide, Fyr Peptide, zgc:55450 Peptide, fizzy and cell division cycle 20 related 1 Peptide, fizzy/cell division cycle 20 related 1 Peptide, fizzy-related protein homolog Peptide, fizzy/cell division cycle 20 related 1 (Drosophila) Peptide, fizzy/cell division cycle 20 related 1a Peptide, Fzr1 Peptide, CDH1-C Peptide, FZR1 Peptide, LOC100027495 Peptide, LOC100179951 Peptide, fzr1a Peptide
- 背景
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FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Protein Interaction Partner: CCNB1,CDC27,NEDD9,ANAPC2,C7orf25,CCNB1,CDC14A,CDC27,CDK2,DNAJA1,FBXO5,SKIL,SKP2,SKP2,ANAPC1,ANAPC2,ANAPC4,ANAPC5,ANAPC7,CDC14A,CDC20,CDC27,CDT1,FBXO5,MAD2L2,SKIL,TPX2
Protein Size: 493 - 分子量
- 55 kDa
- 基因ID
- 51343
- NCBI登录号
- NM_016263, NP_057347
- UniProt
- Q9UM11
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