Unc-51 Like Kinase 1 (ULK1) (N-Term) Peptide
ULK1
适用: 人
宿主: 合成
BP, WB
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- 抗原 See all ULK1 products
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- 蛋白结构域
- N-Term
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-ULK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- 背景
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ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Protein Size: 1050 - 分子量
- 112 kDa
- 基因ID
- 8408
- NCBI登录号
- NM_003565, NP_003556
- UniProt
- O75385
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