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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (显示 NCS1 ELISA试剂盒) in mitochondrial function via its association with several mitochondrial proteins.
These observations provide evidence that the synaptobrevin-2 transmembrane domain catalyzes the membrane fusion process by its structural flexibility, actively setting the pace of fusion pore expansion.
Syp1 (显示 SYP ELISA试剂盒) clears Syb2 from the presynaptic active zone to prevent short-term depression.
The balance between synaptophysin (显示 SYP ELISA试剂盒) and sybII levels is critical for the correct targeting of sybII to synaptic vesicles and suggests that alterations in synaptophysin (显示 SYP ELISA试剂盒) levels might affect the localisation of sybII and subsequent presynaptic performance.
Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD (显示 TTN ELISA试剂盒) greatly improves its function
Vamp2 mutations impair the ability of Munc18-1 (显示 STXBP1 ELISA试剂盒) to promote trans-SNARE (显示 VTI1B ELISA试剂盒) zippering. These mutations inhibit spontaneous as well as evoked neurotransmitter release, providing evidence for the Vamp2-regulating function of Munc18-1 (显示 STXBP1 ELISA试剂盒) in synaptic exocytosis.
These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin (显示 INS ELISA试剂盒) secretion.
Results suggest that side chains in the syb2 transmembrane domain influence the kinetics of exocytosis by perturbing the packing of the surrounding lipids
we demonstrate that Syb2 and SNAP25 (显示 SNAP25 ELISA试剂盒) mediate the vesicular release of BDNF (显示 BDNF ELISA试剂盒) in axons and dendrites of cortical neurons
Here we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb2) that develop progressive degeneration of motor nerve terminals.
VAMP2 is the major v-SNARE (显示 GOSR1 ELISA试剂盒) involved in GLUT4 (显示 SLC2A4 ELISA试剂盒) trafficking to the surface of 3T3-L1 adipocytes.
Data suggest that A-syn (显示 FYN ELISA试剂盒) (alpha-synuclein) promotes SNARE (显示 NAPA ELISA试剂盒)-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE (显示 NAPA ELISA试剂盒)-bearing vesicles causes A-syn (显示 FYN ELISA试剂盒) to inhibit vesicle docking; PS removal from v-SNARE (显示 VTI1B ELISA试剂盒)-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn (显示 FYN ELISA试剂盒) are required for promotion of vesicle docking. (Here, t-SNARE (显示 NAPA ELISA试剂盒) is SNAP-25 (显示 SNAP25 ELISA试剂盒); v-SNARE (显示 VTI1B ELISA试剂盒) is VAMP2.)
A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC (显示 COL4A1 ELISA试剂盒) variants in all epilepsy cases.
VAMP2 is a promising new plasma cell marker
VAMP2 is involved in Porphyromonas gingivalis recycling pathway.VAMP2 is localized in early endosomes in gingival epithelial cells.
The present study addressed for the first time the unique substrate recognition mechanism of LC/F5 substrate cleavage of VAMP-2 by Botulinum Neurotoxin subtype F5.
This study showed that decreased Levels of VAMP2 correlate with Duration of Dementia.
VAMP2-NRG1 (显示 NRG1 ELISA试剂盒) is a novel oncogenic fusion gene representing a new addition to the list of NRG1 (显示 NRG1 ELISA试剂盒) fusion genes, which together may form an important diagnostic and clinical category of lung adenocarcinoma cases
A large vesicular pool of VAMP2 maintained by AP180 (显示 SNAP91 ELISA试剂盒) is crucial to sustain efficient neurotransmission.
SNARE (显示 NAPA ELISA试剂盒) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
miR (显示 MLXIP ELISA试剂盒)-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.
VAMP-2 is critical to lysosome fusion in membrane raft clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function.
VAMP2 is restricted from forming the SNARE (显示 NAPA ELISA试剂盒) (soluble N-ethylmaleimide-sensitive fusion protein (显示 NSF ELISA试剂盒) attachment protein receptor) complex in chromaffin granules from adrenal medullae to the same degree as in brain-purified synaptic vesicles.
Lengthening juxtamembrane region of synaptobrevin-2 severely reduced occurrence of rapid single events, leaving slow ones unchanged. It also impaired increase in fast-fusion mode that normally follows elevation of intracellular Ca2 (显示 CA2 ELISA试剂盒)+ levels.
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
vesicle-associated membrane protein 2 (synaptobrevin 2)
, synaptobrevin II
, vesicle-associated membrane 2
, Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2)
, Vesicle-associated membrane protein (synaptobrevin 2)
, synaptobrevin 2
, vesicle associated membrane protein 2
, vesicle-associated membrane protein 2