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抗Mouse (Murine) 抗体:
Mouse (Murine) Polyclonal STX1A Primary Antibody for ELISA, WB - ABIN269841
Kang, Leung, Manning-Fox, Xia, Xie, Sheu, Tsushima, Light, Gaisano: Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. in The Journal of biological chemistry 2004
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
A significant interactive two-locus model of STX1A_rs4363087|VAMP2_rs2278637 (presynaptic genes) was observed among SVC (显示 COL4A1 抗体) variants in all epilepsy cases.
Mislocalization of syntaxin-1 was found in pluripotent stem cells from epileptic encephalopathy patient.
Blockade of the SNARE (显示 NAPA 抗体) protein syntaxin 1 inhibits glioblastoma tumor growth.
SNARE (显示 NAPA 抗体) complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD.
We described clinical, genetic, and functional data from 17 families with a diagnosis of benign familial neonatal epilepsy caused by KCNQ2 (显示 KCNQ2 抗体) or KCNQ3 (显示 KCNQ3 抗体) mutations and we showed that some mutations lead to a reduction of Q2 channel regulation by syntaxin-1A.
no associaton with idiopathic generalized epilepsy was found regarding Intron 7 rs1569061 of Syntaxin 1A gene, MnlI rs3746544 and DdeI rs1051312 polymorphisms of SNAP-25 (显示 SNAP25 抗体) gene compared with healthy subjects
The clinical relevance of STX1A variants in CF
PIP2 affects islet beta-cell KATP channels not only by its actions on Kir6.2 but also by sequestering Syn-1A to modulate Syn-1A availability and its interactions with SUR1 on PM.
Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE (显示 NAPA 抗体) complex fusion intermediate.
Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer
microdomains carrying syntaxin1/SNAP-25 (显示 SNAP25 抗体) and different types of calcium channels act as the sites for physiological granule fusion in "in situ" chromaffin cells
The role of syntaxin 1A in GLP1 (显示 GCG 抗体) release from intestinal cells as a response to external stimuli is reported.
proteins, such as syntaxin-1, Munc18-1, or SNAP-25, modulate alpha-synuclein neuropathy and/or are dysregulated in Alzheimer's disease, understanding this type of neurodegeneration may provide new links between synaptic defects and neurodegeneration in humans
Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion.
Syn (显示 SYP 抗体)-1A actions on newcomer SGs (显示 SKI 抗体) were partly mediated by Syn (显示 SYP 抗体)-1A interactions with newcomer SG VAMP8 (显示 VAMP8 抗体)
The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system.
Data suggest that porosome-associated proteins SNAP25 (显示 SNAP25 抗体), TREK-1 (显示 KCNK2 抗体), syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin (显示 INS 抗体)-secreting porosomes in cell membrane of live cells.
syntaxin 1 and vesicle-associated membrane protein 1 (显示 VAMP1 抗体) are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor (显示 VTI1B 抗体) complexes
Data show a significant increase of vesicle-associated membrane protein 2 (VAMP-2 (显示 VAMP2 抗体)) mRNA expression, however, the expressions of synaptosome-associated protein of 25 kDa (SNAP-25 (显示 SNAP25 抗体)) and syntaxin 1A did not exhibit the changes in hippocampus.
Although STX1A and STX1B (显示 STX1B 抗体) share a basic function as neuronal t-SNAREs, STX1B (显示 STX1B 抗体) but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
we found that STX1A and STX1B (显示 STX1B 抗体) play distinct roles in neuronal survival using
The authors found two syntaxin1A mutations that confer opposite general anesthesia phenotypes
Data suggest that Ca(2 (显示 CA2 抗体)+)-CaM regulation of V100 may control SNARE (显示 NAPA 抗体) complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
these results indicate that SNAP-25 (显示 SNAP25 抗体)-R206 and syntaxin (显示 STX4 抗体)-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE (显示 NAPA 抗体) complexes interacting via the ionic couple formed by these two residues.
Syntaxin1A domain formation is induced by phosphoinositide-3,4,5-triphosphate; this clustering is dependent on positively charged residues in the juxtamembrane domain.
The Syx1A dependent trafficking of Grk (显示 GRK4 抗体) protein is required for efficient EGFR (显示 EGFR 抗体) signaling during dorsal-ventral patterning.
analysis of epistatic interactions related to mutation of Syx1A
Syntaxin 1A molecules share a conserved threonine in C-terminal +7 layer near transmembrane domain. Mutation of threonine to isoleucine results in a structural change that resembles those found in syntaxins ascribed to the constitutive secretory pathway
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE
neuron-specific antigen HPC-1
, synaptotagmin-associated 35 kDa protein
, syntaxin 1A (brain)-like
, syntaxin 1A (brain)
, syntaxin 1 a
, syntaxin 1
, syntaxin 1A
, syntx 1