按照途径寻搜实验工具

Angiotensin-converting enzyme, or ACE, is a central component of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE inhibitors are of medical use as treatment of cardiovascular diseases...

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细胞凋亡是一个高度受控的过程,使生物体能够按照有组织的方式来处理或许不再需要的细胞。它通过特定类别的死亡受体或固有因素启动,比如 DNA 损坏。细胞凋亡主要由 caspase 蛋白酶类驱动,进一步受 Bcl-2 和抑制剂蛋白控制。此类程序化细胞死亡调节异常时常与癌症有关。

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Autophagy is the regulated, self-degradative process of the cell that disassembles unnecessary or dysfunctional components. The lysosomal pathway is evolutionarily conserved and initiates engulfment, degradation and recycling of cellular contents including long-lived proteins and organelles thus promoting cell survival.

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Cell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.

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补体系统是先天免疫系统的一部分,对提高机体免疫力、炎症、组织再生和其他生理进程起着非常重要的作用。补体激活不仅会引起病原体调理并被吞噬细胞清除...

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在任意生物中,都有多种DNA修复机制确保每个细胞核中基因信息的完整性。保持DNA完好的重要性体现在不同DNA修复途径的数量和这些过程涉及的多种蛋白。

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刺猬(Hh)因子信号级联对于很多发育过程来说是最重要的决定因素之一。靶向基因的基因产物决定了细胞干性、恢复、存活和迁移。Hh因子信号蛋白和下游因子的反常情况在癌症发展的过程中是很关键的。

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JAK-STAT信号传导在脊椎动物甚至一些其他后生动物中均高度保守。...

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磷酸化是指把磷酸基团添加到分子特异氨基酸残基上的可逆过程。从功能上看,磷酸化充当的是一个能够激活、灭活或或调节蛋白功能的简单分子开关。添加和去除磷酸基团实现了对蛋白活性空间和时间上的控制。

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微管是高动态的结构性、功能性胞内高速公路。细胞骨架这一术语使人联想到的画面是一种刚性的、不可改变的永久性结构。实际上...

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NF-kappaB (核因子活化B细胞轻链增强子)是一种同源或异源二聚体转录因子,在各种信号转导通路网络中处于中枢地位。...

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高度保守的Notch信号通路是独一无二的,因为Notch受体及其大多数相应配体(公认的DSL或Delta/Serrate/LAG-2 DSL家族成员)都是附着在细胞表面的跨膜蛋白。...

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p53是最重要的肿瘤抑制基因之一,常被称为“基因组守护者”。 在几乎所有的癌症中,都存在 p53基因或其调控回路中的一部分发生基因突变,由此可见其重要性。它通过防止由细胞应激或DNA损伤导致突变来保护基因组的稳定性。 p53通过调节细胞凋亡...

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PI3K/Akt通路在细胞稳态、神经发育、新陈代谢及其他过程中均发挥着关键作用。它调节着细胞发育的各个方面,如细胞凋亡、细胞周期进程和细胞分化。 PI3K/Akt通路的关键调节因子为Akt/PKB——一个由三种紧密相关的丝氨酸/苏氨酸-蛋白激酶组成的家族。其中Akt1/PKBα在细胞增殖和细胞代谢中扮演着重要角色。Akt2/PKBβ对葡萄糖代谢具有十分重要的意义。而Akt3/PKBγ则是Akt家族中特征最不明显的成员...

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RTKs属于膜结合型激酶,当与受体特异性配体结合时会被激活。它们构成了通过其内在酶活性触发信号级联反应的最大一类膜受体。这些信号通路的结构、活化机制和关键组分在后生动物中表现为高度保守。

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The T-Cell Receptor is a protein complex on the surface of T-cell responsible for antigen recognition. The activation induces a number of signaling cascades finally leading to the transcription of several gene products which allow the T cells to differentiate, proliferate and secrete a number of cytokines.

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Toll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.

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The unfolded protein response (UPR) is a cellular stress response activated in eukaryotic cells in response to endoplasmic reticulum (ER) stress, an accumulation of unfolded proteins in the ER lumen

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Vascular endothelial growth factors (VEGFs) constitute a sub-family of growth factors that stimulate the growth of new blood vessels. VEGFs are important signaling proteins and initiate angiogenesis via several signalling cascades.

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Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...

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Activated T Cell Proliferation

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Activation of Innate immune Response

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AMPK Signaling

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Asymmetric Protein Localization

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Brown Fat Cell Differentiation

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C21-Steroid Hormone Metabolic Process

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cAMP Metabolic Process

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Carbohydrate Homeostasis

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Caspase Cascade in Apoptosis

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Cell RedoxHomeostasis

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Cell-Cell Junction Organization

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Cellular Glucan Metabolic Process

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Cellular Response to Molecule of Bacterial Origin

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Chromatin Binding

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CXCR4-mediated Signaling Events

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Dicarboxylic Acid Transport

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DNA Replication

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Dopaminergic Neurogenesis

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EGFR Downregulation

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EGFR Signaling Pathway

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Embryonic Body Morphogenesis

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ER-Nucleus Signaling

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Fc-epsilon Receptor Signaling Pathway

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Feeding Behaviour

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G-protein mediated Events

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Glycosaminoglycan Metabolic Process

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Growth Factor Binding

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Hepatitis C

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Hormone Activity

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Hormone Transport

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Inositol Metabolic Process

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Integrin Complex

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Interaction of EGFR with phospholipase C-gamma

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Interferon-gamma Pathway

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Intracellular Steroid Hormone Receptor Signaling Pathway

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M Phase

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Maintenance of Protein Location

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Metabolism of Steroid Hormones and Vitamin D

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Methionine Biosynthetic Process

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Mitotic G1-G1/S Phases

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Monocarboxylic Acid Catabolic Process

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Myometrial Relaxation and Contraction

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Negative Regulation of Hormone Secretion

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Negative Regulation of intrinsic apoptotic Signaling

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Negative Regulation of Transporter Activity

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Neurotrophin Signaling Pathway

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

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Peptide Hormone Metabolism

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Photoperiodism

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Phototransduction

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Platelet-derived growth Factor Receptor Signaling

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Positive Regulation of Endopeptidase Activity

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Positive Regulation of fat Cell Differentiation

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Positive Regulation of Immune Effector Process

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Positive Regulation of Peptide Hormone Secretion

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Positive Regulation of Response to DNA Damage Stimulus

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Production of Molecular Mediator of Immune Response

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Protein targeting to Nucleus

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Proton Transport

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Regulation of Actin Filament Polymerization

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Regulation of Carbohydrate Metabolic Process

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Regulation of Cell Size

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Regulation of G-Protein Coupled Receptor Protein Signaling

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Regulation of Hormone Biosynthetic Process

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

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Regulation of Leukocyte Mediated Immunity

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Regulation of Lipid Metabolism by PPARalpha

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Regulation of long-term Neuronal Synaptic Plasticity

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Regulation of Muscle Cell Differentiation

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Regulation of Systemic Arterial Blood Pressure by Hormones

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Regulatory RNA Pathways

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Response to Growth Hormone Stimulus

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Response to Water Deprivation

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Retinoic Acid Receptor Signaling Pathway

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Ribonucleoprotein Complex Subunit Organization

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Ribonucleoside Biosynthetic Process

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Ribosome Assembly

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Sensory Perception of Sound

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Signaling Events mediated by VEGFR1 and VEGFR2

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Signaling of Hepatocyte Growth Factor Receptor

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Skeletal Muscle Fiber Development

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Smooth Muscle Cell Migration

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Stem Cell Maintenance

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Steroid Hormone Biosynthesis

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Steroid Hormone Mediated Signaling Pathway

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Synaptic Membrane

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Synaptic Vesicle Exocytosis

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Synthesis of DNA

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Telomere Maintenance

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Thromboxane A2 Receptor Signaling

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Thyroid Hormone Synthesis

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Toll-Like Receptors Cascades

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Transition Metal Ion Homeostasis

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Tube Formation

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VEGFR1 Specific Signals

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