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按照途径寻搜实验工具

Apoptosis

细胞凋亡是一个高度受控的过程,使生物体能够按照有组织的方式来处理或许不再需要的细胞。它通过特定类别的死亡受体或固有因素启动,比如 DNA 损坏。细胞凋亡主要由 caspase 蛋白酶类驱动,进一步受 Bcl-2 和抑制剂蛋白控制。此类程序化细胞死亡调节异常时常与癌症有关。

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Cell Division Cycle

Cell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.

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Complement System

补体系统是先天免疫系统的一部分,对提高机体免疫力、炎症、组织再生和其他生理进程起着非常重要的作用。补体激活不仅会引起病原体调理并被吞噬细胞清除...

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DNA Damage Repair

在任意生物中,都有多种DNA修复机制确保每个细胞核中基因信息的完整性。保持DNA完好的重要性体现在不同DNA修复途径的数量和这些过程涉及的多种蛋白。

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Hedgehog Signaling

刺猬(Hh)因子信号级联对于很多发育过程来说是最重要的决定因素之一。靶向基因的基因产物决定了细胞干性、恢复、存活和迁移。Hh因子信号蛋白和下游因子的反常情况在癌症发展的过程中是很关键的。

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JAK/STAT Signaling

JAK-STAT信号传导在脊椎动物甚至一些其他后生动物中均高度保守。...

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MAPK Pathway

磷酸化是指把磷酸基团添加到分子特异氨基酸残基上的可逆过程。从功能上看,磷酸化充当的是一个能够激活、灭活或或调节蛋白功能的简单分子开关。添加和去除磷酸基团实现了对蛋白活性空间和时间上的控制。

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Microtubule Dynamics

微管是高动态的结构性、功能性胞内高速公路。细胞骨架这一术语使人联想到的画面是一种刚性的、不可改变的永久性结构。实际上...

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NF-kappaB Signaling

NF-kappaB (核因子活化B细胞轻链增强子)是一种同源或异源二聚体转录因子,在各种信号转导通路网络中处于中枢地位。...

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Notch Signaling

高度保守的Notch信号通路是独一无二的,因为Notch受体及其大多数相应配体(公认的DSL或Delta/Serrate/LAG-2 DSL家族成员)都是附着在细胞表面的跨膜蛋白。...

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p53 Pathway

p53是最重要的肿瘤抑制基因之一,常被称为“基因组守护者”。 在几乎所有的癌症中,都存在 p53基因或其调控回路中的一部分发生基因突变,由此可见其重要性。它通过防止由细胞应激或DNA损伤导致突变来保护基因组的稳定性。 p53通过调节细胞凋亡...

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PI3K-Akt Signaling

PI3K/Akt通路在细胞稳态、神经发育、新陈代谢及其他过程中均发挥着关键作用。它调节着细胞发育的各个方面,如细胞凋亡、细胞周期进程和细胞分化。 PI3K/Akt通路的关键调节因子为Akt/PKB——一个由三种紧密相关的丝氨酸/苏氨酸-蛋白激酶组成的家族。其中Akt1/PKBα在细胞增殖和细胞代谢中扮演着重要角色。Akt2/PKBβ对葡萄糖代谢具有十分重要的意义。而Akt3/PKBγ则是Akt家族中特征最不明显的成员...

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RTK signaling

RTKs属于膜结合型激酶,当与受体特异性配体结合时会被激活。它们构成了通过其内在酶活性触发信号级联反应的最大一类膜受体。这些信号通路的结构、活化机制和关键组分在后生动物中表现为高度保守。

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TLR signaling

Toll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.

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WNT signaling

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...

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ACE Inhibitor Pathway

Browse our ACE inhibitor pathway related antibodies and ELISA kits.

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Activation of Innate immune Response

Browse our antibodies, ELISA kits and proteins related to the activation of innate immune response.

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AMPK Signaling

Browse our AMPK signaling pathway related antibodies and ELISA kits.

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C21-Steroid Hormone Metabolic Process

Browse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.

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Caspase Cascade in Apoptosis

Browse our Caspase cascade related antibodies and ELISA kits.

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Dopaminergic Neurogenesis

Browse our antibodies, ELISA kits and proteins related to Dopaminergic Neurogenesis.

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EGFR Signaling Pathway

Browse our EGFR signaling pathway related antibodies and ELISA kits.

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Fc-epsilon Receptor Signaling Pathway

Browse our Fc-epsilon Receptor Signaling Pathway related antibodies and ELISA kits.

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Hormone Activity

Browse our antibodies, ELISA kits and proteins related to hormone activity.

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Hormone Transport

Browse our antibodies, ELISA kits and proteins related to hormone transport.

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Interferon-gamma Pathway

Browse our IFN-gamma pathway related antibodies and ELISA kits.

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Intracellular Steroid Hormone Receptor Signaling Pathway

Browse our intracellular steroid hormone receptor signaling pathway related antibodies and ELISA kits.

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Metabolism of Steroid Hormones and Vitamin D

Browse our products related to metabolism of steroid hormones and vitamin D.

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Metabolism of Steroid Hormones and Vitamin D

Browse our antibodies, ELISA kits and proteins related to the metabolism of steroid hormones and vitamin D.

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Negative Regulation of Hormone Secretion

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Neurotrophin Signaling Pathway

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

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Peptide Hormone Metabolism

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Positive Regulation of Peptide Hormone Secretion

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Regulation of Hormone Biosynthetic Process

Browse our antibodies, ELISA kits and proteins related to the regulation of hormone biosynthetic processes.

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

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Regulation of Systemic Arterial Blood Pressure by Hormones

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Regulatory RNA Pathways

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Response to Growth Hormone Stimulus

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Retinoic Acid Receptor Signaling Pathway

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Steroid Hormone Biosynthesis

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TCR Signaling

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Telomere Maintenance

Browse our telomere maintenance related antibodies and ELISA kits.

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Thyroid Hormone Synthesis

Browse our antibodies, ELISA kits and proteins related to thyroid hormone synthesis.

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