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CD3 FITC - CD28 PE Bi-Test Reagent

FACS 适用: 人 FACS FITC,PE 宿主: 小鼠
产品编号 ABIN2763694
发货至: 中国
  • 抗原
    CD3, CD28
    适用
    宿主
    小鼠
    标记
    FITC,PE
    应用范围
    Flow Cytometry (FACS)
    品牌
    Bi-Test™
    纯化方法
    Protein A/G Chromatography
    亚型
    IgG1
  • 限制
    仅限研究用
  • 储存条件
    4 °C
  • 抗原
    CD3, CD28
    背景
    The CD3 epitope is expressed on the epsilon chain of the CD3/T cell antigen receptor (TcR) complex. CD3 is expressed on 65-85 % of thymocytes and has a mitogenic effect on peripheral blood T cells. Identification of human T cells expressing the 22-28,000 M. W. surface antigen. Antihuman CD28 binds the 44 kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 Molecule on the surface of activated B cells. B7/BB-1 co-stimulates T cells through CD28, along with CD2 and CD3. CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60 %-80 % 0flymphocytes (95 % of CD4 and 50 % of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
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