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anti-Interleukin 1 alpha (IL1A) antibody pair

ABIN1305225 产品详细信息, 供应商: Log in to see
抗原
  • Il-1
  • Il-1a
  • IL-1 alpha
  • IL-1A
  • IL1
  • IL1-ALPHA
  • IL1F1
  • IL-1alpha
  • L1A
  • interleukin 1 complex
  • interleukin 1 alpha
  • interleukin 1, alpha
  • Il1
  • Il1a
  • IL1A
适用
小鼠
宿主

克隆类型
多克隆
实验类型
Sandwich ELISA
检测范围
15.6-2000 pg/mL
最低检测浓度
15.6 pg/mL
应用范围
ELISA
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特异性 Detects mouse IL-1alpha.
无交叉反应
交叉反应 (详细) Does not detect human IL-1alpha or mouse IL-1beta.
灵敏度 10 pg/mL
组件 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μg) [COAT] 1 vial detection antibody (30μg) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
别名 IL-1alpha
背景 The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UniProt P01582
研究领域 Cytokines, Immunology, Virology, Inflammation, Cancer
限制 仅限研究用
储存条件 -20 °C
储存方法 Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
有效期 12 months