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Frame-shift mutation in TWIST1 is associated with type 2 scurs syndrome.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
Results have shown that the formation of a TWIST1- RELA (显示 NFkBP65 蛋白) complex is partially dependent on the well conserved W190, R191, and E193 residues of the TWIST1 WR domain, and that mutations at these positions reduce binding and downstream IL-8 (显示 IL8 蛋白) promoter activation.
In urothelial bladder carcinoma, TWIST1 expression positively correlated with KLF4 (显示 KLF4 蛋白). Metastasis-free survival was poorest in those with KLF4 (显示 KLF4 蛋白)/TWIST1 coexpression. KLF4 (显示 KLF4 蛋白) knockdown suppressed TWIST1 expression. KLF4 (显示 KLF4 蛋白) overexpression activated TWIST1 expression and restored EMT (显示 ITK 蛋白) and metastatic phenotype. TWIST1 knockdown abolished KLF4 (显示 KLF4 蛋白)-faciliated EMT (显示 ITK 蛋白) and metastatic feature without affecting KLF4 (显示 KLF4 蛋白) expression.
data provide the first evidence that T17M rhodopsin (显示 RHO 蛋白) mutant disrupts C3 secretion via the induction of ROS (显示 ROS1 蛋白) and the suppression of TWIST1.
C-ROS-1 (显示 ROS1 蛋白) is involved in Bone marrow-derived mesenchymal stem/stromal cell fate switching between osteogenesis and adipogenesis, mediated via PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白)/mTORC1 signalling.
Data show that twist-related protein 1 (Twist1) requires TGF-beta type-I receptor (TGFBR1 (显示 TGFBR1 蛋白))-activation for activation for epithelial-mesenchymal transition (EMT (显示 ITK 蛋白))-induction.
High Twist1 expression is associated with mesenchymal to epithelial transition of breast cancer.
FGFR2 (显示 FGFR2 蛋白), TWIST1, and FGFR3 (显示 FGFR3 蛋白) mutations were identified in children with tracheal cartilaginous sleeve (TCS). All five children with a W290C mutation in FGFR2 (显示 FGFR2 蛋白) had TCS, and most previously reported children with W290C had identification of TCS or early death
Data show that miR (显示 MLXIP 蛋白)-26b-5p suppresses Twist1-induced EMT (显示 ITK 蛋白), invasion, and metastasis of HCC (显示 FAM126A 蛋白) cells by targeting SMAD1 (显示 GARS 蛋白).
DNMT3 mutation in OCI-AML3 (显示 RUNX2 蛋白) strain enhances leukemic aggressiveness by promoting extramedullary infiltration process, which is partially through upregulating TWIST1.
By analyzing the expression levels of miR (显示 MLXIP 蛋白)-497, Twist was found inversely correlated with miR (显示 MLXIP 蛋白)-497 in pancreatic cancer tissues, and a positive correlation was found between Twist and VEGFA (显示 VEGFA 蛋白) levels in pancreatic cancer specimens
molecular and cellular processes that regulate dural Cerebral vein development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models, are reported.
Methyltransferase G9A (显示 EHMT2 蛋白) Regulates Osteogenesis via Twist Gene Repression in mice.
this study shows that loss of Twist1 in collagen-producing cells leads to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12 (显示 CXCL12 蛋白)
RNF8 (显示 RNF8 蛋白)-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
These results indicate that Twist1 Ser42 phosphorylation contributes to the pathogenesis of bleomycin-induced pulmonary fibrosis through angiopoietin-Tie2 (显示 TEK 蛋白) signaling.
the mesenchymal properties of the cranial mesoderm are likely to be regulated by a network of TWIST1 targets that influences the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures.
TWIST1 expression promotes developmental angiogenesis by inducing endothelial cell proliferation and migration.
There was a possible regulatory link between Twist 1 and PPARgamma (显示 PPARG 蛋白) in 3T3-L1 mature adipocytes. This regulatory link enhanced the regulation of PPARgamma (显示 PPARG 蛋白) and may be a functional mechanism of Twist 1 regulation of adipocyte physiology and pathology
ur study revealed the dynamic Twist localization within the early stage of embryo. The results are discussed in terms of potential roles of Twist1 in the processes of lineage segregation, hatching, and implantation in post-compaction embryos and in blastocysts.
findings demonstrate that Twist-1, which maintains BMSC at an immature state, endows them with an increased capacity for supporting hematopoiesis via direct activation of CXCL12 (显示 CXCL12 蛋白) gene expression.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
twist1a and twist1b control skeletal development and dorsoventral patterning by regulating runx2b in zebrafish
These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue\; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
twist homolog 1
, twist transcription factor
, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
, hypothetical protein
, twist-like protein
, twist-related protein 1
, twist-related protein
, B-HLH DNA binding protein
, TWIST homolog of drosophila
, class A basic helix-loop-helix protein 38
, charlie chaplin
, polydactyly EMS
, twist gene homolog 1
, twist 1
, twist homolog 1 (Drosophila)