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Frame-shift mutation in TWIST1 is associated with type 2 scurs syndrome.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
our results demonstrate that Twist over-expression is a statistically significant indicator of OS in breast cancer. In addition, our meta-analysis shows that increased Twist expression is significantly associated with larger tumor size, lymph node involvement, higher nuclear grade, and positive HER2 (显示 ERBB2 蛋白) status.
TWIST elicits resistance to paclitaxel via the regulation of the Akt (显示 AKT1 蛋白) and Bcl-2 (显示 BCL2 蛋白) pathway
Increased expression of twist/podoplanin (显示 PDPN 蛋白) in ductal breast carcinoma was associated with shorter patient survival.
we demonstrate how COL11A1 regulates twist family basic helix-loop-helix transcription factor (显示 HEY1 蛋白) 1 (显示 HNF1A 蛋白)-related protein 1 (TWIST1) to induce chemoresistance and inhibit apoptosis in ovarian cancer cells
We suggest that APA (显示 ENPEP 蛋白) enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner
the entire cohort of VEGF (显示 VEGFA 蛋白)(+) /TWIST1(-) patients showed a statistically worse DFS (显示 FST 蛋白) than the patients with VEGF (显示 VEGFA 蛋白)(-) /TWIST1(+) expression (p = 0.034). In conclusion, we found that tumour stratification based on an immunoprofile is useful to predict the patient clinical behaviour.
Low TWIST1 expression is associated with renal cell carcinoma (显示 MOK 蛋白).
SPZ1 (显示 SPZ1 蛋白) promotes epithelial-mesenchymal transition (EMT (显示 ITK 蛋白))transition by trans-activating the gene of TWIST1. A clinical analysis showed a marker association of SPZ1 (显示 SPZ1 蛋白) and TWIST1 with induction of tumorigenesis in HCC (显示 FAM126A 蛋白) patients.
TrpC5 (显示 TRPC5 蛋白) induces the epithelial-mesenchymal transition through the HIF-1alpha (显示 HIF1A 蛋白)-Twist signaling pathway to promote tumor metastasis in colon cancer.
molecular and cellular processes that regulate dural Cerebral vein development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models, are reported.
Methyltransferase G9A (显示 EHMT2 蛋白) Regulates Osteogenesis via Twist Gene Repression in mice.
this study shows that loss of Twist1 in collagen-producing cells leads to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12 (显示 CXCL12 蛋白)
RNF8 (显示 RNF8 蛋白)-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
These results indicate that Twist1 Ser42 phosphorylation contributes to the pathogenesis of bleomycin-induced pulmonary fibrosis through angiopoietin-Tie2 (显示 TEK 蛋白) signaling.
the mesenchymal properties of the cranial mesoderm are likely to be regulated by a network of TWIST1 targets that influences the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures.
TWIST1 expression promotes developmental angiogenesis by inducing endothelial cell proliferation and migration.
There was a possible regulatory link between Twist 1 and PPARgamma (显示 PPARG 蛋白) in 3T3-L1 mature adipocytes. This regulatory link enhanced the regulation of PPARgamma (显示 PPARG 蛋白) and may be a functional mechanism of Twist 1 regulation of adipocyte physiology and pathology
ur study revealed the dynamic Twist localization within the early stage of embryo. The results are discussed in terms of potential roles of Twist1 in the processes of lineage segregation, hatching, and implantation in post-compaction embryos and in blastocysts.
findings demonstrate that Twist-1, which maintains BMSC at an immature state, endows them with an increased capacity for supporting hematopoiesis via direct activation of CXCL12 (显示 CXCL12 蛋白) gene expression.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
twist1a and twist1b control skeletal development and dorsoventral patterning by regulating runx2b in zebrafish
These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue\; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
twist homolog 1
, twist transcription factor
, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
, hypothetical protein
, twist-like protein
, twist-related protein 1
, twist-related protein
, B-HLH DNA binding protein
, TWIST homolog of drosophila
, class A basic helix-loop-helix protein 38
, charlie chaplin
, polydactyly EMS
, twist gene homolog 1
, twist 1
, twist homolog 1 (Drosophila)