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This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM (显示 ATM ELISA试剂盒)-dependent breast cancer suppression.
Upregulation of TRIM29 is associated with thyroid cancer.
miR (显示 MLXIP ELISA试剂盒)-761 acts as an oncogene (显示 RAB1A ELISA试剂盒) in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29.
Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC (显示 CALR ELISA试剂盒) cells.
Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target.
define a novel function for ATDC in the RNF8 (显示 RNF8 ELISA试剂盒)-mediated DNA damage response and implicate RNF8 (显示 RNF8 ELISA试剂盒) binding as a key determinant of the radioprotective function of ATDC
Results suggest that TRIM29 functions as an oncogene (显示 RAB1A ELISA试剂盒) in gastric cancer and is regulated by miR (显示 MLXIP ELISA试剂盒)-185.
TRIM29 functions as a scaffold protein (显示 HOMER1 ELISA试剂盒) to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response.
These findings suggest that TRIM29 regulates the p63 (显示 RPE65 ELISA试剂盒)-mediated pathway and the behavior of cervical cancer cells.
Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells.
this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages
ATDC up-regulates CD44 (显示 CD44 ELISA试剂盒) in mouse and human PanIN lesions via activation of beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT (显示 ITK ELISA试剂盒)) phenotype characterized by expression of Zeb1 (显示 ZEB1 ELISA试剂盒) and Snail1 (显示 SNAI1 ELISA试剂盒).
Histone deacetylase 9 (HDAC9 (显示 HDAC9 ELISA试剂盒)) regulates the functions of the ATDC (TRIM29) protein
ATDC increases cell proliferation via inhibition of p53 (显示 TP53 ELISA试剂盒) nuclear activities.
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
ataxia telangiectasia group D-associated protein
, ataxia-telangiectasia group D-associated protein
, tripartite motif protein TRIM29
, tripartite motif-containing 29
, tripartite motif-containing protein 29
, tripartite motif protein 29
, tripartite motif-containing protein 29-like