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After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (显示 FUT1 ELISA试剂盒)) cycling and induces p53 (显示 TP53 ELISA试剂盒)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (显示 FUT1 ELISA试剂盒) self-renewal and accumulation of DNA damage in p53 (显示 TP53 ELISA试剂盒) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (显示 TP53BP2 ELISA试剂盒) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (显示 TP53 ELISA试剂盒)-independent manner.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (显示 TP53 ELISA试剂盒) and ASPP1 and downregulation of iASPP (显示 PPP1R13L ELISA试剂盒).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein (显示 LAT ELISA试剂盒) C (显示 PROC ELISA试剂盒)-Nap1 (显示 CEP250 ELISA试剂盒). Co-depletion of ASPP1 and ASPP2 (显示 TP53BP2 ELISA试剂盒) inhibited re-association of C-Nap1 (显示 CEP250 ELISA试剂盒) with centrosome at the end of mitosis.
ASPP1 and ASPP2 (显示 TP53BP2 ELISA试剂盒) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (显示 TP53 ELISA试剂盒).
When the Px(T)PxR (显示 NR1I2 ELISA试剂盒) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (显示 TP53BP2 ELISA试剂盒) and iASPP (显示 PPP1R13L ELISA试剂盒).
the mRNA expression of ASPP1 and ASPP2 (显示 TP53BP2 ELISA试剂盒) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (显示 TP53 ELISA试剂盒)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (显示 YAP1 ELISA试剂盒) results in the decreased expression of LATS2, which lowers the ability of p53 (显示 TP53 ELISA试剂盒) to induce p21 (显示 CDKN1A ELISA试剂盒), cell-cycle arrest and senescence.
overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F (显示 E2F1 ELISA试剂盒) pathway
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
protein phosphatase type 2C alpha 1
, protein phosphatase 1, regulatory (inhibitor) subunit 13B
, apoptosis-stimulating protein of p53, 1
, apoptosis-stimulating of p53 protein 1-like
, apoptosis-stimulating of p53 protein 1
, protein phosphatase 1 regulatory subunit 13B
, transformation related protein 53 binding protein 2
, tumor protein p53 binding protein, 2
, tumor protein p53-binding protein, 2
, apoptosis-stimulating protein of p53