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Therefore, the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Data show that Noxa-mediated MCL-1 (显示 MCL1 ELISA试剂盒) phosphorylation and degradation is regulated by CDK2 (显示 CDK2 ELISA试剂盒).
the c-FLIP (显示 CFLAR ELISA试剂盒) and NOXA/Mcl-1 (显示 MCL1 ELISA试剂盒) axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
Noxa is involved in X-ray-induced lung injury.
Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs.
knockdown of MCL-1 (显示 MCL1 ELISA试剂盒) in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells
high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression
Inhibition of SIRT1 (显示 SIRT1 ELISA试剂盒) could induce the Noxa expression in A549/DDP (显示 TIMM8A ELISA试剂盒) cells.
Fluorizoline bind to prohibitin (显示 PHB ELISA试剂盒), inducing mitochondrial apoptotic pathway through NOXA and BIM (显示 BCL2L11 ELISA试剂盒) upregulation.
Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma
SATB1 (显示 SATB1 ELISA试剂盒) as a Dual Regulator of Anti-Apoptotic BCL2 (显示 BCL2 ELISA试剂盒) and Pro-Apoptotic NOXA Genes
knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.
In vivo upregulation of noxa was reduced by pifithrin-alpha, suggesting transcription may be partly p53 (显示 TP53 ELISA试剂盒)-dependent.The present findings indicate Noxa does not serve as a proapoptotic BH3-only protein (显示 BAD ELISA试剂盒) during seizure-induced neuronal death in vivo
In addition, studies in leukemia Jurkat T cells support the existence of the Sall2 (显示 SALL2 ELISA试剂盒)/Noxa axis, and the significance of this axis on the apoptotic response to doxorubicin in cancer cells.
Our data demonstrate that ES cells are uniquely sensitive to CDK1 (显示 CDK1 ELISA试剂盒) inhibition via a p53 (显示 TP53 ELISA试剂盒)/NOXA/MCL1 (显示 MCL1 ELISA试剂盒) pathway.
Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress.
by preventing the consumption of IL-15 (显示 IL15 ELISA试剂盒), Bim (显示 BCL2L11 ELISA试剂盒) limits the role of Noxa and Puma (显示 BBC3 ELISA试剂盒) in causing the death of effector cells with less memory potential.
Induction of noxa does not influence ischemic neuronal injury.
the current findings indicate that Noxa is a novel regulator of early mitosis before 75% epiboly stage when it translates into a key mediator of apoptosis in subsequent embryogenesis.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
phorbol-12-myristate-13-acetate-induced protein 1
, PMA-induced protein 1
, adult T cell leukemia-derived PMA-responsive
, immediate-early-response protein APR
, protein Noxa