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MDM2 抗体

(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008].
MDM2 抗体  (Center) MDM2 抗体  (Center) MDM2 抗体 (Center) (ABIN2854782)

MDM2 适用: 人, 小鼠 WB, IF, IHC (p), IP, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

MDM2 抗体  (AA 101-200) MDM2 抗体  (AA 101-200) MDM2 抗体 (AA 101-200) (ABIN517806)

MDM2 适用: 人 WB, ELISA, IHC (p), RNAi, PLA 宿主: 小鼠 Monoclonal 1A7 unconjugated

MDM2 抗体  (pSer166) MDM2 抗体  (pSer166) MDM2 抗体 (pSer166) (ABIN6256167)

MDM2 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

MDM2 抗体 by Grade

Find MDM2 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

MDM2 抗体 by 适用

Find MDM2 抗体 for a variety of species such as anti-Human MDM2, anti-Mouse MDM2, anti-Rat MDM2. The species listed below are among those available. Click on a link to go to the corresponding products.

MDM2 抗体 by 应用范围

Find MDM2 抗体 validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

MDM2 抗体 by 抗体来源

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MDM2 抗体 by 抗原表位

Find MDM2 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MDM2 抗体 by 克隆形成能力

Find available monoclonal or polyclonal MDM2 抗体. Click on a link to go to the corresponding products.

MDM2 抗体 by 克隆

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MDM2 抗体 by 标记

Find MDM2 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MDM2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IF, IHC (p), IP, ICC, ChIP
Validations
  • (7)
Cat. No. ABIN2854782
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), RNAi, PLA
Validations
  • (6)
Cat. No. ABIN517806
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Monkey, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (5)
Cat. No. ABIN6256167
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS
Validations
  • (5)
Cat. No. ABIN7193584
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (7)
Cat. No. ABIN3031739
Quantity 0.2 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro)
Validations
  • (4)
Cat. No. ABIN802548
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7007153
Quantity 60 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IHC, IF, IP, ICC
Validations
  • (4)
Cat. No. ABIN6263177
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (4)
Cat. No. ABIN1490872
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6143671
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (4)
Cat. No. ABIN7193592
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), FACS
Validations
  • (2)
  • (4)
Cat. No. ABIN388067
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (5)
Cat. No. ABIN3031734
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF (p), IF (cc), ICC, FACS, IHC (fro)
Validations
  • (3)
Cat. No. ABIN802533
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7138447
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our MDM2 抗体

Duan, Ma, Huang, DAmore, Zhang, Lei et al.: "The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and ..." in: The Journal of biological chemistry, Vol. 291, Issue 31, pp. 16339-47, (2017) (PubMed).

Fragou, Tzimagiorgis, Karageorgopoulos, Barbetakis, Lazopoulos, Papaioannou, Haitoglou, Kouidou: "Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 1455-1460, (2017) (PubMed).

Zhou, Duan, Ma, Wu, Hu, Chen, Chee, Cui, Samad, Matsubara, Mukai, DAmore, Lei: "Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy." in: Investigative ophthalmology & visual science, Vol. 58, Issue 12, pp. 5361-5367, (2017) (PubMed).

Mokhtarzadeh, Parhiz, Hashemi, Abnous, Ramezani: "P53-Derived peptides conjugation to PEI: an approach to producing versatile and highly efficient targeted gene delivery carriers into cancer cells." in: Expert opinion on drug delivery, Vol. 13, Issue 4, pp. 477-91, (2016) (PubMed).

Guo, Yang, Yang, Linghu, Zhan, Brock, Herman, Zhang, Guo: "RASSF10 suppresses colorectal cancer growth by activating P53 signaling and sensitizes colorectal cancer cell to docetaxel." in: Oncotarget, Vol. 6, Issue 6, pp. 4202-13, (2015) (PubMed).

Xiao, Zhou, Yi, Luo, Jiang, Tian, Li, Xue: "Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro." in: International journal of oncology, Vol. 46, Issue 4, pp. 1677-84, (2015) (PubMed).

Li, Liu, Wang, Fang, Shen, Cai, Gao, Li, Zhang, Ye: "The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22649-61, (2015) (PubMed).

Liao, Xiao, Zhu, Zheng, He, Pei, Li, Zhou: "CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer." in: Oncology reports, Vol. 32, Issue 6, pp. 2703-9, (2014) (PubMed).

Khoronenkova, Dianova, Parsons, Dianov: "USP7/HAUSP stimulates repair of oxidative DNA lesions." in: Nucleic acids research, Vol. 39, Issue 7, pp. 2604-9, (2011) (PubMed).

Lei, Velez, Kazlauskas: "Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53." in: Molecular and cellular biology, Vol. 31, Issue 9, pp. 1788-99, (2011) (PubMed).

Aliases for MDM2 抗体

MDM2 proto-oncogene (MDM2) 抗体
MDM2 proto-oncogene S homeolog (mdm2.S) 抗体
MDM2 proto-oncogene (Mdm2) 抗体
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) 抗体
MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) 抗体
transformed mouse 3T3 cell double minute 2 (Mdm2) 抗体
1700007J15Rik 抗体
AA415488 抗体
ACTFS 抗体
hdm2 抗体
HDMX 抗体
Mdm-2 抗体
zgc:109834 抗体
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