anti-MDM2 (MDM2) 抗体产品概述

Full name:
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) 抗体 (MDM2)
在www.antibodies-online.cn可供392 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) 抗体的25不同的供货商。 再加上,我们可以发MDM2 蛋白 (21)MDM2 试剂盒 (10)和数多这个蛋白质的别的产品。 总共459 MDM2产品已列进来了。
别名:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834

所有可销售的anti-MDM2 抗体

您会转到已过滤好的搜索

引用最多的anti-MDM2 抗体

  1. Human Polyclonal MDM2 Primary Antibody for EIA - ABIN358421 : Burch, Scott, Pohler, Meek, Hupp: Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. in Journal of molecular biology 2004 (PubMed)
    Show all 5 references for 358421

  2. Human Polyclonal MDM2 Primary Antibody for EIA, IHC (p) - ABIN356776 : Schon, Friedler, Freund, Fersht: Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. in Journal of molecular biology 2004 (PubMed)
    Show all 5 references for 356776

  3. Human Polyclonal MDM2 Primary Antibody for IHC (p), WB - ABIN388068 : Xia, Paik, Li: p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. in Cancer research 2004 (PubMed)
    Show all 3 references for 388068

  4. Human Polyclonal MDM2 Primary Antibody for DB, EIA - ABIN358505 : Balass, Kalef, Maya, Wilder, Oren, Katchalski-Katzir: Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation. in Peptides 2002 (PubMed)
    Show all 3 references for 358505

  5. Human Monoclonal MDM2 Primary Antibody for IHC (fro), IHC (p) - ABIN180331 : Gueven, Becherel, Birrell, Chen, DelSal, Carney, Grattan-Smith, Lavin: Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. in Cancer research 2006 (PubMed)
    Show all 3 references for 180331

  6. Human Polyclonal MDM2 Primary Antibody for IF, IHC (p) - ABIN388067 : Lei, Velez, Kazlauskas: Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. in Molecular and cellular biology 2011 (PubMed)
    Show all 2 references for 388067

  7. Human Monoclonal MDM2 Primary Antibody for BI, IHC (f) - ABIN967511 : Martin, Trouche, Hagemeier, Sørensen, La Thangue, Kouzarides: Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. in Nature 1995 (PubMed)
    Show all 2 references for 967511

  8. Human Polyclonal MDM2 Primary Antibody for ELISA, WB - ABIN185508 : Bond, Hu, Bond, Robins, Lutzker, Arva, Bargonetti, Bartel, Taubert, Wuerl, Onel, Yip, Hwang, Strong, Lozano, Levine: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. in Cell 2004 (PubMed)

更多抗MDM2的相互作用对抗体

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. a novel molecular mechanism which, in silico, is capable of triggering p53 (显示 TP53 抗体) oscillations. The mechanism that is based on Mdm2's dual regulation of p53 (显示 TP53 抗体) can provide mechanistic insights into an excitability of the p53 (显示 TP53 抗体) network, thus it contributes to understanding of variability of p53 (显示 TP53 抗体) dynamics in response to single and double strand breaks.

  2. Histologically low-grade and relatively low-grade cases of extraskeletal osteosarcoma are not always associated with MDM2 amplification. ESOS cases with MDM2 amplification could be high grade.

  3. Disturbed p53 (显示 TP53 抗体)-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 (显示 TRIM25 抗体) overexpression.

  4. These results identify a novel function for FKBP12 (显示 FKBP1A PLURAL_@30317@) in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.

  5. Although uncommon, MDM2 labeling is seen in a subset of fat-predominant angiolipomas and is a potential diagnostic pitfall in the evaluation of fatty tumors of the retroperitoneum.

  6. high-level MDM2 expression is needed in order to perform a critical p53 (显示 TP53 抗体)-independent function and may obviate the need for genomic alterations to the p53 (显示 TP53 抗体) pathway during retinoblastoma tumorigenesis.

  7. p16 (显示 CDKN2A 抗体) in combination with MDM2 and CDK4 (显示 CDK4 抗体) immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  8. MDM2 gene single nucleotide polymorphism are associated with apoptotic signaling and smoking-related emphysematous changes in lungs.

  9. we determined the molecular mechanism responsible for IER3 (显示 IER3 抗体) degradation, involving a ternary complex of IER3 (显示 IER3 抗体), MDM2 and FHL2 (显示 FHL2 抗体), which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 (显示 FHL2 抗体) serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein

  10. NPM1 (显示 NPM1 抗体) downregulation by P-STAT5 (显示 STAT5A 抗体) is mediated by impairing the BRCA1-BARD1 (显示 BARD1 抗体) ubiquitin ligase, which controls the stability of NPM1 (显示 NPM1 抗体). In turn, decreased NPM1 (显示 NPM1 抗体) levels led to suppression of p53 (显示 TP53 抗体) expression, resulting in enhanced cell survival.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (显示 TP53 抗体)-dependent apoptosis of Theileria parva (显示 PARVA 抗体)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (显示 PARVA 抗体), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (显示 PARVA 抗体)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (显示 MDM4 抗体) caused dramatic accumulation of mutant p53 protein (显示 TP53 抗体).

  2. Together with p53 (显示 TP53 抗体), provides an experimental model for characterizing drugs and genes that affect p53 (显示 TP53 抗体) signaling.

  3. Data show that liver-specific expression of p53 (显示 TP53 抗体)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. In Fmr1 (显示 FMR1 抗体) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (显示 MEF2C 抗体) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (显示 TSFM 抗体) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (显示 FMR1 抗体) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (显示 DLG4 抗体) ubiquitination, degradation and synapse elimination in Fmr1 (显示 FMR1 抗体) KO neurons.

  2. MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (显示 TP53 抗体) overexpression-related cell death.

  3. The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.

  4. MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (显示 TP53 抗体)-independent pathway dependant on Notch1 (显示 NOTCH1 抗体) ubiquitination and proteasome degradation.

  5. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (显示 TP53 抗体)/Mdm2-Mdm4 (显示 MDM4 抗体) via a RING domain-mediated biochemical mechanism.

  6. both MDM2 and MDMX (显示 MDM4 抗体) deletion-caused pancreatic defects are completely rescued by loss of p53 (显示 TP53 抗体), verifying the crucial role of the MDM2 and/or MDMX (显示 MDM4 抗体) in regulating p53 (显示 TP53 抗体) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  7. Vif (显示 BTG1 抗体) stabilization by CBFbeta (显示 CBFB 抗体) is mainly caused by impairing MDM2-mediated degradation.

  8. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  9. we failed to detect any increase in p53 (显示 TP53 抗体) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (显示 TP53 抗体)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (显示 MDM4 抗体), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  10. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (显示 TP53 抗体).

MDM2 抗原简介

Antigen Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) 抗体
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) 抗体
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2) 抗体
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) 抗体
  • p53 E3 ubiquitin protein ligase (Mdm2) 抗体
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) 抗体
  • transformed mouse 3T3 cell double minute 2 (Mdm2) 抗体
  • 1700007J15Rik 抗体
  • AA415488 抗体
  • ACTFS 抗体
  • hdm2 抗体
  • HDMX 抗体
  • Mdm-2 抗体
  • zgc:109834 抗体

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPECIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
anti-MDM2 (MDM2) 抗体 精选生产商
您还需要查找其他产品吗?