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These results uncover p300 (显示 EP300 ELISA试剂盒) as a direct target of mTORC1 and suggest that the mTORC1-p300 (显示 EP300 ELISA试剂盒) pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
TNF-alpha (显示 TNF ELISA试剂盒) and LPS (显示 IRF6 ELISA试剂盒) promoted the interaction between MKL1 (显示 MKL1 ELISA试剂盒) and PCAF.
PCAF is a novel modulator of autophagy in hepatocellular carcinoma.
a mechanism of transcriptional regulation mediated by p27 (显示 PAK2 ELISA试剂盒), Pax5 (显示 PAX5 ELISA试剂盒), and PCAF
The studies identify a P/CAF-PAX3 (显示 PAX3 ELISA试剂盒)-FOXO1 (显示 FOXO1 ELISA试剂盒) signalling node that promotes oncogenesis and may contribute to MyoD (显示 MYOD1 ELISA试剂盒) dysfunction in Alveolar rhabdomyosarcoma (ARMS).
results strongly support our hypothesis that PCAF is induced and activated by ATRA, and the subsequent acetylation of PCAF substrates promotes granulocytic differentiation in leukemia cells
Our findings demonstrated a novel epigenetic mechanism of IL-10 (显示 IL10 ELISA试剂盒) dysregulation in inflammatory bowel disease. Down-regulation of KAT2B may disrupt the innate and adaptive inflammatory responses due to the suppression of this crucial anti-inflammatory cytokine.
Acetyltransferase p300/CBP-associated factor (PCAF) interacts with and acetylates HOXB9 (显示 HOXB9 ELISA试剂盒) both in vivo and in vitro.
Results suggest that increase in nuclear expression of p300 (显示 EP300 ELISA试剂盒), as well as the presence of cytoplasmic but loss of nuclear expression of p300/CBP-associated factor (PCAF), could play an important role in the development and progression of cutaneous squamous cell carcinomas (SCC (显示 CYP11A1 ELISA试剂盒)).
Loss of p300 (显示 EP300 ELISA试剂盒) reduced repair of mismatches in DNA mismatch repair-deficient cells, but did not have evident effects on Base Excision Repair (BER) mechanisms, including the long patch BER pathway.
These results uncover p300 (显示 NOTCH1 ELISA试剂盒) as a direct target of mTORC1 and suggest that the mTORC1-p300 (显示 NOTCH1 ELISA试剂盒) pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 (显示 NOTCH1 ELISA试剂盒) and PCAF to the NKX2.5 (显示 NKX2-5 ELISA试剂盒), beta-MHC (显示 MYH7 ELISA试剂盒), Cx43 (显示 GJA1 ELISA试剂盒) promoters and attenuated H3K9 hyperacetylation.
Gcn5 (显示 KAT2A ELISA试剂盒) and PCAF repress IFN-beta (显示 IFNB1 ELISA试剂盒) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (显示 TBK1 ELISA试剂盒) in the cytoplasm.
PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha (显示 PPARGC1A ELISA试剂盒). PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin (显示 INS ELISA试剂盒) sensitivity.
Study reveals that Gcn5 (显示 KAT2A ELISA试剂盒)/PCAF facilitate adipogenesis through regulation of PPARgamma (显示 PPARG ELISA试剂盒) expression and regulate brown adipogenesis by influencing Prdm16 (显示 PRDM16 ELISA试剂盒) expression.
KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 (显示 FOXP3 ELISA试剂盒) via Sin3-HDAC (显示 HDAC3 ELISA试剂盒)/PCAF pathway and, thus, immune activation.
PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury.
These data unveil a p53 (显示 TP53 ELISA试剂盒)/PCAF/Gli1 (显示 GLI1 ELISA试剂盒) circuitry centered on PCAF that limits Gli1 (显示 GLI1 ELISA试剂盒)-enhanced mitogenic and prosurvival response.
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
, histone acetyltransferase KAT2B
, CREBBP-associated factor
, histone acetylase PCAF
, histone acetyltransferase PCAF
, lysine acetyltransferase 2B
, K(lysine) acetyltransferase 2B