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specific alternate transcripts of activator E2F (显示 E2F2 ELISA试剂盒), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (显示 MYLIP ELISA试剂盒)-998 operates by repressing dCbl, a negative regulator of EGFR (显示 EGFR ELISA试剂盒) signaling. Significantly, dCbl is a critical target of miR (显示 MYLIP ELISA试剂盒)-998 since dCbl phenocopies the effects of miR (显示 MYLIP ELISA试剂盒)-998 on dE2f1-dependent apoptosis in rbf (显示 ATP5I ELISA试剂盒) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA by DREF in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (显示 CCNE1 ELISA试剂盒) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
Results demonstrated that E2F-1 mediated PEG10 (显示 PEG10 ELISA试剂盒) overexpression promotes pancreatic cancer cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK (显示 EPHB2 ELISA试剂盒)/MMP7 (显示 MMP7 ELISA试剂盒) pathway.
We conclude that high expression of S18 (显示 RPS18 ELISA试剂盒)-2 and free E2F...1might be a good set of prognostic markers for endometrial cancer
COMMD9 participates in TFDP1 (显示 TFDP1 ELISA试剂盒)/E2F1 activation and plays a critical role in non-small cell lung cancer.
Using iterative experimental and computational analyses, the authors show physical and functional interactions between NF-kappaB (显示 NFKB1 ELISA试剂盒) and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4 (显示 E2F4 ELISA试剂盒)) cell cycle regulators.
Heavy ion irradiation could induce p53 (显示 TP53 ELISA试剂盒)(-/-) hepatoma cells to undergo apoptosis via E2F1/Bax (显示 BAX ELISA试剂盒)/Casp3 (显示 CASP3 ELISA试剂盒) signaling pathway.
Propose that E2F1 interacts with BRCA1 indirect pathway to induce two different small molecule metabolic pathways or cell cycle regulation pathways in hepatocellular carcinoma.
The pyruvate dehydrogenase (显示 PDP ELISA试剂盒) kinases (PDKs) PDK1 (显示 PDK1 ELISA试剂盒) and PDK3 (显示 PDK3 ELISA试剂盒) are direct targets of KDM4A (显示 KDM4A ELISA试剂盒) and E2F1 and modulate the switch between glycolytic metabolism and mitochondrial oxidation.
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (显示 GSK3b ELISA试剂盒)/E2F1 axis-upregulated LSH (显示 HELLS ELISA试剂盒) promoted gliomas.
High E2F1 expression is associated with melanoma.
p63alpha protein up-regulates heat shock protein 70 (显示 HSP70 ELISA试剂盒) expression via E2F1 transcription factor 1 (显示 HNF1A ELISA试剂盒), promoting Wasf3/Wave3 (显示 WASF3 ELISA试剂盒)/MMP9 (显示 MMP9 ELISA试剂盒) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (显示 EZH2 ELISA试剂盒) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (显示 VEGFA ELISA试剂盒) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (显示 PGR ELISA试剂盒)-E2F and p27 (显示 CDKN1B ELISA试剂盒)-CDK (显示 CDK4 ELISA试剂盒) regulation, is reported.
TERT (显示 TERT ELISA试剂盒) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (显示 PDK4 ELISA试剂盒) activity in Hepatocellular carcinoma cells increased cyclin E1 (显示 CCNE1 ELISA试剂盒), cyclin A2 (显示 CCNA2 ELISA试剂盒), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (显示 ENTPD1 ELISA试剂盒) and CD73 via E2F-1 and CREB (显示 CREB1 ELISA试剂盒).
Expression of Kv10.1 (显示 KCNG3 ELISA试剂盒) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (显示 SIM2 ELISA试剂盒) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor