CHEK1 蛋白 (CHEK1)产品概述

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Checkpoint Kinase 1 蛋白 (CHEK1)
在www.antibodies-online.cn可供21 Checkpoint Kinase 1 (CHEK1) 蛋白的10不同的供货商。 再加上,我们可以发CHEK1 抗体 (488)CHEK1 试剂盒 (26)和数多这个蛋白质的别的产品。 总共575 CHEK1产品已列进来了。
别名:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
列出全部蛋白 基因 基因ID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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引用最多的CHEK1 蛋白

  1. Human CHEK1 Protein expressed in Baculovirus infected Insect Cells - ABIN457519 : Larsen, Rampalli, Burns, Brunette, Dilworth, Megeney: Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

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Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The findings reveal ATXN3 (显示 ATXN3 蛋白) to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance.

  2. Small molecule ATR (显示 ANTXR1 蛋白) and Chk1 inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  3. These findings demonstrate an unsuspected requirement for a balanced nucleotide pool for optimal Chk1 activation both in unchallenged cells and in response to genotoxic stress.

  4. ATR (显示 ANTXR1 蛋白) inhibition potentiated Chk1 inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (显示 ANTXR1 蛋白)-dependent feedback activation of Chk1 induced by Chk1 inhibitor generated replication stress in tumor cell lines.

  5. CHK1 overexpression is associated with T-cell and Hodgkin Lymphoma.

  6. Date show that when Wee1 (显示 WEE1 蛋白) alone is inhibited, Chk1 suppresses CDC45 (显示 CDC45 蛋白) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (显示 CDK4 蛋白)-activity.

  7. HPV31 regulates RRM2 (显示 RRM2 蛋白) levels through expression of E7 and activation of the ATR (显示 ANTXR1 蛋白)-Chk1-E2F1 (显示 E2F1 蛋白) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  8. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  9. revealed more than 170 NFAT (显示 NFATC1 蛋白)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (显示 NFATC1 蛋白) and NFATc2 (显示 NFAT1 蛋白) in T cells, such as Raptor (显示 RPTOR 蛋白), CHEK1, CREB1 (显示 CREB1 蛋白), RUNX1 (显示 RUNX1 蛋白), SATB1 (显示 SATB1 蛋白), Ikaros (显示 IKZF1 蛋白), and Helios (显示 ZNFN1A2 蛋白).

  10. Checkpoint kinase 1 and 2 signaling is important for apoptin regulation.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (显示 CDC45 蛋白) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (显示 DCLRE1C 蛋白) activity of Mre11 (显示 MRE11A 蛋白), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (显示 POLK 蛋白)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (显示 APEX2 蛋白) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (显示 APEX2 蛋白) is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 (显示 APEX2 蛋白) in ATR-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (显示 MAPK1 蛋白) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 蛋白) and JNK (显示 MAPK8 蛋白).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (显示 TRH 蛋白)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (显示 CDC25A 蛋白) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 蛋白)/NF-kappaB (显示 NFKB1 蛋白)-regulated apoptosis and the p53 (显示 TP53 蛋白)/PCNA (显示 PCNA 蛋白)- and ATM (显示 ATM 蛋白)/ATR-Chk1/2-controlled DNA-damage response pathways.

  2. Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan-nuclear immunostaining pattern of Histone H2AX.

  3. RAD9 (显示 RAD9A 蛋白) has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  4. Acute inactivation of E4F1 (显示 E4F1 蛋白) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (显示 ROS1 蛋白) production, energy stress, and inhibition of de novo pyrimidine synthesis

  5. Altogether, our results classify E4F1 (显示 E4F1 蛋白) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  6. Heterozygous loss of Chk1 in a Wnt (显示 WNT2 蛋白)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  7. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  8. ATM (显示 ATM 蛋白) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  9. High level of phospho-Chk1 is associated with skin tumors.

  10. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (显示 NOS3 蛋白) Ser (显示 SIGLEC1 蛋白)(1179) in response to UV irradiation, which is dependent on Hsp90 (显示 HSP90 蛋白) interaction.

蛋白简介CHEK1

蛋白简介

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1)
  • serine/threonine-protein kinase chk1 (ANI_1_2436074)
  • serine/threonine-protein kinase chk1 (AOR_1_768154)
  • serine/threonine-protein kinase Chk1 (PTRG_04183)
  • serine/threonine-protein kinase chk1 (SJAG_01680)
  • serine/threonine-protein kinase chk1 (PAAG_04978)
  • serine/threonine-protein kinase chk1 (MCYG_03290)
  • serine/threonine-protein kinase chk1 (VDBG_03742)
  • checkpoint kinase 1 (chek1)
  • checkpoint kinase 1 (Chek1)
  • CHK1 checkpoint homolog (S. pombe) (chek1)
  • CHK1 checkpoint homolog (S. pombe) (CHEK1)
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A)
  • An08g10320 蛋白
  • AO090003000441 蛋白
  • C85740 蛋白
  • CHEK1 蛋白
  • Chk1 蛋白
  • id:ibd2720 蛋白
  • rad27 蛋白
  • zgc:56093 蛋白

Protein level used designations for Checkpoint Kinase 1 蛋白 (CHEK1)

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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