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Human BAX Protein expressed in Wheat germ - ABIN1346446
Kim, Kim, Park, Hwang, Kim, Lee, Kang, Um: Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. in Cellular signalling 2012
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These results suggest a role for mitochondrial p53 (显示 TP53 蛋白) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2 (显示 BCL2 蛋白).
xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis.
BoHV-5 replication apparently modulates BCL-2 (显示 BCL2 蛋白) expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
It was concluded that the Fas (显示 FAS 蛋白)-FasL (显示 FASL 蛋白) signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (显示 TDO2 蛋白) cell lymphoma/leukemia-2 associated X upregulation.
apoptosis-inducing factor (显示 AIFM1 蛋白) was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 (显示 BCL2 蛋白) protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2 (显示 BCL2 蛋白), caspase-3 (显示 CASP3 蛋白) and-7 cannot be used as a reliable apoptosis detection method.
The effect of culture conditions on expression of heat shock protein 70 (显示 HSP70 蛋白) and Bax protein in bovine blastocysts is reported.
Heavy ion irradiation could induce p53 (显示 TP53 蛋白)(-/-) hepatoma cells to undergo apoptosis via E2F1 (显示 E2F1 蛋白)/Bax/Casp3 (显示 CASP3 蛋白) signaling pathway.
Bax effects were dependent on its oligomeric state. Monomeric Bax did not affect the membrane, oligomeric Bax lowered the breakthrough force of the membrane, which in the context of pore formation, implies a lowering of the line tension at the edge of the pore.
The results strongly suggest that the direct apoptosis-activation activities of Bid (显示 BID 蛋白), Bim (显示 BCL2L11 蛋白), Puma (显示 BBC3 蛋白), and p53 (显示 TP53 蛋白) are not essential for activating Bax/Bak (显示 BAK1 蛋白) once the anti-apoptotic Bcl-2 (显示 BCL2 蛋白) proteins are neutralized.
The C-terminal helical conformation of Bax, not its primary sequence, appears to be critical for CASP8 (显示 CASP8 蛋白) recruitment and activation culminating in cell death.
An autoinhibited dimeric form of BAX regulates the cytosolic BAX activation pathway.
Although TP53 (显示 TP53 蛋白) and BAX immunoreactivity levels were associated with some clinicopathological parameters of the patients, the expression of EP300 (显示 EP300 蛋白), TP53 (显示 TP53 蛋白) and BAX did not reveal any prognostic significance in ccRCC
Cells expressing mitoCERT import ceramides into mitochondria and undergo Bax-dependent apoptosis.
Recent studies that combine experiments in yeast and in mammalian cells have shown the unexpected effect of the anti-apoptotic protein Bcl-xL (显示 BCL2L1 蛋白) on the priming of Bax. As demonstrated with the BH3-mimetic molecule ABT-737, this property of Bcl-xL (显示 BCL2L1 蛋白), and of Bcl-2 (显示 BCL2 蛋白), is crucial to elaborate about how apoptosis could be reactivated in tumoral cells.
Results support the hypothesis that the mitochondrion-specific lipid cardiolipin functions as a first contact site for Bax during its translocation to the mitochondrial outer membrane in the onset of apoptosis. In addition, dye leakage assays revealed that different oxidized phospholipids species in the mitochondrial outer membrane-mimicking vesicles can have opposing effects on Bax pore formation.
These results not only establish Bok (显示 BOK 蛋白) as a Bak (显示 BAK1 蛋白)- and Bax-independent apoptosis inducer, but also suggest a potential impact of Bok (显示 BOK 蛋白) expression in ovarian cancer therapy.
Postnatal synaptic rearrangement needed for acquisition of skilled behaviors requires the activity-dependent, non-apoptotic Bax/Bak (显示 BAK1 蛋白)-caspase (显示 CASP3 蛋白) signaling cascade. Adult Bax/Bak (显示 BAK1 蛋白) mutant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits but normal reaching and retrieval behaviors.
Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.
The polyglutamine embedded in the ER membrane was observed at the same time as Bax insertion. These results demonstrated that the ER membrane may be a target of polyglutamine, which triggers cell death through Bax.
These results suggest that Bax mediates beta-cell apoptosis in Pdx1 (显示 PDX1 蛋白)-deficient diabetes.
Bim (显示 BCL2L11 蛋白) and Puma (显示 BBC3 蛋白) overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.
This study demonstated that Bax KO mice show Hyperactivity and depression.
The influence of chronic ethanol consumption on the expression of the Bdnf (显示 BDNF 蛋白), Bax, Bcl-xL (显示 BCL2L1 蛋白), and CASP3 (显示 CASP3 蛋白) genes was studied in the brain structures of B6-1473C (C/C) and B6-1473G (G/G) mice that had been obtained on the base of the C57BL/6 strain.
These data indicate that the rapid and robust microglial activation and PIF (显示 DCD 蛋白) expression observed in situ following acute EtOH exposure is largely driven indirectly by BAX-dependent apoptotic cell death, rather than directly by the EtOH.
lipid profile in the absence of the proapoptotic proteins BAX and BAK (显示 BAK1 蛋白) in mouse embryonic fibroblasts
Bid (显示 BID 蛋白) and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
bcl-2 (显示 BCL2 蛋白) and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2 (显示 BCL2 蛋白); bax]
goat oocytes based on G6PDH (显示 G6PD 蛋白)-activity through the BCB test improves their developmental competence, increases intracellular GSH content, and affects the expression of the apoptosis-related genes9 Bax and Bcl-2 (显示 BCL2 蛋白) ).
The content of Bax protein in the cardiomyocyte cytoplasm decreased, thus indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program in a model of ventricular overload.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2 (显示 BCL2 蛋白).
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 (显示 BCL2 蛋白) and increased expression of Bax.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2-associated X protein (BAX) transcripts and protein depending on luteal stage.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
BCL2-associated X protein
, BCL2-associated protein
, apoptosis regulator BAX
, bax zeta
, BCL2-associated X protein omega
, BCL2-associated X protein transcript variant delta2
, bcl-2-like protein 4