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Human Polyclonal ATM Primary Antibody for ICC, FACS - ABIN151030
Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005
Show all 76 Pubmed References
Human Monoclonal ATM Primary Antibody for ChIP, ELISA - ABIN151775
Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004
Show all 114 Pubmed References
Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN151622
Lai, Chun, Nahas, Mitui, Gamo, Du, Gatti: Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 26 Pubmed References
Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN151772
Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008
Show all 19 Pubmed References
Human Polyclonal ATM Primary Antibody for IHC - ABIN362100
Kang, Guo, Tan, Zhao, Tang, Lu: Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. in Mutation research 2008
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Human Polyclonal ATM Primary Antibody for IP, PLA - ABIN151739
Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006
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Human Monoclonal ATM Primary Antibody for ELISA, WB - ABIN965618
ORegan, Kiely, OGara: Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes? in Gene 1990
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Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN2668604
Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009
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Human ATM Primary Antibody for IHC - ABIN965619
Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: Involvement of human MOF in ATM function. in Molecular and cellular biology 2005
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Human Polyclonal ATM Primary Antibody for IP, WB - ABIN151738
Dirlam, Spike, Macleod: Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. in Molecular and cellular biology 2007
Show all 2 Pubmed References
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (显示 TPT1 抗体) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase (显示 ATR 抗体) plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (显示 MRE11A 抗体) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 (显示 DNA2 抗体) co-localizes in foci with RPA (显示 RPA1 抗体) and is found in a complex with replication fork components And-1 and Mcm10 (显示 MCM10 抗体). Dna2 (显示 DNA2 抗体) interacts with the DSB repair and checkpoint proteins Nbs1 (显示 NLRP2 抗体) and ATM.
ATM and ATR (显示 ATR 抗体) prevent accumulation of chromosomal abnormalities by promoting Mre11 (显示 MRE11A 抗体)/Rad50 (显示 RAD50 抗体)/Nbs1 (显示 NLRP2 抗体) dependent recovery of collapsed replication forks.
ATM and ATR (显示 ATR 抗体) phosphorylate the functionally critical replication protein Mcm2 (显示 MCM2 抗体) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (显示 TOPBP1 抗体) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (显示 TOPBP1 抗体) with ATR (显示 ATR 抗体)(ATM and Rad3-related).
ATM and ATR (显示 ATR 抗体) control mitotic events in vertebrate cells by targeting CEP63 (显示 CEP63 抗体) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (显示 TOPBP1 抗体)-dependent activation of ATR (显示 ATR 抗体)-ATRIP (显示 ATRIP 抗体) in response to double-stranded DNA breaks.
The Fanconi anemia protein (显示 FANCF 抗体) FANCM (显示 FANCM 抗体) is controlled by FANCD2 (显示 FANCD2 抗体) and the ATR (显示 ATR 抗体)/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
NOTCH1 (显示 NOTCH1 抗体) inhibits activation of ATM by impairing the formation of an ATM-FOXO3a (显示 FOXO3 抗体)-KAT5 (显示 KAT5 抗体) complex.
No strong correlation was observed between ATM mutation and function. Therefore, mutation status may not be taken as an indicator of ATM function. Rather, a direct assay of the kinase activity should be used in the development of therapies.
Results show that ATM protein expression is lost in 31% of patients with breast cancer. ATM loss is frequently observed in a distinct group with more advanced-stage disease.
ATM mutation impacts on the age-related telomere length shortening and is not related to cancer risk.
although recruitment of the MRE11 (显示 MRE11A 抗体)-RAD50 (显示 RAD50 抗体)-NBS1 (显示 NBN 抗体) (MRN) DSB-sensing complex to viral genomes and activation of the ATM kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
A high frequency of chromothriptic events occurred in cases of acute lymphoblastic anemia arising in patients with ataxia telangectasia, specifically on acrocentric chromosomes, as compared with tumors from individuals with other types of DNA repair syndromes, due to the short telomeres and poor DNA repair caused by their two ATM mutations. ATM loss in other tumors also increases chromothripsis.
ASF1a (显示 ASF1A 抗体) promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 (显示 MDC1 抗体) by ATM at double-strand breaks.
ectopic expression of Gene 33 triggers DNA damage response in an ATM serine/threonine kinase (ATM)-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).
We demonstrate that, in breast cancer cells, ATM and ATG4C (显示 ATG4C 抗体) are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype.
ATM-reactive oxygen species-iNOS (显示 NOS2 抗体) axis regulates nitric oxide mediated cellular senescence.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (显示 NOS3 抗体) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (显示 HSP90 抗体)
Data show that Tp53 (显示 TP53 抗体)- and Atm-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm-deficient CLL is sensitive to PARP1 (显示 PARP1 抗体) inhibition.
Depletion of H3K9ac in embryonic stem cells by suppression of monocytic leukemia zinc finger protein (MOZ (显示 MYST3 抗体)) acetyltransferase improved ATM activation, DNA repair, diminished irradiation-induced apoptosis, and enhanced clonogenic survival.
The data demonstrate ATM is important for the maintenance of telomere homeostasis and the surveillance of telomere dysfunction during neurogenesis.
DNA damage induces a kinetochore-based ATM/ATR-independent spindle assembly checkpoint arrest.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (显示 H2AFX 抗体) formation, and failure to remove H2BK120ub inhibits ATM- and DNAPK (显示 PRKDC 抗体)-induced gammaH2AX (显示 H2AFX 抗体) formation.
ATM expression by peritoneal B cells is required to facilitate viral reactivation during long-term infection. Thus, this study defines a proviral role of B cell-specific ATM expression during chronic gammaherpesvirus infection.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 抗体)/NF-kappaB (显示 NFKB1 抗体)-regulated apoptosis and the p53 (显示 TP53 抗体)/PCNA (显示 PCNA 抗体)- and ATM/ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体)/2-controlled DNA-damage response pathways.
this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects
This study show that like ataxia telangiectasia cells, ISG15 (显示 ISG15 抗体) is elevated in Atm-deficient mouse cerebellums.
This study identifies attenuation of type I interferon (显示 IFNA 抗体) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings