anti-ATM (ATM) 抗体产品概述

Full name:
anti-Ataxia Telangiectasia Mutated 抗体 (ATM)
在www.antibodies-online.cn可供355 Ataxia Telangiectasia Mutated (ATM) 抗体的32不同的供货商。 再加上,我们可以发ATM 试剂盒 (46)ATM 蛋白 (5)和数多这个蛋白质的别的产品。 总共420 ATM产品已列进来了。
别名:
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm

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引用最多的anti-ATM 抗体

  1. Human Monoclonal ATM Primary Antibody for ChIP, ELISA - ABIN151775 : Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004 (PubMed)
    Show all 114 references for 151775

  2. Human Polyclonal ATM Primary Antibody for ICC, FACS - ABIN151030 : Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005 (PubMed)
    Show all 76 references for 151030

  3. Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN151772 : Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008 (PubMed)
    Show all 19 references for 151772

  4. Human Polyclonal ATM Primary Antibody for IF, WB - ABIN319313 : Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: Involvement of human MOF in ATM function. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for 319313

  5. Human Polyclonal ATM Primary Antibody for IHC (p) - ABIN196822 : Bernstein, Seminara, Børresen-Dale: Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002. in Breast cancer research : BCR 2002 (PubMed)
    Show all 4 references for 196822

  6. Human Polyclonal ATM Primary Antibody for IP, PLA - ABIN151739 : Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006 (PubMed)
    Show all 4 references for 151739

  7. Human Monoclonal ATM Primary Antibody for WB - ABIN1449283 : Canman, Lim, Cimprich, Taya, Tamai, Sakaguchi, Appella, Kastan, Siliciano: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 3 references for 1449283

  8. Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN2668604 : Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009 (PubMed)
    Show all 3 references for 2668604

  9. Human Polyclonal ATM Primary Antibody for EIA - ABIN358435 : Brunet, Gutiérrez-Enríquez, Torres, Bérez, Sanjosé, Galceran, Izquierdo, Menéndez, Gumà, Borràs: ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations. in Clinical genetics 2008 (PubMed)
    Show all 2 references for 358435

  10. Human Polyclonal ATM Primary Antibody for DB, IF - ABIN389888 : Tsai, Chung, Takahashi, Xu, Hu: Functional interaction between FOXO3a and ATM regulates DNA damage response. in Nature cell biology 2008 (PubMed)
    Show all 2 references for 389888

更多抗ATM的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (显示 TPT1 抗体) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase (显示 ATR 抗体) plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (显示 MRE11A 抗体) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Dna2 (显示 DNA2 抗体) co-localizes in foci with RPA (显示 RPA1 抗体) and is found in a complex with replication fork components And-1 and Mcm10 (显示 MCM10 抗体). Dna2 (显示 DNA2 抗体) interacts with the DSB repair and checkpoint proteins Nbs1 (显示 NLRP2 抗体) and ATM.

  2. ATM and ATR (显示 ATR 抗体) prevent accumulation of chromosomal abnormalities by promoting Mre11 (显示 MRE11A 抗体)/Rad50 (显示 RAD50 抗体)/Nbs1 (显示 NLRP2 抗体) dependent recovery of collapsed replication forks.

  3. ATM and ATR (显示 ATR 抗体) phosphorylate the functionally critical replication protein Mcm2 (显示 MCM2 抗体) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (显示 TOPBP1 抗体) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (显示 TOPBP1 抗体) with ATR (显示 ATR 抗体)(ATM and Rad3-related).

  6. ATM and ATR (显示 ATR 抗体) control mitotic events in vertebrate cells by targeting CEP63 (显示 CEP63 抗体) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (显示 TOPBP1 抗体)-dependent activation of ATR (显示 ATR 抗体)-ATRIP (显示 ATRIP 抗体) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein (显示 FANCF 抗体) FANCM (显示 FANCM 抗体) is controlled by FANCD2 (显示 FANCD2 抗体) and the ATR (显示 ATR 抗体)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (显示 USP14 PLURAL_@14456@) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. We report that endogenous huntingtin (显示 HTT 抗体) protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin (显示 HTT 抗体) in live cells, we show that localization of huntingtin (显示 HTT 抗体) to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein.

  2. The study showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (显示 PALB2 抗体), CHEK2 (显示 CHEK2 抗体) and ATM

  4. Taken together, the findings suggest that a protein-protein interaction between ATM and p400 (显示 EP400 抗体) ATPase (显示 DNAH8 抗体) occurs independently of DNA damage and contributes to efficient DNA damage response and repair.

  5. following reprogramming the early and late replicating genome is differentially affected by copy number variations in ATM-deficient induced pluripotent stem cells (iPSCs) relative to wild-type iPSCs.

  6. ATM mutation is associated with ataxia (显示 USP14 PLURAL_@14456@)-telangiectasia.

  7. Results provide evidence that ATM along with 53BP1 (显示 TP53BP1 抗体) is involved in breast cancer cells resistance for PARP (显示 COL11A2 抗体) inhibitor; its deficiency causes resistance in 53BP1 (显示 TP53BP1 抗体)-depleted tumor cells.

  8. WRNIP1 (显示 WRNIP1 抗体) connects PCNA (显示 PCNA 抗体) monoubiquitination with ATMIN (显示 ATMIN 抗体)/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  9. Mutant IDH1 (显示 IDH1 抗体) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (显示 FUT1 抗体) self-renewal, independent of TET2 (显示 TET2 抗体).

  10. ATM rs189037 polymorphism is associated with reduced risk of T2DM

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Ataxia (显示 USP14 PLURAL_@14456@) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. radiation-induced eNOS (显示 NOS3 抗体) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (显示 HSP90 抗体)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 抗体)/NF-kappaB (显示 NFKB1 抗体)-regulated apoptosis and the p53 (显示 TP53 抗体)/PCNA (显示 PCNA 抗体)- and ATM/ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体)/2-controlled DNA-damage response pathways.

  2. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects

  3. This study show that like ataxia (显示 USP14 抗体) telangiectasia cells, ISG15 (显示 ISG15 抗体) is elevated in Atm-deficient mouse cerebellums.

  4. This study identifies attenuation of type I interferon (显示 IFNA 抗体) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.

  5. Mutant IDH1 (显示 IDH1 抗体) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (显示 FUT1 抗体) self-renewal, independent of TET2 (显示 TET2 抗体).

  6. USP7 (显示 USP7 抗体) inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 (显示 TP53 抗体) and synergizes with chemotherapy.

  7. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53 (显示 TP53 抗体)/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (显示 CRK 抗体) in response to prolonged exposure to IR.

  8. ATM, ATR (显示 ATR 抗体) and DNA-PKcs (显示 PRKDC 抗体) have unique and essential roles during the DNA damage response in the nervous system.

  9. TRAF6 (显示 TRAF6 抗体) and H2AX (显示 H2AFX 抗体) overexpression and gammaH2AX (显示 H2AFX 抗体)-mediated HIF1alpha (显示 HIF1A 抗体) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (显示 HIF1A 抗体)-driven tumorigenesis, glycolysis and metastasis.

  10. These results reveal a new requirement for ATMIN (显示 ATMIN 抗体)-dependent ATM signaling in TP53 (显示 TP53 抗体)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

ATM 抗原简介

Antigen Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu) 抗体
  • ataxia telangiectasia mutated (atm) 抗体
  • ataxia telangiectasia mutated (ATM) 抗体
  • ataxia telangiectasia mutated (EDI_100660) 抗体
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772) 抗体
  • ataxia telangiectasia mutated (BDBG_08252) 抗体
  • ataxia telangiectasia mutated (PAAG_02532) 抗体
  • ataxia telangiectasia mutated (MCYG_05088) 抗体
  • ataxia telangiectasia mutated (VDBG_06833) 抗体
  • ataxia telangiectasia mutated (atm) (ACLA_015700) 抗体
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900) 抗体
  • ataxia telangiectasia mutated (MGYG_07634) 抗体
  • ataxia telangiectasia mutated (PGTG_14279) 抗体
  • ataxia telangiectasia mutated (Atm) 抗体
  • ataxia telangiectasia mutated (LOC100349299) 抗体
  • ataxia telangiectasia mutated homolog (human) (Atm) 抗体
  • AI256621 抗体
  • AT1 抗体
  • ATA 抗体
  • ATC 抗体
  • ATD 抗体
  • ATDC 抗体
  • ATE 抗体
  • atm 抗体
  • atm/tefu 抗体
  • C030026E19Rik 抗体
  • CG6535 抗体
  • dATM 抗体
  • Dmel\\CG6535 抗体
  • tef 抗体
  • Tefu 抗体
  • TEL1 抗体
  • TELO1 抗体
  • Xatm 抗体

Protein level used designations for ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

GENE ID SPECIES
41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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