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APAF1 (APAF1) ELISA试剂盒产品概述

Full name:
Apoptotic Peptidase Activating Factor 1 ELISA试剂盒 (APAF1)
在www.antibodies-online.cn可供43 Apoptotic Peptidase Activating Factor 1 (APAF1) ELISA试剂盒的9不同的供货商。 再加上,我们可以发APAF1 抗体 (212)APAF1 蛋白 (7)和数多这个蛋白质的别的产品。 总共270 APAF1产品已列进来了。
别名:
6230400I06Rik, anon-53Fa, APAF-1, apaf1, Apaf1l, arc, ark, CED4, CG6829, D-Apaf-1, dapaf, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, hac-1, Hac-1/Dark, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543

适于 APAF1 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis

  2. structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]

  3. ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.

  4. Daxx (显示 DAXX ELISA试剂盒)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level

Human Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. the markers Ets-1 and APAF-1 relative to p53, Ki-67 and PTEN expression in colon adenomas/polyps, were investigated.

  2. Different selenium concentrations had varying effects on BAK1 (显示 BAK1 ELISA试剂盒) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD

  3. miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (显示 TBX1 ELISA试剂盒)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.

  4. HDAC (显示 HDAC3 ELISA试剂盒) inhibitors can induce p53 (显示 TP53 ELISA试剂盒) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.

  5. Renal APAF1 expression is increased in diabetes and diabetic nephropathy.

  6. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  7. These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.

  8. The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.

  9. cytochrome c (显示 CYCS ELISA试剂盒) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly

  10. NF-kappaB (显示 NFKB1 ELISA试剂盒) response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO (显示 ZBTB33 ELISA试剂盒) and p53 (显示 TP53 ELISA试剂盒)

Mouse (Murine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death

  2. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  3. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.

  4. study demonstrates that MMP-3 (显示 MMP3 ELISA试剂盒) leads to caspase-9 (显示 CASP9 ELISA试剂盒) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

  5. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

  6. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (显示 HSP70 ELISA试剂盒)

  7. miR (显示 MLXIP ELISA试剂盒)-23a/b and miR (显示 MLXIP ELISA试剂盒)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.

  8. a role for Apaf1 at the mitochondria

  9. The Apaf-1-independent caspase (显示 CASP3 ELISA试剂盒) activation was not inhibited by Bcl-2 (显示 BCL2 ELISA试剂盒), and occurred without the release of cytochrome c (显示 CYCS ELISA试剂盒) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.

  10. These data are consistent with a model in which alterations of GH signaling and/or insulin (显示 INS ELISA试剂盒) sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes.

Pig (Porcine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (显示 BIRC2 ELISA试剂盒).

Zebrafish Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

APAF1 抗原简介

Antigen Summary

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with APAF1

  • Apaf-1-related-killer (Ark) Elisa Kit
  • apoptotic peptidase activating factor 1 (apaf1) Elisa Kit
  • apoptotic peptidase activating factor 1 (APAF1) Elisa Kit
  • apoptotic peptidase activating factor 1 (Apaf1) Elisa Kit
  • apoptotic protease activating factor 1 (apaf1) Elisa Kit
  • 6230400I06Rik Elisa Kit
  • anon-53Fa Elisa Kit
  • APAF-1 Elisa Kit
  • apaf1 Elisa Kit
  • Apaf1l Elisa Kit
  • arc Elisa Kit
  • ark Elisa Kit
  • CED4 Elisa Kit
  • CG6829 Elisa Kit
  • D-Apaf-1 Elisa Kit
  • dapaf Elisa Kit
  • dapaf-1 Elisa Kit
  • dApaf-1/DARK/HAC-1 Elisa Kit
  • Dapaf-1/HAC-1 Elisa Kit
  • dapaf-1L Elisa Kit
  • dapaf-1S Elisa Kit
  • dApaf1 Elisa Kit
  • dark Elisa Kit
  • Dark/Apaf-I Elisa Kit
  • dark/dapaf-1/hac-1 Elisa Kit
  • Dark/Dapaf-1/HAC1 Elisa Kit
  • dark/hac-1/dapaf-1 Elisa Kit
  • Dark/Hac-1/dApaf1 Elisa Kit
  • Dmel\\CG6829 Elisa Kit
  • fog Elisa Kit
  • hac-1 Elisa Kit
  • Hac-1/Dark Elisa Kit
  • hac1 Elisa Kit
  • l(2)SH0173 Elisa Kit
  • mKIAA0413 Elisa Kit
  • T1 Elisa Kit
  • zgc:136543 Elisa Kit

Protein level used designations for APAF1

Apaf-1 related , Apaf-1 related killer , Apaf-1-related killer , Ark-PA , Ark-PB , CG6829-PA , CG6829-PB , apaf1-related killer , dark , drosophila Apaf-1-related killer , lethal (2) SH0173 , transcription unit 1 , apoptotic peptidase activating factor 1 , apoptotic protease-activating factor 1-like , apoptotic protease-activating factor 1 , apoptotic protease activating factor 1 , forebrain overgrowth , apaf-1

GENE ID SPECIES
36914 Drosophila melanogaster
444261 Xenopus laevis
100127738 Xenopus (Silurana) tropicalis
452153 Pan troglodytes
694164 Macaca mulatta
768257 Felis catus
100013051 Monodelphis domestica
100459074 Pongo abelii
100464163 Ailuropoda melanoleuca
100549497 Meleagris gallopavo
100556318 Anolis carolinensis
100590369 Nomascus leucogenys
317 Homo sapiens
11783 Mus musculus
78963 Rattus norvegicus
537782 Bos taurus
482620 Canis lupus familiaris
417926 Gallus gallus
100719903 Cavia porcellus
100513283 Sus scrofa
100052552 Equus caballus
100135699 Ovis aries
58131 Danio rerio
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