anti-APAF1 (APAF1) 抗体产品概述

Full name:
anti-Apoptotic Peptidase Activating Factor 1 抗体 (APAF1)
在www.antibodies-online.cn可供206 Apoptotic Peptidase Activating Factor 1 (APAF1) 抗体的29不同的供货商。 再加上,我们可以发APAF1 试剂盒 (47)APAF1 蛋白 (7)和数多这个蛋白质的别的产品。 总共268 APAF1产品已列进来了。
别名:
6230400I06Rik, anon-53Fa, APAF-1, apaf1, Apaf1l, arc, ark, CED4, CG6829, D-Apaf-1, dapaf, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, hac-1, Hac-1/Dark, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543

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引用最多的anti-APAF1 抗体

  1. Human Polyclonal APAF1 Primary Antibody for WB - ABIN967648 : Cecconi, Alvarez-Bolado, Meyer, Roth, Gruss: Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. in Cell 1998 (PubMed)
    Show all 6 references for 967648

  2. Human Monoclonal APAF1 Primary Antibody for IF, WB - ABIN968496 : Cain, Brown, Langlais, Cohen: Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 968496

  3. Human Monoclonal APAF1 Primary Antibody for EIA, IHC (fro) - ABIN400811 : Zou, Henzel, Liu, Lutschg, Wang: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. in Cell 1997 (PubMed)
    Show all 4 references for 400811

  4. Cow (Bovine) Polyclonal APAF1 Primary Antibody for WB - ABIN222876 : Dirks, Leeuwenburgh: Apoptosis in skeletal muscle with aging. in American journal of physiology. Regulatory, integrative and comparative physiology 2002 (PubMed)
    Show all 4 references for 222876

  5. Human Polyclonal APAF1 Primary Antibody for IHC (p), WB - ABIN2477457 : Hu, Benedict, Wu, Inohara, Núñez: Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 3 references for 2477457

  6. Gerbil Polyclonal APAF1 Primary Antibody for ICC, IHC (fro) - ABIN252079 : Kim, Lee, Park, Chung, Im, Noh, Han, Moon, Jung, Ryu: Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. in Virchows Archiv : an international journal of pathology 2015 (PubMed)

  7. Human Polyclonal APAF1 Primary Antibody for ICC, IF - ABIN4280962 : Rodić, Steranka, Makohon-Moore, Moyer, Shen, Sharma, Kohutek, Huang, Ahn, Mita, Taylor, Barker, Hruban, Iacobuzio-Donahue, Boeke, Burns: Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma. in Nature medicine 2015 (PubMed)

更多抗APAF1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis

  2. structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]

  3. ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.

  4. Daxx (显示 DAXX 抗体)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level

Human Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Loss of APAF-1 expression is associated with early recurrence in stage I-III colorectal cancer, suggesting that APAF-1 may have clinical value as a predictive marker of early recurrence.

  2. the markers Ets-1 (显示 ETS1 抗体) and APAF-1 relative to p53 (显示 TP53 抗体), Ki-67 (显示 MKI67 抗体) and PTEN (显示 PTEN 抗体) expression in colon adenomas/polyps, were investigated.

  3. Different selenium concentrations had varying effects on BAK1 (显示 BAK1 抗体) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD

  4. miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (显示 TBX1 抗体)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.

  5. HDAC (显示 HDAC3 抗体) inhibitors can induce p53 (显示 TP53 抗体) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.

  6. Renal APAF1 expression is increased in diabetes and diabetic nephropathy.

  7. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  8. These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.

  9. The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.

  10. cytochrome c (显示 CYCS 抗体) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly

Mouse (Murine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. miR (显示 MLXIP 抗体)-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR (显示 MLXIP 抗体)-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing.

  2. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death

  3. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  4. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.

  5. study demonstrates that MMP-3 (显示 MMP3 抗体) leads to caspase-9 (显示 CASP9 抗体) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

  6. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

  7. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (显示 HSP70 抗体)

  8. miR (显示 MLXIP 抗体)-23a/b and miR (显示 MLXIP 抗体)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.

  9. a role for Apaf1 at the mitochondria

  10. The Apaf-1-independent caspase (显示 CASP3 抗体) activation was not inhibited by Bcl-2 (显示 BCL2 抗体), and occurred without the release of cytochrome c (显示 CYCS 抗体) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.

Pig (Porcine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (显示 BIRC2 抗体).

Zebrafish Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

APAF1 抗原简介

Antigen Summary

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with APAF1

  • Apaf-1-related-killer (Ark) 抗体
  • apoptotic peptidase activating factor 1 (apaf1) 抗体
  • apoptotic peptidase activating factor 1 (APAF1) 抗体
  • apoptotic peptidase activating factor 1 (Apaf1) 抗体
  • apoptotic protease activating factor 1 (apaf1) 抗体
  • 6230400I06Rik 抗体
  • anon-53Fa 抗体
  • APAF-1 抗体
  • apaf1 抗体
  • Apaf1l 抗体
  • arc 抗体
  • ark 抗体
  • CED4 抗体
  • CG6829 抗体
  • D-Apaf-1 抗体
  • dapaf 抗体
  • dapaf-1 抗体
  • dApaf-1/DARK/HAC-1 抗体
  • Dapaf-1/HAC-1 抗体
  • dapaf-1L 抗体
  • dapaf-1S 抗体
  • dApaf1 抗体
  • dark 抗体
  • Dark/Apaf-I 抗体
  • dark/dapaf-1/hac-1 抗体
  • Dark/Dapaf-1/HAC1 抗体
  • dark/hac-1/dapaf-1 抗体
  • Dark/Hac-1/dApaf1 抗体
  • Dmel\\CG6829 抗体
  • fog 抗体
  • hac-1 抗体
  • Hac-1/Dark 抗体
  • hac1 抗体
  • l(2)SH0173 抗体
  • mKIAA0413 抗体
  • T1 抗体
  • zgc:136543 抗体

Protein level used designations for APAF1

Apaf-1 related , Apaf-1 related killer , Apaf-1-related killer , Ark-PA , Ark-PB , CG6829-PA , CG6829-PB , apaf1-related killer , dark , drosophila Apaf-1-related killer , lethal (2) SH0173 , transcription unit 1 , apoptotic peptidase activating factor 1 , apoptotic protease-activating factor 1-like , apoptotic protease-activating factor 1 , apoptotic protease activating factor 1 , forebrain overgrowth , apaf-1

GENE ID SPECIES
36914 Drosophila melanogaster
444261 Xenopus laevis
100127738 Xenopus (Silurana) tropicalis
452153 Pan troglodytes
694164 Macaca mulatta
768257 Felis catus
100013051 Monodelphis domestica
100459074 Pongo abelii
100464163 Ailuropoda melanoleuca
100549497 Meleagris gallopavo
100556318 Anolis carolinensis
100590369 Nomascus leucogenys
317 Homo sapiens
11783 Mus musculus
78963 Rattus norvegicus
537782 Bos taurus
482620 Canis lupus familiaris
417926 Gallus gallus
100719903 Cavia porcellus
100513283 Sus scrofa
100052552 Equus caballus
100135699 Ovis aries
58131 Danio rerio
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