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Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut (显示 GUSB 蛋白) inflammation.
Vdr (显示 CYP27B1 蛋白) and Casr (显示 CASR 蛋白) are required for beta-catenin (显示 CTNNB1 蛋白)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Absence of VDR (显示 CYP27B1 蛋白)-mediated PPARgamma (显示 PPARG 蛋白) suppression underlies alopecia in VDR (显示 CYP27B1 蛋白)-/- mice.
Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.
VDR (显示 CYP27B1 蛋白) is important for the maintenance of physiological level of Axin1 (显示 AXIN1 蛋白)
The data support the hypothesis that Vdr (显示 CYP27B1 蛋白) in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.
The data demonstrate that deficiency in the vitamin D signaling via VDR (显示 CYP27B1 蛋白) knockout enhances the pathological phenotype in this experimental cardiomyopathy and suggest an important role for vitamin D in modulating disease severity in common cardiovascular disorders.
Absence of VDR (显示 CYP27B1 蛋白) or presence of an unliganded VDR (显示 CYP27B1 蛋白) does not affect the profile and function of ex vivo generated bone marrow-derived dendritic cells.
JNK1 (显示 MAPK8 蛋白) physically and functionally interacted with VDR (显示 CYP27B1 蛋白) and positively regulated VDR (显示 CYP27B1 蛋白) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.
Vitamin D receptor activation reduces dissecting abdominal aortic aneurysm formation induced by Ang-II (显示 AGT 蛋白) in apoE (显示 APOE 蛋白)(-/-) mice
binds vitamin D3\; acts as a transcriptional regulator of the osteocalcin gene
vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D3 receptor
, vitamin D receptor
, vitamin D receptor alpha
, vitamin D receptor beta
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1