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UIMC1 蛋白

(Ubiquitin Interaction Motif Containing 1 (UIMC1))
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).
UIMC1 Protein (AA 1-385) (GST tag) UIMC1 Protein (AA 1-385) (GST tag) UIMC1 Protein (AA 1-385) (GST tag) (ABIN1324614)

UIMC1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

UIMC1 Protein (AA 1-719) (His tag) UIMC1 Protein (AA 1-719) (His tag) UIMC1 Protein (AA 1-719) (His tag) (ABIN3096257)

Crystallography grade UIMC1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS

UIMC1 Protein (AA 1-726) (His tag) (ABIN1634738)

UIMC1 宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % ELISA

UIMC1 蛋白 by Grade

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UIMC1 蛋白 by Origin

Find UIMC1 蛋白 for a variety of species such as anti-Human UIMC1, anti-Rat UIMC1. The species listed below are among those available. Click on a link to go to the corresponding products.

UIMC1 蛋白 by Source

Here you will find UIMC1 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

UIMC1 蛋白 by 蛋白类型

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UIMC1 蛋白 by 应用范围

Find UIMC1 蛋白 validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular UIMC1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324614
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096257
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1634738
Quantity 1 mg
Datasheet Datasheet

Aliases for UIMC1 蛋白

ubiquitin interaction motif containing 1 (UIMC1) 蛋白
ubiquitin interaction motif containing 1 (Uimc1) 蛋白
9430016E08Rik 蛋白
D330018D10Rik 蛋白
D630032M02Rik 蛋白
RAP80 蛋白
RGD1307009 蛋白
RIP110 蛋白
Rxrip110 蛋白
UIMC1 蛋白
X2HRIP110 蛋白
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