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Nicastrin 抗体

(Nicastrin (NCSTN))
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Nicastrin 抗体  (AA 16-115) Nicastrin 抗体  (AA 16-115) Nicastrin 抗体 (AA 16-115) (ABIN565059)

NCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

Nicastrin 抗体  (AA 429-669) Nicastrin 抗体  (AA 429-669) Nicastrin 抗体 (AA 429-669) (ABIN7268905)

NCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

Nicastrin 抗体  (AA 21-120) Nicastrin 抗体  (AA 21-120) Nicastrin 抗体 (AA 21-120) (ABIN761801)

NCSTN 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Nicastrin 抗体 by 适用

Find Nicastrin 抗体 for a variety of species such as anti-Human Nicastrin, anti-Mouse Nicastrin, anti-Rat Nicastrin. The species listed below are among those available. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 应用范围

Find Nicastrin 抗体 validated for a specific application such as WB, IF (cc), IF (p), ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 抗体来源

Find Nicastrin 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 抗原表位

Find Nicastrin 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 克隆形成能力

Find available monoclonal or polyclonal Nicastrin 抗体. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 克隆

Find Nicastrin 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

Nicastrin 抗体 by 标记

Find Nicastrin 抗体 with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular Nicastrin 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN565059
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN7268905
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (1)
  • (1)
Cat. No. ABIN761801
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB
Validations
  • (2)
Cat. No. ABIN6242494
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN525128
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN525129
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6263547
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN1859974
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN5014009
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (2)
Cat. No. ABIN3031996
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN500343
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN500345
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN761803
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN908279
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN908278
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our Nicastrin 抗体

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Nguyen, Hawkins, Bergeron, Supala, Huang, Westaway, St George-Hyslop, Rozmahel: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Weihofen, Martoglio: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Li, Fici, Mao, Myers, Shuang, Donoho, Pauley, Himes, Qin, Kola, Merchant, Nye: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).

Aliases for Nicastrin 抗体

nicastrin (NCSTN) 抗体
nicastrin (nct) 抗体
nicastrin (ncstn) 抗体
nicastrin (CpipJ_CPIJ001617) 抗体
nicastrin (Ncstn) 抗体
Nicastrin (aph-2) 抗体
9430068N19Rik 抗体
AA727311 抗体
agro 抗体
APH2 抗体
Aph2 抗体
CG7012 抗体
D1Dau13e 抗体
DKFZp469O2418 抗体
Dmel\\CG7012 抗体
dNct 抗体
Kiaa0253 抗体
mKIAA0253 抗体
NCSTN 抗体
Nct 抗体
Nic 抗体
nic 抗体
S5A 抗体
ST96B 抗体
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