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NEDD4 蛋白

(Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).

recommended

NEDD4 Protein (AA 791-900) (GST tag) (ABIN1312320)

NEDD4 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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recommended

NEDD4 Protein (AA 1-1319) (Strep Tag) (ABIN3094038)

Crystallography grade NEDD4 宿主: 人宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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recommended

NEDD4 Protein (AA 1-887) (Strep Tag) (ABIN3134115)

Crystallography grade NEDD4 宿主: 小鼠宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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NEDD4 蛋白 by Grade

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NEDD4 蛋白 by Origin

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NEDD4 蛋白 by Source

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NEDD4 蛋白 by 蛋白类型

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NEDD4 蛋白 by 应用范围

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Popular NEDD4 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

NEDD4 Protein (AA 791-900) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1312320

Quantity 10 μg

Datasheet Datasheet

NEDD4 Protein (AA 1-1319) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3094038

Quantity 1 mg

Datasheet Datasheet

NEDD4 Protein (AA 1-887) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134115

Quantity 1 mg

Datasheet Datasheet

NEDD4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2727061

Quantity 20 μg

Datasheet Datasheet

NEDD4 蛋白

Reactivity Mouse, Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN2750635

Quantity 5 applications

Datasheet Datasheet

Aliases for NEDD4 蛋白

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4) 蛋白
neural precursor cell expressed, developmentally down-regulated 4 (Nedd4) 蛋白
CG42279 gene product from transcript CG42279-RJ (Nedd4) 蛋白
E3 ubiquitin-protein ligase Nedd-4 (LOC411723) 蛋白
E3 ubiquitin-protein ligase NEDD4 (LOC100457150) 蛋白
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (nedd4) 蛋白
E3 ubiquitin-protein ligase NEDD4 (LOC100547485) 蛋白
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4) 蛋白
AA959633 蛋白
AL023035 蛋白
AU019897 蛋白
CG7555 蛋白
CG32184 蛋白
CG42279 蛋白
Dmel\\CG42279 蛋白
Dmel_CG7555 蛋白
Dmel_CG32184 蛋白
DNedd4 蛋白
dNedd4 蛋白
dNedd4-1 蛋白
E430025J12Rik 蛋白
GB16853 蛋白
mKIAA0093 蛋白
nedd4 蛋白
NEDD4 蛋白
Nedd4 蛋白
NEDD4-1 蛋白
Nedd4-1 蛋白
Nedd4a 蛋白
RPF1 蛋白

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Popular NEDD4 蛋白

Aliases for NEDD4 蛋白

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