Use your antibodies-online credentials, if available.
BCL6 (显示 BCL6 ELISA试剂盒) inhibits transcription by competing for the Notch1 (显示 NOTCH1 ELISA试剂盒) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (显示 NOTCH1 ELISA试剂盒)-independent manner
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs (显示 SMCP ELISA试剂盒))after their migration. Furthermore, the intracellular domain of Notch1 (显示 NOTCH1 ELISA试剂盒) (NICD1) was localized to nuclei of MCs (显示 SMCP ELISA试剂盒). These findings suggest that Notch (显示 NOTCH1 ELISA试剂盒) signaling at embryonic stages is involved in the dendritic complexity of MCs (显示 SMCP ELISA试剂盒)
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (显示 RUNX2 ELISA试剂盒) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (显示 CCL1 ELISA试剂盒) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (显示 NOTCH1 ELISA试剂盒) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Data demonstrate that Mesp2 (显示 Mesp2 ELISA试剂盒) potently represses Notch (显示 NOTCH1 ELISA试剂盒) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (显示 NOTCH1 ELISA试剂盒) inhibition
MAML1 acts as a coactivator for MEF2C (显示 MEF2C ELISA试剂盒) transcription and is essential for proper muscle development
Authors report that p300 (显示 EP300 ELISA试剂盒) and CBP (显示 CREBBP ELISA试剂盒) acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (显示 NOTCH1 ELISA试剂盒) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Notch (显示 NOTCH1 ELISA试剂盒) signaling was altered in almost half of the clear-cell renal cell carcinoma patients and copy number variances in MAML1 and KAT2B (显示 KAT2B ELISA试剂盒) were predominant changes.
The transcriptional coregulator MAML1 affects DNA methylation (显示 HELLS ELISA试剂盒) and gene expression patterns in human embryonic kidney cells.
study identifies that MAML1 is ubiquitinated in the absence of Notch (显示 NOTCH1 ELISA试剂盒) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (显示 TP53 ELISA试剂盒) associates with the Notch (显示 NOTCH1 ELISA试剂盒) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (显示 TP53 ELISA试剂盒)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (显示 EPCAM ELISA试剂盒), CK19 (显示 KRT19 ELISA试剂盒), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (显示 SNAI1 ELISA试剂盒) decreased transcription of Notch1 (显示 NOTCH1 ELISA试剂盒) intracellular domain (NICD (显示 NOTCH1 ELISA试剂盒)) target genes via competing with MAML1, co-activator, in NICD (显示 NOTCH1 ELISA试剂盒) complex.
Authors report that human papillomavirus type 8 E6 subverts NOTCH (显示 NOTCH1 ELISA试剂盒) activation during keratinocyte differentiation by inhibiting RBPJ (显示 RBPJ ELISA试剂盒)/MAML1 transcriptional activator complexes at NOTCH (显示 NOTCH1 ELISA试剂盒) target DNA.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog