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抗Mouse (Murine) ADAM17 抗体:
抗Human ADAM17 抗体:
抗Rat (Rattus) ADAM17 抗体:
Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900517
Zingoni, Cecere, Vulpis, Fionda, Molfetta, Soriani, Petrucci, Ricciardi, Fuerst, Amendola, Mytilineos, Cerboni, Paolini, Cippitelli, Santoni: Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. in Journal of immunology (Baltimore, Md. : 1950) 2015
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Human Monoclonal ADAM17 Primary Antibody for CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). in The Journal of biological chemistry 2012
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Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897862
Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005
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Human Polyclonal ADAM17 Primary Antibody for IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. in The Journal of biological chemistry 2005
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Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012
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Human Polyclonal ADAM17 Primary Antibody for ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997
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Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481
Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015
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Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN249487
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
Human Monoclonal ADAM17 Primary Antibody for IHC (p), PLA - ABIN563080
Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. in British journal of cancer 2009
Human Polyclonal ADAM17 Primary Antibody for FACS, IF (p) - ABIN705671
Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015
most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (显示 EGFR 抗体)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
In a clinically relevant CADASIL (显示 NOTCH3 抗体) mouse model, we show that exogenous ADAM17 or HB-EGF (显示 HBEGF 抗体) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (显示 KCNAB2 抗体) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (显示 TIMP3 抗体)-induced deficits.
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (显示 IL6 抗体) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (显示 TNF 抗体)-induced AP-2alpha (显示 TFAP2A 抗体) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (显示 RHBDF2 抗体) in the regulation of the ADAM17 and EGFR (显示 EGFR 抗体), and ADAM17 and TNFalpha (显示 TNF 抗体) signaling pathways, was examined.
Findings provide evidence that ADAM10 (显示 ADAM10 抗体), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (显示 NOTCH1 抗体) signaling.
this study shows that the iRhom2 (显示 RHBDF2 抗体)/ADAM17 pathway plays an important role in regulating CSF1R (显示 CSF1R 抗体) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (显示 TNF 抗体) and TNFR2 (显示 TNFRSF1B 抗体), thereby preventing overactivation of endogenous TNFR2 (显示 TNFRSF1B 抗体) signaling in cells of the vasculature.
the chaperone 78-kDa glucose-regulated protein (GRP78 (显示 HSPA5 抗体)) protects the MPD (显示 MVD 抗体) against PDI (显示 PADI1 抗体)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition.
The ADAM17 messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 (显示 ADAM10 抗体) mRNA and protein levels did not differ significantly between NPs (显示 NPS 抗体) and inferior turbinates (p > 0.05). ADAM10 (显示 ADAM10 抗体) and ADAM17 were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
The iRhom2 (显示 RHBDF2 抗体) N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF (显示 TNF 抗体) and EGFR (显示 EGFR 抗体) in inflammatory and innate immune responses. (Review)
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (显示 RPS6KA1 抗体)-dependent C/EBPbeta (显示 CEBPB 抗体) signaling pathway, which in turn initiates binding of C/EBPbeta (显示 CEBPB 抗体) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (显示 TNFSF11 抗体) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Aging and obesity cooperatively reduce caveolin-1 (显示 CAV1 抗体) expression and increase vascular endothelial ADAM17 activity and soluble TNF (显示 TNF 抗体) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
Our data demonstrated that elevated serum Semaphorin5A (Sema5A (显示 SEMA5A 抗体)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (显示 SEMA5A 抗体).
ADAM17 and ADAM10 (显示 ADAM10 抗体) cleave Nectin-4 (显示 PVRL4 抗体) and release soluble Nectin-4 (显示 PVRL4 抗体) (sN4).
ADAM17 was involved in porcine CD16 (显示 CD16 抗体) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (显示 CD163 抗体) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (显示 FYN 抗体)-induced c-Src (显示 SRC 抗体)-dependent manner mediates proteolytic activation of the EGF (显示 EGF 抗体)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (显示 TNF 抗体) stimulates Rac (显示 AKT1 抗体), ADAM17/TACE, and RhoA (显示 RHOA 抗体) through the guanine nucleotide exchange factor (显示 ARHGEF12 抗体) (GEF)-H1 (显示 ARHGEF2 抗体).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (显示 EGF 抗体) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme