anti-ADAM17 (ADAM17) 抗体产品概述

Full name:
anti-ADAM Metallopeptidase Domain 17 抗体 (ADAM17)
在www.antibodies-online.cn可供272 ADAM Metallopeptidase Domain 17 (ADAM17) 抗体的33不同的供货商。 再加上,我们可以发ADAM17 试剂盒 (34)ADAM17 蛋白 (17)和数多这个蛋白质的别的产品。 总共332 ADAM17产品已列进来了。
别名:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace

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引用最多的anti-ADAM17 抗体

  1. Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897862 : Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005 (PubMed)
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  2. Human Monoclonal ADAM17 Primary Antibody for FACS - ABIN4897863 : Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012 (PubMed)
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  3. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1531481 : Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015 (PubMed)
    Show all 3 references for 1531481

  4. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN1536098 : Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997 (PubMed)
    Show all 2 references for 1536098

  5. Human Polyclonal ADAM17 Primary Antibody for FACS, WB - ABIN388309 : Tellier, Canault, Poggi, Bonardo, Nicolay, Alessi, Nalbone, Peiretti: HDLs activate ADAM17-dependent shedding. in Journal of cellular physiology 2007 (PubMed)
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  6. Human Polyclonal ADAM17 Primary Antibody for EIA, WB - ABIN357025 : Takamune, Ikebe, Nagano, Shinohara: Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. in Biochemical and biophysical research communications 2007 (PubMed)
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  7. Human Polyclonal ADAM17 Primary Antibody for ELISA, WB - ABIN184721 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)

  8. Human Polyclonal ADAM17 Primary Antibody for FACS, IF (p) - ABIN705671 : Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015 (PubMed)

更多抗ADAM17的相互作用对抗体

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.

  2. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (显示 IL6 抗体) signals during inflammatory processes.

  3. These results show that TACE is a target of, and is downregulated by, soluble TNF (显示 TNF 抗体)-induced AP-2alpha (显示 TFAP2A 抗体) transcription factor in dendritic cells

  4. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (显示 RHBDF2 抗体) in the regulation of the ADAM17 and EGFR (显示 EGFR 抗体), and ADAM17 and TNFalpha (显示 TNF 抗体) signaling pathways, was examined.

  5. Findings provide evidence that ADAM10 (显示 ADAM10 抗体), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (显示 NOTCH1 抗体) signaling.

  6. this study shows that the iRhom2 (显示 RHBDF2 抗体)/ADAM17 pathway plays an important role in regulating CSF1R (显示 CSF1R 抗体) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation

  7. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (显示 TNF 抗体) and TNFR2 (显示 TNFRSF1B 抗体), thereby preventing overactivation of endogenous TNFR2 (显示 TNFRSF1B 抗体) signaling in cells of the vasculature.

  8. Aging and obesity cooperatively reduce caveolin-1 (显示 CAV1 抗体) expression and increase vascular endothelial ADAM17 activity and soluble TNF (显示 TNF 抗体) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  9. Thus, Leda-1/Pianp (显示 C12orf53 抗体) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (显示 ADAM10 抗体)/17 and intramembrane protease gamma-secretase.

  10. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (显示 AXL 抗体)kinase (Axl) in lupus-prone leukocytes.

Human ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (显示 TNFSF11 抗体) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  2. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  3. Aging and obesity cooperatively reduce caveolin-1 (显示 CAV1 抗体) expression and increase vascular endothelial ADAM17 activity and soluble TNF (显示 TNF 抗体) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  4. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (显示 SEMA5A 抗体)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (显示 SEMA5A 抗体).

  5. ADAM17 and ADAM10 (显示 ADAM10 抗体) cleave Nectin-4 (显示 PVRL4 抗体) and release soluble Nectin-4 (显示 PVRL4 抗体) (sN4).

  6. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (显示 TGFB1 抗体)/Smad (显示 SMAD1 抗体) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  7. FHL2 (显示 FHL2 抗体) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (显示 FHL2 抗体) complex in the development of colorectal cancer.

  8. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (显示 EGFR 抗体)-PI3K (显示 PIK3CA 抗体)-AKT (显示 AKT1 抗体) signaling pathway

  9. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (显示 AXL 抗体)) is rescued by combined matrix metalloproteases ADAM10 (显示 ADAM10 抗体) and TACE (ADAM17) inhibition.

  10. the TLR4 (显示 TLR4 抗体)/Gal-1 (显示 LGALS1 抗体) signaling pathway regulates lactate-mediated EMT (显示 ITK 抗体) processes through the activation of ADAM10 (显示 ADAM10 抗体) and ADAM17 in colon cancer cells.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) interaction partners

  1. ADAM17 was involved in porcine CD16 (显示 CD16 抗体) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (显示 CD163 抗体) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (显示 FYN 抗体)-induced c-Src (显示 SRC 抗体)-dependent manner mediates proteolytic activation of the EGF (显示 EGF 抗体)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (显示 TNF 抗体) stimulates Rac (显示 AKT1 抗体), ADAM17/TACE, and RhoA (显示 RHOA 抗体) through the guanine nucleotide exchange factor (显示 ARHGEF12 抗体) (GEF)-H1 (显示 ARHGEF2 抗体).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (显示 EGF 抗体) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 抗原简介

Antigen Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17) 抗体
  • a disintegrin and metallopeptidase domain 17b (adam17b) 抗体
  • ADAM metallopeptidase domain 17 (adam17) 抗体
  • a disintegrin and metallopeptidase domain 17 (Adam17) 抗体
  • ADAM metallopeptidase domain 17 (Adam17) 抗体
  • adam17 抗体
  • ADAM18 抗体
  • CD156B 抗体
  • CSVP 抗体
  • NISBD 抗体
  • si:dkey-81b15.2 抗体
  • Tace 抗体

Protein level used designations for ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPECIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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